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dc.contributor.authorBilgi, Ahmet
dc.contributor.authorAbalı, Remzi
dc.contributor.authorTonbaklar Bilgi, Pınar
dc.contributor.authorŞahin, Mustafa
dc.contributor.authorTunçdemir, Matem
dc.contributor.authorBoran, Ahmet Birtan
dc.date.accessioned2019-05-13T08:58:13Z
dc.date.available2019-05-13T08:58:13Z
dc.date.issued2019
dc.identifier.citationBilgi, A., Abalı, R., Bilgi, P. T., Şahin, M., Tunçdemir, M. Boran, A. B. (2019). The apoptotic effects of bisphenol A exposure on the rat ovary: an experimental study. Environmental Science and Pollution Research, 26(10), 10198-10203.en_US
dc.identifier.issn0944-1344
dc.identifier.urihttps://doi.org/10.1007/s11356-019-04487-6
dc.identifier.urihttps://hdl.handle.net/11491/1095
dc.description.abstractBisphenol A (BPA) is a key endocrine-disrupting chemical (EDC) in the manufacturing industry. It is found in the structure of compounds such as polycarbonate and epoxy in combination with other chemicals. Our objective was to investigate the effect of BPA on rat ovaries. A total of 32 female rats were divided into four equal groups: In group 1 (control), vehicle was administered; in group 2, BPA 50 ?g/day was administered intraperitoneally; in group 3, BPA 100 mg/kg/day was administered intraperitoneally; and in group 4, BPA 100 mg/kg/day and vitamin C (50 mg/kg) were administered intraperitoneally, while vitamin E (50 mg/kg) was administered intramuscularly. Thirty days after the treatment, the effects of BPA on the ovaries were evaluated by terminal deoxynucleotidyltransferase [TdT]-mediated dUTP-biotin nick end labeling (TUNEL) assay. There was no difference in the number of apoptotic cells between group 2 and group 4. In addition, there was no significant difference between control group and group 2, 4. However, the number of apoptotic cells per unit area was significantly increased in group 3 compared with all groups (p < 0.01, p < 0.05). In conclusion, this study showed that high doses of BPA (100 mg/kg/day) have a toxic effect on the ovaries. The fact that the number of apoptotic cells in the group administered with high dose of BPA + 50 mg/kg/day vitamin C + 50 mg/kg/day vitamin E was lower than that of the high-dose BPA-administered group shows that these vitamins may have a protective effect. © 2019, Springer-Verlag GmbH Germany, part of Springer Nature.en_US
dc.language.isoeng
dc.publisherSpringer Verlagen_US
dc.relation.isversionof10.1007/s11356-019-04487-6en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApoptosisen_US
dc.subjectBisphenol Aen_US
dc.subjectOvaryen_US
dc.subjectTUNELen_US
dc.titleThe apoptotic effects of bisphenol A exposure on the rat ovary: an experimental studyen_US
dc.typearticleen_US
dc.relation.journalEnvironmental Science and Pollution Researchen_US
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.identifier.volume26en_US
dc.identifier.issue10en_US
dc.identifier.startpage10198en_US
dc.identifier.endpage10203en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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