Synthesis of {substituted-[(4-{[4-(carboxymethyl-carbamoyl)phenylimino] methyl}benzylidene)-amino]benzoylamino}carboxylic acids

Abstract

Some novel derivatives of methotrexate like compounds 2a-f have been synthesized, using terephthalaldehyde, isophthalaldehyde, 4-aminobenzoic acid and amino acids (glycine, ?-alanine, L-glutamic acid). The structures of the products were identified by spectroscopic methods and antimicrobial effects of these compounds have been investigated on bacterial and yeast cells.