Effects of caffeic acid phenethyl ester on testicular torsion/detorsion injury in rats
MetadataShow full item record
Citationİpek, H., Doğan, G., Doğan, G. Deveci, E. (2018). Effects of caffeic acid phenethyl ester on testicular torsion/detorsion injury in rats. Analytical and Quantitative Cytopathology and Histopathology, 40(6), 270-276.
OBJECTIVE: To investigate the protective effect of caffeic acid phenethyl ester (CAPE) on testicular torsion/detorsion-induced ischemia-reperfusion (I/R) injury. STUDY DESIGN: Thirty male Wistar albino rats were randomly categorized into 3 groups: Sham, torsiondetorsion (T/D), and T/D+CAPE. Malondialdehyde (MDA), SOD, CAT, GSH levels, histopathological damage, and expression levels of endothelin-1 and ADAM-15 were examined in testicular tissue. RESULTS: The MDA level in the T/D group testes were significantly higher than those in the sham group. MDA levels of testes were lower in the CAPE-treated group than those in the T/D group. The T/D group had significantly lower SOD, CAT, and GSH levels in the testes than did the sham group. SOD, CAT, and GSH levels of the testes were lower in the CAPE-treated group than in the T/D group. In T/D group the thickness of the basal membrane in the tubules was increased, and degeneration and apoptosis in spermatogenetic cells, organization disorder in Sertoli cells, and sperm cells in the lumen were observed. The CAPE-treated group showed less atrophy and degeneration of the tubule epithelium than did the T/D group. CONCLUSION: It has been thought that CAPE administration after T/D testis damage may affect spermatogenesis development by inducing cell-cell junction by reducing apoptotic development which can regulate blood flow and microcirculation in testes. © 2018 Science Printers and Publishers, Inc.
SourceAnalytical and Quantitative Cytopathology and Histopathology
Showing items related by title, author, creator and subject.
Simvastatin Treatment Prevents Cell Damage and Regulates Angiogenesis in a Rat Ovarian Torsion and Detorsion Model An Immunohistochemical Study of Caspase-3 and sFlt-1 Expression OBJECTIVE: Ovarian torsion is a condition that affects the development of ovaries and restricts blood flow. It occurs most frequently in women of reproductive age, and delay in torsion resolution may result in necrosis and ...
Estimating the time of onset of testicular torsion using ultrasonography in an experimental rat model Song, Sang Hoon; Afsarlar, Cagatay E.; Xie, Hui Wen; Hung, Andrew J.; Koh, Chester J. (Korean Soc Ultrasound Medicine, 2020)Purpose: We aimed to document the time of onset of ultrasonographic and histologic changes in the testes of a rat model following testicular torsion. Methods: Twenty-five Sprague-Dawley rats were divided into four groups. ...
Ekici, Musa; Özgür, Berat Cem; Şentürk, Aykut Buğra; Nalbant, İsmail (College of Physicians and Surgeons Pakistan, 2018)Objective: To determine whether there is a correlation between seasonal temperature change and frequency of testicular torsion. Study Design: An observational study. Place and Duration of Study: Departments of Urology, ...