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dc.contributor.authorGücer, Firdevs İkbal
dc.contributor.authorŞentürk, Senem
dc.contributor.authorÖzkanlı, Şeyma
dc.contributor.authorYılmabasar, Mehmet Gökçe
dc.contributor.authorAdalı Köroglu, Gupse
dc.contributor.authorAcar, Murat
dc.date.accessioned2019-05-13T09:08:12Z
dc.date.available2019-05-13T09:08:12Z
dc.date.issued2015
dc.identifier.citationGücer, F. I., Senturk, S., Özkanli, S., Yilmabasar, M. G., Köroglu, G. A., & Acar, M. (2015). Evaluation of Crohn’s disease activity by MR enterography: derivation and histopathological comparison of an MR-based activity index. European journal of radiology, 84(10), 1829-1834.en_US
dc.identifier.issn0720-048X
dc.identifier.urihttps://doi.org/10.1016/j.ejrad.2015.06.005
dc.identifier.urihttps://hdl.handle.net/11491/1954
dc.description.abstractAims To compose a qualitative magnetic resonance imaging (MRI) activity index showing Crohn disease (CD) activity, and to compare magnetic resonance enterography (MRE) findings with histopathology results. Materials and methods Twenty-six patients (11 male and 15 female; mean age 36.7) who had MRE and colonoscopic biopsy between October 2011 and August 2012 were included in the study. On MRE the following parameters were evaluated: bowel wall thickness, bowel wall T2 signal, bowel wall contrast enhancement pattern and degree, length and number of involved bowel segments, perimural T2 signal, mesenteric inflammation, mesenteric lymph nodes and complications of CD. Each parameter was scored to calculate MRI activity index. Biopsy specimens were retrospectively evaluated, histopathologic and endoscopic acute inflammmation scores (AIS, eAIS) were calculated. Each parameter and total MRI activity index were compared with the pathology scores (AIS, eAIS) by Mann-Whitney U test and Spearman correlation. Results Statistically significant positive correlation was found between AIS and eAIS, mural thickness and eAIS. Moderate correlation was found between MRI activity index and eAIS, mural enhancement degree and eAIS; and poor correlation was found between mesenteric inflammation score and eAIS, MRI activity index and AIS, however they were not statistically significant. Conclusions In CD, bowel wall thickness measured by MRE is best correlated with the histopathologic results which are accepted as the reference standard. In cases with high MRI activity index, eAIS is also generally high. MRI activity index which is measured simply and noninvasively can be used in the follow up of CD. © 2015 Elsevier Ireland Ltd. All rights reserved.en_US
dc.language.isoeng
dc.publisherElsevier Ireland Ltden_US
dc.relation.isversionof10.1016/j.ejrad.2015.06.005en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcute Inflammmation Scoreen_US
dc.subjectCrohn Diseaseen_US
dc.subjectEndoscopic Acute Inflammation Scoreen_US
dc.subjectMagnetic Resonance Activity Indexen_US
dc.subjectMagnetic Resonance Enterographyen_US
dc.titleEvaluation of Crohn's disease activity by MR enterography: Derivation and histopathological comparison of an MR-based activity indexen_US
dc.typearticleen_US
dc.relation.journalEuropean Journal of Radiologyen_US
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.identifier.volume84en_US
dc.identifier.issue10en_US
dc.identifier.startpage1829en_US
dc.identifier.endpage1834en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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