Nanosized Drug Carriers for Oral Delivery of Anticancer Compounds and the Importance of the Chromatographic Techniques
Cancer is the primary leading cause of mortality in the world. The key of a successful cancer treatment depends on many important parameters, such as the application route, anticancer compound, and dosage form. Among the administration routes, oral application is the most widely used application method. However, oral administration of many molecules as conventional dosage forms is limited due to a major problem-low bioavailability. Nanoscale drug delivery systems can ensure oral administration and improve the oral bioavailability of the drugs. Determination of the chemotherapeutically active molecules from the developed nanoscale systems has an important role in the effectiveness of the nanoparticles. Chromatographic techniques, especially liquid chromatography, are very suitable and accurate ways to determine the content of a pharmaceutical ingredient and its stability in both in vitro and in vivo systems. This chapter describes the importance of lipid- and polymer-based nanoscale drug delivery technologies of the anticancer molecules and summarizes the effect and type of the nanostructures, characterization parameters, analysis parameters, such as column types and mobile phase compositions, and validation parameters. © 2017 Elsevier Inc. All rights reserved.