Is there a role for kisspeptin in pathogenesis of polycystic ovary syndrome?

Abstract

Aim: To investigate association of kisspeptin levels in infertile women with different ovarian reserve patterns. Materials and methods: In this prospective cross-sectional study, 157 participants were recruited. The women were divided into three groups: (i) adequate ovarian reserve (AOR) (n = 57), (ii) high ovarian reserve (PCOS) (n = 60), (iii) diminished ovarian reserve (DOR) (n = 40). Weight, height, waist circumference (WC), hip circumference (HC), body mass index (BMI), waist/hip ratio (WHR) were measured. The blood samples were analyzed for estradiol (E2), follicle-stimulating hormone (FSH), luteinizing hormone (LH), total testosterone (TT), 17-hydroxy progesterone (17OHP), dehydroepiandrosterone sulfate (DHEAS), antimullerian hormone (AMH), kisspeptin measurements. Results: FSH concentration was higher and AMH concentration was lower in DOR group (p <.001, p <.001, respectively). The mean LH, TT and DHEAS levels were higher in PCOS group (p =.001, p <.00 and p =.003, respectively). The 17OHP level did not differ among the groups (p =.15). Women with PCOS possessed the highest kisspeptin level (p =.01). The kisspeptin level was negatively correlated with FSH level (r = ?0.18, p =.02) and positively correlated with TT and DHEAS levels (r = 0.17, p =.02 and r = 0.23, p =.003, respectively). Conclusions: Women with PCOS had increased serum kisspeptin levels. Kisspeptin concentrations were negatively correlated with serum FSH and positively correlated with serum TT and DHEAS levels. © 2017 Informa UK Limited, trading as Taylor & Francis Group.