Mühendislik Fakültesi
Mühendislik fakültesine ait koleksiyonlar bu alt bölümde listelenir.
https://hdl.handle.net/11491/13
2024-03-29T14:36:49Z
2024-03-29T14:36:49Z
Photocrosslinked methacrylated pectin and methacrylated hyaluronic acıd wound dressing loaded with oleuropein as bioactive agent
Moran Bozer, Büşra
Özkahraman, Bengi
Mert Balaban, Hümeyra
https://hdl.handle.net/11491/8775
2024-02-01T07:04:52Z
2023-01-01T00:00:00Z
Photocrosslinked methacrylated pectin and methacrylated hyaluronic acıd wound dressing loaded with oleuropein as bioactive agent
Moran Bozer, Büşra; Özkahraman, Bengi; Mert Balaban, Hümeyra
Oleuropein-loaded photocrosslinked hydrogels, consisting of methacrylated pectin (PEC-MA) andmethacrylated hyaluronic acid (HA-MA), were developed as a new hydrogel wound dressing.Pectin and hyaluronic acid were methacrylated and the composite hydrogels were developed byphotocrosslinking of the methacrylated polymer precursors. Methacrylation and the photocros-slinking reactions were approved by1H-NMR and FTIR analyses. In addition to thermal and mor-phological characterizations, swelling andin vitrodegradation studies were performed. Moreimportantly, bioactivity studies, such as cytotoxicity, genotoxicity and hemolysis were performedto reveal the potential of the oleuropein-loaded photocrosslinked hybrid hydrogels for wounddressing applications.In vitroscratch assay studies showed that oleuropein-loaded wound dressingeffectively promoted the wound healing compared to the control in 24 hrs. Oleuropein-loadedphotocrosslinked hydrogels had no genotoxic and cytotoxic effects on L929 cells and could havea potential for wound healing applications.
2023-01-01T00:00:00Z
Quantification of Phenolic Component by LC-HESI-MS/MS and Evaluation of Antioxidant Activities of Crocus Ancyrensis (Ankara cigdemi) Extracts Obtained with Different Solvents
Kayır, Ömer
Doğan, Hacer
Alver, Erol
Bilici, İbrahim
https://hdl.handle.net/11491/8771
2024-01-31T12:41:33Z
2023-01-01T00:00:00Z
Quantification of Phenolic Component by LC-HESI-MS/MS and Evaluation of Antioxidant Activities of Crocus Ancyrensis (Ankara cigdemi) Extracts Obtained with Different Solvents
Kayır, Ömer; Doğan, Hacer; Alver, Erol; Bilici, İbrahim
In this study, Crocus ancyrensis was extracted from different parts of the plants with various solvents and their antioxidant activities and phenolic contents were investigated in detail for the first time. The highest amount of total phenolic substance in all parts of the plant was determined in the stigmaless flower. In the DPPH and FRAP methods, the highest antioxidant activity was obtained from the water extraction from the plant. Rutin is the highest detected by LC MS/MS. Stigmaless flower extract in all solvents is attributed to the component that contributes the most to antioxidant capacity. p-hydroxy benzoic acid was detected as the highest phenolic component after rutin. When the antioxidant activity results were examined, it was determined that the highest activity was in the water extract. As a result, it is evaluated that rutin and p-hydroxybenzoic acid in the plant contribute to the antioxidant capacity.
2023-01-01T00:00:00Z
Chemical composition of essential oils from Crocus ancyrensis (Herbert) Maw Spreading In Çorum (Türkiye) Region
Doğan, Hacer
Kayır, Ömer
Alver, Erol
Bilici, İbrahim
https://hdl.handle.net/11491/8770
2024-02-01T12:14:58Z
2023-01-01T00:00:00Z
Chemical composition of essential oils from Crocus ancyrensis (Herbert) Maw Spreading In Çorum (Türkiye) Region
Doğan, Hacer; Kayır, Ömer; Alver, Erol; Bilici, İbrahim
Abstract: Crocus ancyrensis is a yellow-flowered Crocus species and is in the same family and genus with saffron. Although various studies have been conducted on the antioxidant capacity and essential oil content characterization of saffron (Crocus sativus), there is no literature information about the C. ancyrensis plant, which is known as Crocus among the people. The members of Crocus family contain many valuable components including antioxidants, phenolic compounds and essential oils. The essential oils obtained from this family is a complex mixture of more than 30 components, which are primarily terpenes and their derivatives. These mixtures are used in paint, medicine, and food applications especially in the cosmetics sector. In the study, the essential oils of the Crocus ancyrensis plant were extracted with the clevenger system and characterized by GC-MS analyses. As a result, 23 volatile components were identified. 2-Hexenal, 1-ethylbutyl Hydroperoxide, 2-nitro-Hexane, β-Isophorone, α-Isophorone, 2-Caren-10-al and Eugenol are found as the main components of Crocus ancyrensis plant extract. Due to the antioxidant, antimicrobial, antifungal, anticancer and odorant properties of some of the identified components, C. ancyrensis can be used as a medicinal aromatic plant in various fields, especially in the cosmetics and perfume industry.
2023-01-01T00:00:00Z
Mechanical and thermal properties of recycled polyethylene/surface treated hemp fiber bio-composites
Güney, Olcay
Bilici, İbrahim
Doğan, Deniz
Metin, Ayşegül Ülkü
https://hdl.handle.net/11491/8769
2024-01-31T11:49:23Z
2023-01-01T00:00:00Z
Mechanical and thermal properties of recycled polyethylene/surface treated hemp fiber bio-composites
Güney, Olcay; Bilici, İbrahim; Doğan, Deniz; Metin, Ayşegül Ülkü
Hemp is a good option for polyethylene additives because of its high cellulose and fibrous content. This study aims to modify natural hemp fibers with the maleic anhydride/ionic liquid method, manufacture the composites, and compare the thermal and mechanical properties of natural hemp fiber and hemp cellulose. In this study recycled polyethylene as a binder, and filling ratios between 0 and 50 (wt/wt)% are investigated as a parameter. Differential scanning calorimeter and thermomechanical analysis were performed, and it was determined that the coefficient of thermal expansion from 973 to 147 ppm/K. It was determined that the strength of composite materials obtained from cellulose fibers with maleic anhydride/liquid ionic modification improved by around 20% from 19.5 to 24.4 MPa. In addition, as a result of scanning electron microscope analyses performed on the fractured surfaces, it was determined that the pressure, temperature, and time were suitable for producing composite materials. This work shows the potential of recycled polyethylene/hemp composites as a sustainable green material with simple fabrication procedure and useful mechanical and thermal properties. © 2023 The Authors. Polymer Composites published by Wiley Periodicals LLC on behalf of Society of Plastics Engineers.
2023-01-01T00:00:00Z