Gelişmiş Arama

Basit öğe kaydını göster

dc.contributor.authorNursal, Ayşe Feyda
dc.contributor.authorİnanır, Ahmet
dc.contributor.authorRüstemoğlu, Aydın
dc.contributor.authorUzun, Süheyla
dc.contributor.authorŞahin, Kübra
dc.contributor.authorYiğit, Serbülent
dc.date.accessioned2019-05-13T09:07:14Z
dc.date.available2019-05-13T09:07:14Z
dc.date.issued2019
dc.identifier.citationNursal, A. F., İnanır, A., Rüstemoğlu, A., Uzun, S., Şahin, K., Yiğit, S. (2019).Il-1β and IL-1Ra variant profiles in Turkish patients with diabetic peripheral neuropathy. Endocrine, Metabolic and Immune Disorders - Drug Targets,19(2),150-158.en_US
dc.identifier.issn1871-5303
dc.identifier.urihttps://doi.org/10.2174/1871530318666181022165048
dc.identifier.urihttps://hdl.handle.net/11491/1755
dc.description.abstractBackground: Diabetic peripheral neuropathy (DPN) is one of the most common complications of Type 2 diabetes mellitus (T2DM). This study was conducted to investigate the possible association between interleukin-1β (IL-1β) rs16944 /IL-1 receptor antagonist (IL-1Ra) VNTR variants and genetic susceptibility to DPN in a Turkish cohort Methods: A total of 200 subjects were enrolled in this study, 98 patients with DPN and 102 cases of age and sex-matched healthy controls. Genotyping was performed for all individuals using PCR-RFLP analysis Results: IL-1β rs16944 CC genotype had a 3.20-fold increased risk for DPN (p=0.0003, OR=3.20, 95% Cl:1.72-5.96). IL-1β rs16944 CT genotype was higher in healthy control than patients (p=0.004). IL-1β rs16944 C allele was higher in the patient group compared to controls while T allele was lower in patients than controls (p=0.003). IL-1Ra VNTR a1/a1 and a2/a2 genotypes were lower in DPN patients while a1/a2 genotype was higher in patients (p=0.045). The patients carrying a1/T haplotype had decreased risk of DPN than control groups (p=0.004). The patients carrying a2/a2 genotype had lower HDL level (p=0.039). The subjects carrying a2/a2 genotype had higher total cholesterol level while the subjects carrying a1/a2 genotype had lower total cholesterol (p=0.026 and p=0.037, respectively). IL-1Ra a1 allele was associated with higher HDL level (p=0.041) Conclusion: Findings of this study indicated that the IL-1β rs16944 and IL-1Ra VNTR variants are probably to be associated with susceptibility DPN risk in a Turkish cohort.en_US
dc.language.isoeng
dc.publisherBentham Science Publishers B.V.en_US
dc.relation.isversionof10.2174/1871530318666181022165048en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectType 2 Diabetes Mellitusen_US
dc.subjectDiabetic Peripheral Neuropathyen_US
dc.subjectInterleukin-1βen_US
dc.subjectInterleukin-1Raen_US
dc.subjectIL-1Ra VNTR Variantsen_US
dc.subjectDPN Risken_US
dc.titleIl-1β and IL-1Ra variant profiles in Turkish patients with diabetic peripheral neuropathyen_US
dc.typearticleen_US
dc.relation.journalEndocrine, Metabolic and Immune Disorders - Drug Targetsen_US
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.authorid0000-0001-7639-1122en_US
dc.identifier.volume19en_US
dc.identifier.issue2en_US
dc.identifier.startpage150en_US
dc.identifier.endpage158en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


Bu öğenin dosyaları:

DosyalarBoyutBiçimGöster

Bu öğe ile ilişkili dosya yok.

Bu öğe aşağıdaki koleksiyon(lar)da görünmektedir.

Basit öğe kaydını göster