Gelişmiş Arama

Basit öğe kaydını göster

dc.contributor.authorGümüştaş, Mehmet
dc.contributor.authorÖzkan, Sibel Ayşıl
dc.contributor.authorChankvetadze, Bezhan
dc.date.accessioned2019-05-13T08:58:10Z
dc.date.available2019-05-13T08:58:10Z
dc.date.issued2018
dc.identifier.citationGumustas, M., Ozkan, S. A., & Chankvetadze, B. (2018). Analytical and preparative scale separation of enantiomers of chiral drugs by chromatography and related methods. Current medicinal chemistry, 25(33), 4152-4188.en_US
dc.identifier.issn0929-8673
dc.identifier.urihttps://doi.org/10.2174/0929867325666180129094955
dc.identifier.urihttps://hdl.handle.net/11491/1084
dc.description.abstractWhile the amino acids, enzymes and hormones are chiral, chirality plays significant role in the life of plants, animals, as well as the human being. Chirality of molecules is important in various industries, such as pharmaceutical, agricultural, food, electronics, etc. Chiral drugs may have different bioavailability, distribution, biotransformation and excretion, as well as quantitatively and/or qualitatively different pharmacological or toxic properties. Enantiomerically pure chiral drugs have been increasingly developed for the pharmaceutical market due to their superiority from the viewpoints of potency and safety. This is supported by the development of new methods for enantioselective production of the chiral compounds, as well as by the capability of the enantioselective analytical methods to allow a detection and quantification of minor enantiomeric impurity in the presence of another enantiomer in a large excess. The aim of the present review is to provide a short summary of the basic principles of chiral separations on an analytical and preparative scale. In addition, some selected applications for analytical techniques, such as gas chromatography, supercritical fluid chromatography, high performance liquid chromatography, capillary electrophoresis and capillary electrochromatography for the separation of enantiomers of chiral pharmaceuticals published in the last two years are also discussed. © 2018 Bentham Science Publishers.en_US
dc.language.isoeng
dc.publisherBentham Science Publishers B.V.en_US
dc.relation.isversionof10.2174/0929867325666180129094955en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnalytical Scaleen_US
dc.subjectChiral Drugsen_US
dc.subjectChiralityen_US
dc.subjectEnantioseparationsen_US
dc.subjectPreparative Scaleen_US
dc.subjectSeparation of Enantiomersen_US
dc.titleAnalytical and preparative scale separation of enantiomers of chiral drugs by chromatography and related methodsen_US
dc.typereviewen_US
dc.relation.journalCurrent Medicinal Chemistryen_US
dc.departmentHitit Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümüen_US
dc.authorid0000-0003-2793-7154en_US
dc.authorid0000-0001-7494-3077en_US
dc.identifier.volume25en_US
dc.identifier.issue33en_US
dc.identifier.startpage4152en_US
dc.identifier.endpage4188en_US
dc.relation.publicationcategoryDiğeren_US


Bu öğenin dosyaları:

DosyalarBoyutBiçimGöster

Bu öğe ile ilişkili dosya yok.

Bu öğe aşağıdaki koleksiyon(lar)da görünmektedir.

Basit öğe kaydını göster