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Effect of precipitation inhibitors on supersaturation and solubility of furosemide
Gulsun, Tugba; Ozturk, Naile; Kara, Asli; Sahin, Selma; Vural, Imran (Marmara Univ, 2021)Furosemide is a widely used diuretic drug for the treatment of edema associated with heart, liver cirrhosis, renal diseases and hypertension. It is a Class IV drug with low aqueous solubility and low permeability according ... -
Exploiting ionisable nature of PEtOx-co-PEI to prepare pH sensitive, doxorubicin-loaded micelles
Ozturk, Naile; Kara, Asli; Gulyuz, Sevgi; Ozkose, Umut Ugur; Tasdelen, Mehmet Atilla; Bozkir, Asuman; Vural, Imran (Taylor & Francis Ltd, 2020)Aims This study was conducted to evaluate block copolymers containing two different poly(ethyleneimine) (PEI) amounts, as new pH-sensitive micellar delivery systems for doxorubicin. Methods Micelles were prepared with block ...