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dc.contributor.authorKüçükler, Ferit Kerim
dc.contributor.authorGörkem, Ümit
dc.contributor.authorŞimşek, Yasin
dc.contributor.authorKocabaş, Ramazan
dc.contributor.authorGüler, Serdar
dc.date.accessioned2019-05-13T09:07:01Z
dc.date.available2019-05-13T09:07:01Z
dc.date.issued2018
dc.identifier.citationKüçükler, F. K., Görkem, Ü., Şimşek, Y., Kocabaş, R., Güler, S. (2018). Evaluation of ovarian reserve in women with overt or subclinical hypothyroidism. Archives of Medical Science: AMS, 14(3), 521-526.en_US
dc.identifier.issn1734-1922
dc.identifier.urihttps://doi.org/10.5114/aoms.2016.58621
dc.identifier.urihttps://hdl.handle.net/11491/1705
dc.description.abstractIntroduction: Thyroid dysfunction is among the most common autoimmune disorders in women of reproductive age. Previous studies have shown the association between autoimmune thyroid disease (AITD) and infertility. Anti-Müllerian hormone (AMH) is secreted by granulosa cells and is a useful marker for assessment of ovarian reserve. In the present study, we sought to evaluate the ovarian reserves of women with autoimmune thyroid disorder by measurement of AMH values. Material and methods: This prospective study included women with newly diagnosed AITD aged between 20 and 40 years. Patients were divided into three groups: Subclinical hypothyroidism (SCH, n = 21), overt hypothyroidism (OH, n = 21) and controls (CG, n = 32). Study parameters included serum free T4, free T3, thyroid-stimulating hormone, anti-thyroglobulin, anti-thyroid peroxidase antibodies, follicle-stimulating hormone, luteinizing hormone, estradiol and AMH concentrations measured in the early follicular phase. Antral follicle count (AFC) was assessed with ultrasound. Body mass index (BMI) and waist circumference of the patients were noted. Results: No significant difference was found among SCH, OH and CG in regard to ovarian reserves measured by AMH values (p = 0.19) and AFC (p = 0.80). A significant negative correlation was found between AMH and BMI (r = -0.382, p = 0.001). Anti-Müllerian hormone and waist circumference (r = -0.330, p = 0.004) were also negatively correlated. Conclusions: Although AMH values were not significantly different among groups, AMH values were lower in OH and SCH patients, indicating a possible need for close monitoring of these patients. © 2016 Termedia & Banach.en_US
dc.language.isoeng
dc.publisherTermedia Publishing House Ltd.en_US
dc.relation.isversionof10.5114/aoms.2016.58621en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnti-Müllerian Hormoneen_US
dc.subjectAutoimmune Thyroid Diseaseen_US
dc.subjectFertile Womenen_US
dc.titleEvaluation of ovarian reserve in women with overt or subclinical hypothyroidismen_US
dc.typearticleen_US
dc.relation.journalArchives of Medical Scienceen_US
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.identifier.volume14en_US
dc.identifier.issue3en_US
dc.identifier.startpage521en_US
dc.identifier.endpage526en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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