An avoidable adverse drug reaction: Nicolau syndrome
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CitationGülseren, D., Şahin, E. B., Bozdoğan, O., Artüz, F. (2017). An avoidable adverse drug reaction: Nicolau syndrome. International Wound Journal, 14(2), 440-441.
Dear Editors, Nicolau syndrome (NS), or embolia cutis medicamentosa, is a rare complication of intramuscular injection, leading to local ischemic necrosis involving the skin and adipose tissue 1. It was first described in 1924 after intramuscular injection of a bismuth‐in‐oil suspension for the treatment of syphilis. Subsequent case reports have documented this reaction to a variety of medications 2, 3. Here, we report a case of NS following an intramuscular injection of diclofenac sodium.