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dc.contributor.authorAydın, Oktay
dc.contributor.authorAydınuraz, Kuzey
dc.contributor.authorAğalar, Fatih
dc.contributor.authorŞahiner, İbrahim Tayfun
dc.contributor.authorAğalar, Canan
dc.contributor.authorBayram, Cem
dc.contributor.authorDenkbaş, Emir Baki
dc.contributor.authorAtasoy, Pınar
dc.identifier.citationAydın, O., Aydınuraz, K., Ağalar, F., Şahiner, İ. T., Ağalar, C., Bayram, C., Denkbaş, E. B., Atasoy, P. (2017). The effect of thymoquinone coating on adhesive properties of polypropylene mesh. BMC surgery, 17(1).en_US
dc.description.abstractBackground: An incisional hernia is a common complication following abdominal surgery. Polypropylene mesh is frequently used in the repair of such defects and has nearly become the standard surgical treatment modality. Though they are very effective in reducing recurrence, mesh materials exhibit a strong stimulating effect for intraabdominal adhesion. The thymoquinone (TQ) extracted from Nigella sativa seeds has potential medical properties. TQ has anti-inflammatory, antioxidant and antibacterial properties. The aim of this study is to coat polypropylene mesh with TQ in order to investigate the effect of surface modification on intraabdominal adhesions. Methods: TQ-coated polypropylene mesh material was tested for cytotoxicity, contact angle, surface spectroscopy, TQ content, sterility, and electron microscopic surface properties. An experimental incisional hernia model was created in study groups, each consisting of 12 female Wistar rats. The defect was closed with uncoated mesh in control group, with polylactic acid (PLA) coated mesh and PLA-TQ coated mesh in study groups. Adhesion scores and histopathologic properties were evaluated after sacrifice on postoperative 21th day. Results: Granuloma formation, lymphocyte and polymorphonuclear leukocyte infiltration, histiocyte fibroblast and giant cell formation, capillary infiltration, collagen content were significantly reduced in the PLA-TQ coated mesh group (p < 0.05). Though not statistically significant, likely due to the limited number of study animals, adhesion formation was also reduced in the PLA-TQ coated mesh group (p: 0.067). Conclusion: TQ coated mesh is shown to reduce adhesion formation and TQ is a promising coating material for mesh surface modification. © 2017 The Author(s).en_US
dc.publisherBioMed Central Ltd.en_US
dc.subjectIncisional Herniaen_US
dc.subjectIntraabdominal Adhesionen_US
dc.subjectPolypropylene Meshen_US
dc.titleThe effect of thymoquinone coating on adhesive properties of polypropylene meshen_US
dc.relation.journalBMC Surgeryen_US
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US

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