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dc.contributor.authorYaman Tunç, Senem
dc.contributor.authorAğaçayak, Elif
dc.contributor.authorYaman Görük, Neval
dc.contributor.authorİçen, Mehmet Sait
dc.contributor.authorTurgut, Abdülkadir
dc.contributor.authorAlabalık, Ulaş
dc.contributor.authorToğrul, Cihan
dc.contributor.authorEkinci, Cenap
dc.contributor.authorEkinci, Aysun
dc.contributor.authorGül, Talip
dc.date.accessioned2019-05-13T09:02:38Z
dc.date.available2019-05-13T09:02:38Z
dc.date.issued2016
dc.identifier.citationYaman Tunç, S., Ağaçayak, E., Yaman Görük, N., İçen, M. S., Turgut, A., Alabalık, U., Toğrul, C., Ekinci, C., Ekinci, A., Gül, T. (2016). Protective effects of honokiol on ischemia/reperfusion injury of rat ovary: an experimental study. Drug Design, Development and Therapy, 10, 1077-1083.en_US
dc.identifier.issn1177-8881
dc.identifier.urihttps://doi.org/10.2147/DDDT.S93768
dc.identifier.urihttps://hdl.handle.net/11491/1293
dc.description.abstractAim: The purpose of this study was to investigate the protective effect of honokiol on experimental ischemia/reperfusion injury of rat ovary. Materials and methods: A total of 40 female Wistar albino rats were used in this study. The rats were divided into five groups as follows: sham (Group I), torsion (Group II), torsion + detorsion (Group III), torsion + detorsion + saline (Group IV), and torsion + detorsion + honokiol (Group V). Bilateral adnexa in all the rats except for those in the sham group were exposed to torsion for 3 hours. The rats in Group IV were administered saline, whereas the rats in Group V were administered honokiol by intraperitoneal route 30 minutes before detorsion. Tissue and plasma concentrations of malondialdehyde and nitric oxide were determined. Ovarian tissue was histologically evaluated. Data analyses were performed by means of Kruskal–Wallis test and Mann–Whitney U-test (Bonferroni correction) in SPSS 15.0 (Statistical Package for Social Sciences; SPSS Inc., Chicago, IL, USA). Results: The torsion and detorsion groups had higher scores in vascular congestion, hemorrhage, and inflammatory cell infiltration compared with the sham group (P<0.005). In addition, total histopathological scores were significantly higher in the torsion and detorsion groups compared with the sham group (P<0.005). A significant reduction was observed in hemorrhage, inflammatory cell infiltration, and cellular degeneration scores, of all histopathological scores, in the honokiol group (P<0.005). Ovarian tissue concentrations of malondialdehyde were significantly higher in the torsion and detorsion groups compared with the sham and honokiol groups (P<0.005). Ovarian tissue concentrations of nitric oxide, on the other hand, were significantly higher in the torsion group compared with the sham, saline, and honokiol groups (P<0.005). Conclusion: Honokiol has a beneficial effect on ovarian torsion-related ischemia/reperfusion injury. © 2016 Yaman Tunc et al.en_US
dc.language.isoeng
dc.publisherDove Medical Press Ltd.en_US
dc.relation.isversionof10.2147/DDDT.S93768en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution-NonCommercial 3.0 Unported (CC BY-NC 3.0)*
dc.rights.urihttps://creativecommons.org/licenses/by-nc/3.0/*
dc.subjectHonokiolen_US
dc.subjectIschemia/Reperfusion Injuryen_US
dc.subjectMalondialdehydeen_US
dc.subjectNitric Oxideen_US
dc.subjectOvaryen_US
dc.titleProtective effects of honokiol on ischemia/reperfusion injury of rat ovary: an experimental studyen_US
dc.typearticleen_US
dc.relation.journalDrug Design, Development and Therapyen_US
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.identifier.volume10en_US
dc.identifier.startpage1077en_US
dc.identifier.endpage1083en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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