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Determination of pKa values of some antipsychotic drugs by HPLC-correlations with the kamlet and taft solvatochromic parameters and HPLC analysis in dosage forms

Şanlı, Senem; Akmeşe, Bediha; Altun, Yüksel (2013)

In this study, ionization constant (pKa) values were determined by using the dependence of the retention factor on the pH of the mobile phase for four ionizable drugs, namely, risperidone (RI), clozapine (CL), olanzapine ...
Solvent effects on pKa values of some substituted sulfonamides in acetonitrile-water binary mixtures by the UV-spectroscopy method

Şanlı, Senem; Altun, Yüksel; Şanlı, Nurullah; Alsancak, Güleren; Beltran, Jose L. (2009)

The examination of the dissociation constants of sulfonamides is essential in drug-design studies and in explaining the biopharmaceutical properties of substances. The dissociation constants of ten common human and veterinary ...