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dc.contributor.authorSay Coşkun, Umut Safiye
dc.contributor.authorNursal, Ayşe Feyda
dc.contributor.authorGüneş, Ferda
dc.contributor.authorRüstemoğlu, Aydın
dc.contributor.authorYaylı, Abdullah
dc.contributor.authorKarakuş, Nevin
dc.contributor.authorBarut, Hüseyin Şener
dc.contributor.authorYiğit, Serbülent
dc.date.accessioned2019-05-13T09:07:49Z
dc.date.available2019-05-13T09:07:49Z
dc.date.issued2019
dc.identifier.citationSay Coşkun, U. S., Nursal, A. F., Güneş, F., Rüstemoğlu, A., Yaylı, A., Karakuş, N., Yiğit, S. (2019). Significance of IL-1Ra and IL-6 gene variants in Turkish patients with Crimean-Congo hemorrhagic fever. Asian Pacific Journal of Tropical Biomedicine, 9(2), 85-90.en_US
dc.identifier.issn2221-1691
dc.identifier.urihttps://doi.org/10.4103/2221-1691.250864
dc.identifier.urihttps://hdl.handle.net/11491/1881
dc.description.abstractObjective: To investigate the association between IL-1Ra variable number of tandem repeat (rs2234663), IL-6 -597GA (rs1800797), IL-6 -572GC (rs1800796) and the risk of Crimean-Congo hemorrhagic fever (CCHF) in the Turkish patients. Methods: This study included 50 patients infected with CCHF and 50 healthy controls. These variants were genotyped using polymerase chain reaction and/or restriction fragment length polymorphism method. Results: The distribution of the IL-6 -572GC genotypes and alleles varied significantly between the patients and the controls. The subjects carrying IL-6 -572GC GG genotype and G allele had increased risk of developing CCHF compared to the control group (P=0.006, P=0.014, respectively). IL-6 -572GC GC genotype was higher in the controls than the patients (P=0.006). For the triple genotype combinations, the 1/2-GC-GG genotype combination was detected more frequently in the control group than CCHF patients (P=0.016). IL-6 (-572/-597) GG-GG genotype was significantly higher in the patient group (P=0.015), while the GC-GG genotype was significantly lower in the patient group (P=0.005). Additionally, the G-G haplotype was significantly higher in the patient group (P=0.042), whereas C-G was found to be significantly lower in the patients than the control group (P=0.037). Conclusions: The results of this study suggest the IL-6 -572GC variant might be genetic markers of sensitivity to CCHF in the Turkish population and may facilitate greater protection against the disease. © 2019 Asian Pacific Journal of Tropical Biomedicine Produced by Wolters Kluwer-Medknow.en_US
dc.language.isoeng
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.isversionof10.4103/2221-1691.250864en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)*
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subject-572GCen_US
dc.subjectCrimean-Congo Hemorrhagic Feveren_US
dc.subjectIL-1Raen_US
dc.subjectIL-6en_US
dc.subjectVariable Number of Tandem Repeaten_US
dc.subject-597GAen_US
dc.titleSignificance of IL-1Ra and IL-6 gene variants in Turkish patients with Crimean-Congo hemorrhagic feveren_US
dc.typearticleen_US
dc.relation.journalAsian Pacific Journal of Tropical Biomedicineen_US
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.authorid0000-0001-7639-1122en_US
dc.identifier.volume9en_US
dc.identifier.issue2en_US
dc.identifier.startpage85en_US
dc.identifier.endpage90en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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