Yazar "Nursal, Ayşe Feyda" için listeleme
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Impact of glucocorticoid receptor gene Bcl-1 variant on temporomandibular disorders
Tümer, Mehmet Kemal; Yerliyurt, Kaan; Nursal, Ayşe Feyda; Karakuş, Nevin; Tekcan, Akın; Yiğit, Serbülent (Scientific Publishers of India, 2017)Objectives: Temporomandibular Disorders (TMD) constitute a heterogeneous group of disorders characterized by alterations in mandibular movement. The aim of this study was to investigate the association between the Bcl1 ... -
Impact of the Functional VNTR Variants of the Interleukin-1 Receptor Antagonist and Interleukin-4 Genes on Oral Squamous Cell Carcinoma
Introduction: It has been shown that the host immune response and chronic inflammation could play a role as important risk factors for cancer. Oral squamous cell carcinoma (OSCC) is a common cancer worldwide. In this study, ... -
Impact of UCP2 -866G/A Variant on Smoking Risk
Objective: Mitochondria are multifunctional and dynamic organelles found in cells. Nicotine is a natural alkaloid found in the tobacco plant and has been well studied as a component of cigarette smoke. It has also been ... -
Importance of anaplastic lymphoma kinase gene re-arrangements on non-small cell lung cancer
Nursal, Ayşe Feyda (Kafkas Üniversitesi Tıp Fakültesi, 2017)Despite all improvements in treatment modalities, lung cancer is the leading cause of death related to cancers worldwide. Environmental, occupational and genetic factors, as well as smoking play role in the etiology. ... -
Interleukin-1 gene variants and the risk of non-syndromic microtia
Nursal, Ayşe Feyda; Bekerecioğlu, Mehmet; Büyükgüral, Berker; Pehlivan, Sacide (Pamukkale Üniversitesi, 2018)Purpose: Microtia is a congenital anomaly, manifested by a small and disfigured auricle. Interleukin (IL) 1 is an important mediator of inflammation and cartilage destruction, This study is aimed at investigating association ... -
Investigation of the role of interleukin-1 receptor antagonist VNTR variant on the Behçet’s disease
Dursun, Gul; Nursal, Ayşe Feyda; Demir, Helin Deniz; Karakuş, Nevin; Demir, Osman; Yiğit, Serbülent (2018)Objective: Behçet’s disease (BD), a chronic multisystem inflammatory disorder, is mainly characterized by relapsing periods of a wide range of clinical symptoms. Several cytokine genes may play important roles in the ... -
Is Complement Factor H Tyr402His Variant a Potential Cause of Ankylosing Spondylitis?
Pehlivan, Sacide; Akaltun, Mazlum Serdar; Pehlivan, Mustafa; Gürsoy, Savaş; Nursal, Ayşe Feyda (2020)Aim: Ankylosing spondylitis (AS) is an autoimmune disease caused by chronic inflammatory response. Complement system is the major component of the innate immune defence. In this study, we investigated the potential association ... -
Is there any Association between the Functional Variants of the NOS3 Gene and Psoriasis?
Pehlivan, Sacide; İnalöz, Hüseyin Serhat; Nursal, Ayşe Feyda; Gülel, Aslıhan; Pehlivan, Mustafa (2018)Introduction: Psoriasis (Ps) is a chronic, immune-mediated inflammatory skin disorder with an incompletely understood etiology. The aim of this study was to investigate the relationship between the suspectibility to Ps and ... -
Küçük hücreli dışı akciğer kanserinde MET geninin güncel durumu
Nursal, Ayşe Feyda (Bozok Üniversitesi Tıp Fakültesi, 2016)Akciğer kanseri tüm dünyada kansere bağlı ölüm sebepleri içinde ilk sırada yer alır. Tedavi alanında tüm gelişmelere rağmen hala kötü prognoza sahiptir. Akciğer kanseri histolojik tipine göre küçük hücreli akciğer kanseri ... -
Macrophage migration inhibitory factor -173GC variant might increase the risk of behçet's disease
Nursal, Ayşe Feyda; Yiğit, Serbülent; Tural, Ercan; Kalkan, Göknur; Tümer, Mehmet Kemal; Tekcan, Akın (S. Karger AG, 2018)Objective: The aim of the present study was to investigate any possible association between the macrophage migration inhibitory factor (MIF) -173GC variant and Behçet's disease (BD) in a group of Turkish patients. Subjects ... -
The MIF rs755622 Variant may Increase Susceptibility of Breast Cancer but not Gastrointestinal Cancer in a Turkish Population
Pehlivan, Sacide; Işıksaçan, Nilgün; Pehlivan, Mustafa; Günaldı, Meral; Oyacı, Yasemin; Nursal, Ayşe Feyda (2020)OBJECTIVE An increasing number of epidemiological and molecular evidence proposes that inflammation is a significant factor in the etiology of cancers. Macrophage Migration Inhibitory Factor (MIF) encodes a lymphokine ... -
THE miR-196a2T/C VARIANT AS A POSSIBLE PREDISPOSING FACTOR FOR ANKYLOSING SPONDYLITIS IN A TURKISH POPULATION
Pehlivan, Sacide; Gürsoy, Savaş; Nursal, Ayşe Feyda; Akaltun, Mazlum Serdar; Özdilli, Kürşat; Pehlivan, Mustafa (2020)Objective: Ankylosing spondylitis (AS) is a chronic inflammatory disorder. MicroRNAs (miRNAs) can function as either oncogenes or tumor suppressor genes. Altered miRNA expression has been implicated in the pathogenesis of ... -
Possible association between DNA repair gene variants and cannabis dependence in a Turkish cohort: a pilot study
Pehlivan, Sacide; Yazıcı, Ahmet Bülent; Aydın, Nazan; Nursal, Ayşe Feyda; Kurnaz, Selin; Öngel Atar, Ayça; Sever, Ülgen; Kıncır, Zeliha; Pehlivan, Mustafa; Çetinay Aydın, Pınar (Taylor and Francis Ltd., 2018)OBJECTIVE: Substance use disorder (SUD) has important effects on health and well-being. It is well known that genetic factors play a role in SUD. The purpose of this research was to investigate whether functional variants ... -
The possible role of CCR5Δ32 mutation in Crimean-Congo hemorrhagic fever infection
Rüstemoğlu, Aydın; Ekinci, Duygu; Nursal, Ayşe Feyda; Barut, Şener; Duygu, Fazilet; Günal, Özgür (John Wiley and Sons Inc., 2017)Crimean-Congo hemorrhagic fever infection (CCHF) is a viral zoonosis. The pathogenesis of this disease has not been established so far, however, cytokines account for its progression and outcome. The aim of the present ... -
The Role of Interleukin-4 VNTR Polymorphism in Dysmenorrhea Development
Aim: Primary dysmenorrhea (PD) is among the most common gynecological diseases in young women presenting to emergency department. It has been shown that cytokines played roles in PD pathogenesis. Interleukin-4 (IL-4), a ... -
The roles of endothelial nitric oxide synthase (eNOS) and myeloperoxidase (MPO) genes in microtia
Büyükgüral, Berker; Pehlivan, Sacide; Nursal, Ayşe Feyda; Bekerecioğlu, Mehmet (Deomed Publishing, 2016)Objective:The aim of this study was to determine the relationshipbetween polymorphisms of endothelial nitric oxide synthase (eNOS)and myeloperoxidase (MPO) genes and development of microtia. Methods:Nineteen (11 males, 8 ... -
Significance of IL-1Ra and IL-6 gene variants in Turkish patients with Crimean-Congo hemorrhagic fever
Say Coşkun, Umut Safiye; Nursal, Ayşe Feyda; Güneş, Ferda; Rüstemoğlu, Aydın; Yaylı, Abdullah; Karakuş, Nevin; Barut, Hüseyin Şener; Yiğit, Serbülent (Wolters Kluwer Medknow Publications, 2019)Objective: To investigate the association between IL-1Ra variable number of tandem repeat (rs2234663), IL-6 -597GA (rs1800797), IL-6 -572GC (rs1800796) and the risk of Crimean-Congo hemorrhagic fever (CCHF) in the Turkish ... -
Techniques for nucleic acid engineering: The foundation of gene manipulation
Tüzmen, Şükrü; Baskın, Yasemin; Nursal, Ayşe Feyda; Eraslan, Serpil; Esemen, Yağmur; Çalıbaşı, Gizem; Demir, Ayşe Banu; Abbasoğlu, Duygu; Hizel, Candan (Elsevier Inc., 2017)The journey of nucleic acid isolation and characterization has been a long one starting in the late 1800s. DNA isolation has led the way due to its stable chemical characteristic. Since its initial implementation the demand ... -
XRCC4 rs6869366 polymorphism is associated with susceptibility to both nicotine dependence and/or schizophrenia
Pehlivan, Sacide; Uysal, Metin Atilla; Aydın, Nazan; Nursal, Ayşe Feyda; Pehlivan, Mustafa; Yavuzlar, Hazal; Sever, Ülgen; Kurnaz, Selin; Yavuz, Fatih Kasım; Uysal, Suna; Çetinay Aydın, Pınar (Universidade de Sao Paulo, 2018)Background: Oxidative stress induced DNA damage has been assumed to contribute to the etiopathogenesis of schizophrenia (Sch). Smoking prevalence was more common in patients with Sch. The X-ray repair cross-complementation ...