Yazar "Özkan, Sibel Ayşıl" için listeleme
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Analytical and preparative scale separation of enantiomers of chiral drugs by chromatography and related methods
Gümüştaş, Mehmet; Özkan, Sibel Ayşıl; Chankvetadze, Bezhan (Bentham Science Publishers B.V., 2018)While the amino acids, enzymes and hormones are chiral, chirality plays significant role in the life of plants, animals, as well as the human being. Chirality of molecules is important in various industries, such as ... -
Analytical application of polymethylene blue-multiwalled carbon nanotubes modified glassy carbon electrode on anticancer drug irinotecan and determination of its ionization constant value
Karadaş Bakırhan, Nurgül; Şanlı, Senem; Akmeşe, Bediha; Doğan Topal, Burcu; Can, Alp; Özkan, Sibel Ayşıl (Elsevier B.V., 2013)The voltammetric behavior of anticancer drug irinotecan (IRT) was investigated at poly (methylene blue)/multi-walled carbon nanotube (PMB/MWCNT) modified glassy carbon electrode (GCE). The modified electrode surface was ... -
Carbon quantum dots co-catalyzed with multiwalled carbon nanotubes and silver nanoparticles modified nanosensor for the electrochemical assay of anti-HIV drug Rilpivirine
Aftab, Saima; Kurbanoğlu, Sevinç; Özçelikay, Göksu; Karadaş Bakırhan, Nurgül; Shah, Afzal; Özkan, Sibel Ayşıl (Elsevier B.V., 2019)In this study, a novel and sensitive voltammetric nanosensor has been developed for the first time, for the detection of Rilpivirine based on amine-functionalized multiwalled carbon nanotubes (NH 2 -fMWCNT) with Ag ... -
Degradation studies and thermodynamic parameters in aqueous solution of chemotherapeutic agents: Daunorubicin, doxorubicin and vincristine
Bakırhan, Nurgül Karadaş; Akmeşe, Bediha; Göver, Tuğçe; Imanzadeh, Hamideh; Özkan, Sibel Ayşıl (2019)The degradation of daunorubicin (DNR), doxorubicin (DXR) and vincristine (VCR) as chemotherapeutic agents was investigated under stress conditions such as acidic and alkaline media, oxidation, photolytic and heating. The ... -
Determination of pK a values of cefdinir and cefixime by LC and spectrophotometric methods and their analysis in pharmaceutical dosage forms
Şanlı, Nurullah; Şanlı, Senem; Sızır, Ümit; Gümüştaş, Mehmet; Özkan, Sibel Ayşıl (Friedr. Vieweg und Sohn Verlags GmbH, 2011)The pK a values of cefdinir and cefixime, which are used in the treatment of bacterial infections, have been determined precisely in water and methanol-water binary mixtures (20% v/v) using spectrophotometric titration and ... -
Determination of pKa values of some antihypertensive drugs by liquid chromatography and simultaneous assay of lercanidipine and enalapril in their binary mixtures
Gümüştaş, Mehmet; Şanlı, Senem; Şanlı, Nurullah; Özkan, Sibel Ayşıl (Elsevier B.V., 2010)In this study, pKa values were determined using the dependence of the retention factor on the pH of the mobile phase for three ionizable substances, namely, enalapril, lercanidipine and ramipril (IS). The effect of the ... -
Determination of pKa values of some butyrophenones, their sensitive LC-UV analysis in pharmaceutical dosage forms and stress degradation behavior under ICH-recommended stress conditions
Şanlı, Senem; Özkan, Sibel Ayşıl; Güney, Zeynep (2013)In this study, pKa values of some ionizable butyrophenones, namely, benperidol, droperidol, and haloperidol were determined using by the dependence of the retention factor on pH of the mobile phase. The effect of the mobile ... -
Development and validation of a liquid chromatographic method for concurrent assay of weakly basic drug verapamil and amphoteric drug trandolapril in pharmaceutical formulations
The analysis of weakly basic drugs such as verapamil by reverse-phase liquid chromatography remains a problem, particularly when present in combination with other drugs such as amphoteric compounds like trandolapril. In ... -
Development and validation of a stability-indicating RP-LC method for the determination of anticancer drug epirubicin in pharmaceuticals
Kurbanoğlu, Sevinç; Bozal Palabıyık, Burçin; Gümüştaş, Mehmet; Şanlı, Senem; Uslu, Bengi; Özkan, Sibel Ayşıl (Taylor and Francis Inc., 2014)In the present paper, sensitive, rapid, and different analytical methodology was developed for the determination of anticancer drug epirubicin (EPR). The mixture of epirubicin and moxifloxacin as internal standard was ... -
Development of a HILIC method for the determination of 5-fluorouracil from nano drug delivery systems and rat skin extracts
Amasya, Gülin; Gümüştaş, Mehmet; Badıllı, Ulya; Özkan, Sibel Ayşıl; Tarımcı, Nilüfer (Elsevier B.V., 2018)This is the first report in literature using hydrophilic interaction liquid chromatography (HILIC) in combination with diode array detector (DAD) for stability indicating determination of 5-Fluorouracil (5-FU) from its ... -
Electroanalytical characteristics of antipsychotic drug ziprasidone and its determination in pharmaceuticals and serum samples on solid electrodes
Kul, Dilek; Gümüştaş, Mehmet; Uslu, Bengi; Özkan, Sibel Ayşıl (Elsevier B.V., 2010)Ziprasidone is a psychotropic agent used for the treatment of schizophrenia. Its oxidation was investigated electrochemically at boron-doped diamond and glassy carbon electrodes using cyclic, differential pulse, and square ... -
Electroanalytical characterization of levodropropizine and its voltammetric determination in pharmaceuticals
Levodropropizine is a cough suppressant and easily oxidizable at the carbon-base electrodes. The electrooxidative behavior and determination of levodropropizine on glassy carbon and boron-doped diamond electrodes were ... -
Electrochemical approach for the sensitive determination of anticancer drug epirubicin in pharmaceuticals in the presence of anionic surfactant
Bozal Palabıyık, Burçin; Kurbanoğlu, Sevinç; Gümüştaş, Mehmet; Uslu, Bengi; Özkan, Sibel Ayşıl (Editions de l'Academie Republique Populaire, 2013)In this research, sensitive, rapid, different electrochemical methods were developed for the determination of anticancer drug epirubicin. The aim of the study was to fully validated determination of epirubicin in ... -
Electrochemical Approach on Mechanism of an Oral Progestin in Aqueous Media and its Fully Validated Detection via a Carbon-Metal Based Composite Sensor
Karadaş Bakırhan, Nurgül; Baymak Çelik, Melek Şirin; Çelik, Hayati; Uslu, Bengi; Özkan, Sibel Ayşıl (Wiley-VCH Verlag, 2018)Dienogest is a synthetic oral progestogen with unique pharmacological properties that is used orally in the treatment of endometrosis. The first time, the detailed electrochemical mechanism of dienogest is investigated in ... -
Electrochemical evaluation and determination of antiretroviral drug fosamprenavir using boron-doped diamond and glassy carbon electrodes
Gümüştaş, Mehmet; Özkan, Sibel Ayşıl (2010)Fosamprenavir is a pro-drug of the antiretroviral protease inhibitor amprenavir and is oxidizable at solid electrodes. The anodic oxidation behavior of fosamprenavir was investigated using cyclic and linear sweep voltammetry ... -
Electrochemical preparation of sodium dodecylsulfate doped over-oxidized polypyrrole/multi-walled carbon nanotube composite on glassy carbon electrode and its application on sensitive and selective determination of anticancer drug: Pemetrexed
Karadaş Bakırhan, Nurgül; Özkan, Sibel Ayşıl (Elsevier B.V., 2014)Electrochemical oxidation of pemetrexed (PMX) was studied on bare, carboxylic acid functionalized multi-walled carbon nanotubes and over-oxidized polypyrrole modified (oo-PPy/MWCNTs-COOH/GCE) glassy carbon electrodes by ... -
Erratum to: UPLC versus HPLC on drug analysis: advantageous, applications and their validation parameters
The authors would like to call the reader’s attention to the fact that unfortunately there were several references faultily assigned in Table 1. -
A Facile Strategy for Construction of Sensor for Detection of Ondansetron and Investigation of its Redox Behavior and Thermodynamic Parameters
Zaabal, Moufida; Doulache, Merzak; Karadaş Bakırhan, Nurgül; Kaddour, Samia; Saidat, Boubakeur; Özkan, Sibel Ayşıl (Wiley-VCH Verlag, 2019)A sodium dodecylsulfate-doped polypyrrole (SDS-PPy) film was elaborated on glassy carbon electrode (GCE) by an electrodeposition method in phosphate buffer solution (pH 2.0) containing pyrrole (Py) and sodium dodecyl sulfate ... -
Fully validated simultaneous determination of bisoprolol fumarate and hydrochlorothiazide in their dosage forms using different voltammetric, chromatographic, and spectrophotometric analytical methods
Bozal Palabıyık, Burçin; Gümüştaş, Mehmet; Doğan Topal, Burcu; Uslu, Bengi; Özkan, Sibel Ayşıl (2013)Voltammetric, chromatographic, and spectrophotometric methods were developed for the simultaneous determination of bisoprolol fumarate (BIS) and hydrochlorothiazide (HCZ). Differential pulse and square wave voltammetry ... -
Fulvestrant-loaded polymer-based nanoparticles for local drug delivery: Preparation and in vitro characterization
Hasçiçek, Canan; Şengel Türk, Ceyda Tuba; Gümüştaş, Mehmet; Özkan, Sibel Ayşıl; Bakar, Filiz; Daş Evcimen, Net; Savaşer, Ayhan; Özkan, Yalçın (Editions de Sante, 2017)The present investigation was aimed at optimizing Fulvestrant (FLV)-loaded nanoparticulate formulations to overcome side effects caused by the intramuscular injection of FLV, and to prolong local intratumoral action at ...
