Yazar "Gümüştaş, Mehmet" için Makale Koleksiyonu listeleme
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Determination of pK a values of cefdinir and cefixime by LC and spectrophotometric methods and their analysis in pharmaceutical dosage forms
Şanlı, Nurullah; Şanlı, Senem; Sızır, Ümit; Gümüştaş, Mehmet; Özkan, Sibel Ayşıl (Friedr. Vieweg und Sohn Verlags GmbH, 2011)The pK a values of cefdinir and cefixime, which are used in the treatment of bacterial infections, have been determined precisely in water and methanol-water binary mixtures (20% v/v) using spectrophotometric titration and ... -
Determination of pKa values of some antihypertensive drugs by liquid chromatography and simultaneous assay of lercanidipine and enalapril in their binary mixtures
Gümüştaş, Mehmet; Şanlı, Senem; Şanlı, Nurullah; Özkan, Sibel Ayşıl (Elsevier B.V., 2010)In this study, pKa values were determined using the dependence of the retention factor on the pH of the mobile phase for three ionizable substances, namely, enalapril, lercanidipine and ramipril (IS). The effect of the ... -
Development and validation of a liquid chromatographic method for concurrent assay of weakly basic drug verapamil and amphoteric drug trandolapril in pharmaceutical formulations
The analysis of weakly basic drugs such as verapamil by reverse-phase liquid chromatography remains a problem, particularly when present in combination with other drugs such as amphoteric compounds like trandolapril. In ... -
Development and validation of a stability-indicating RP-LC method for the determination of anticancer drug epirubicin in pharmaceuticals
Kurbanoğlu, Sevinç; Bozal Palabıyık, Burçin; Gümüştaş, Mehmet; Şanlı, Senem; Uslu, Bengi; Özkan, Sibel Ayşıl (Taylor and Francis Inc., 2014)In the present paper, sensitive, rapid, and different analytical methodology was developed for the determination of anticancer drug epirubicin (EPR). The mixture of epirubicin and moxifloxacin as internal standard was ... -
Development of a HILIC method for the determination of 5-fluorouracil from nano drug delivery systems and rat skin extracts
Amasya, Gülin; Gümüştaş, Mehmet; Badıllı, Ulya; Özkan, Sibel Ayşıl; Tarımcı, Nilüfer (Elsevier B.V., 2018)This is the first report in literature using hydrophilic interaction liquid chromatography (HILIC) in combination with diode array detector (DAD) for stability indicating determination of 5-Fluorouracil (5-FU) from its ... -
Electroanalytical characteristics of antipsychotic drug ziprasidone and its determination in pharmaceuticals and serum samples on solid electrodes
Kul, Dilek; Gümüştaş, Mehmet; Uslu, Bengi; Özkan, Sibel Ayşıl (Elsevier B.V., 2010)Ziprasidone is a psychotropic agent used for the treatment of schizophrenia. Its oxidation was investigated electrochemically at boron-doped diamond and glassy carbon electrodes using cyclic, differential pulse, and square ... -
Fully validated simultaneous determination of bisoprolol fumarate and hydrochlorothiazide in their dosage forms using different voltammetric, chromatographic, and spectrophotometric analytical methods
Bozal Palabıyık, Burçin; Gümüştaş, Mehmet; Doğan Topal, Burcu; Uslu, Bengi; Özkan, Sibel Ayşıl (2013)Voltammetric, chromatographic, and spectrophotometric methods were developed for the simultaneous determination of bisoprolol fumarate (BIS) and hydrochlorothiazide (HCZ). Differential pulse and square wave voltammetry ... -
Fulvestrant-loaded polymer-based nanoparticles for local drug delivery: Preparation and in vitro characterization
Hasçiçek, Canan; Şengel Türk, Ceyda Tuba; Gümüştaş, Mehmet; Özkan, Sibel Ayşıl; Bakar, Filiz; Daş Evcimen, Net; Savaşer, Ayhan; Özkan, Yalçın (Editions de Sante, 2017)The present investigation was aimed at optimizing Fulvestrant (FLV)-loaded nanoparticulate formulations to overcome side effects caused by the intramuscular injection of FLV, and to prolong local intratumoral action at ... -
Investigation of voltammetric behavior and electroanalytical determination of anticancer epirubicin via glassy carbon electrode using differential pulse and square wave voltammetry techniques
Kurbanoğlu, Sevinç; Bozal Palabıyık, Burçin; Gümüştaş, Mehmet; Uslu, Bengi; Özkan, Sibel Ayşıl (Editions de l'Academie Republique Populaire, 2015)The electrochemical oxidation of epirubicin was investigated using cyclic, differential pulse and square wave voltammetry at glassy carbon electrode. The aim of the study was to determine epirubicin levels in pharmaceuticals ... -
Modern Assay Techniques for Cancer Drugs: Electroanalytical and Liquid Chromatography Methods
Kurbanoğlu, Sevinç; Karadaş Bakırhan, Nurgül; Gümüştaş, Mehmet; Özkan, Sibel Ayşıl (Taylor and Francis Ltd., 2018)In the past decades, patients who have chemotherapy treatment have considerably increased number. At this point, the development of rapid precise, and reliable methods are very important to analyze cancer drugs from their ... -
A novel core-shell-based chromatographic method supported by ratio derivative spectrophotometry for the simultaneous determination of perindopril, indapamide, and amlodipine ternary mixtures
Karadurmuş, Leyla; Gümüştaş, Mehmet; Kurbanoğlu, Sevinç; Uslu, Bengi; Özkan, Sibel Ayşıl (TUBİTAK, 2018)In this work, ratio spectra of the frst derivative spectrophotometric and liquid chromatographic methods have been described for the frst time for the simultaneous determination of perindopril (PER), indapamide (IND), and ... -
Optimization of stability indicating LC method for the sensitive in vitro determination from solid lipid nanoparticles and ex vivo analysis from rat skin of etofenamate
Gümüştaş, Mehmet; Şengel Türk, Ceyda Tuba; Badıllı, Ulya; Amasya, Gülin; Özkan, Sibel Ayşıl; Tarımcı, Nilüfer (Bentham Science Publishers B.V., 2017)Introduction: Etofenamate (2-(2-hydroxyethoxy) ethyl 2-[[3-(trifluoromethyl)phenyl]amino] benzoate) (ETO) is a yellowish viscous liquid which is a nonsteroidal anti-inflammatory drug (NSAID) that has been applied topically ... -
A sensitive and selective RP-LC method for the simultaneous determination of the antihypertensive drugs, enalapril, lercanidipine, nitrendipine and their validation
A RP-LC method is presented, which is sensitive and selective for the simultaneous determination of enalapril-lercanidipine and enalapril-nitrendipine binary mixtures in their pharmaceutical dosage forms. The analyte peaks ... -
Separation and elution order of the enantiomers of some beta-agonists using polysaccharide-based chiral columns and normal phase eluents by high-performance liquid chromatography
Gümüştaş, Mehmet; Özkan, Sibel Ayşıl; Chankvetadze, Bezhan (Elsevier B.V., 2016)In this study separation of enantiomers of 8 chiral ?-agonists were studied on 6 polysaccharide-based chiral columns in polar-organic and alcohol-hydrocarbon mobile phases. No separation of enantiomers was observed on any ... -
Simple, sensitive and reliable LC-DAD method of gemifloxacin determination in pharmaceutical dosage forms
Gümüştaş, Mehmet; Özkan, Sibel Ayşıl (2012)A sensitive, accurate, rapid, fully validated, reliable and easy method was developed for the quantification of gemifloxacin mesylate (GEM) using liquid chromatography (LC) with DAD detection. In this method; a reversed-phase ... -
Simultaneous determination and validation of emtricitabine, rilpivirine and tenofovir from biological samples using LC and CE methods
Gümüştaş, Mehmet; Çağlayan, Mehmet Gökhan; Onur, Feyyaz; Özkan, Sibel Ayşıl (John Wiley and Sons Ltd, 2018)A combination of antiretroviral agents is frequently used in effective treatment of the human immunodeficiency virus infection. In this study, two different separation methods are presented for the simultaneous determination ... -
Simultaneous determination and validation of some binary mixtures of antihypertensive drugs using ratio derivative spectrophotometric method
Kurbanoğlu, Sevinç; Gümüştaş, Mehmet; Özkan, Sibel Ayşıl (Maik Nauka Publishing / Springer SBM, 2014)Ratio derivative spectrophotometric technique is presented for the rapid, accurate and precise simultaneous determination of olmesartan medoxomil (OLM), hydrochlorothiazide (HCT), and zofenopril (ZOF) as well as HCT binary ... -
Simultaneous determination of amlodipine besylate and rosuvastatin calcium in binary mixtures by voltammetric and chromatographic techniques
Karadaş Bakırhan, Nurgül; Gümüştaş, Mehmet; Uslu, Bengi; Özkan, Sibel Ayşıl (Institute for Ionics, 2016)Voltammetric and liquid chromatographic (LC) methods have been developed for the simultaneous determination of amlodipine besylate (AML) and rosuvastatin calcium (ROS) for the first time. Detailed electrochemical behavior ... -
Simultaneous estimation and validation of some binary mixtures of antihypertensive drugs by RP-LC methods using two new generation silica columns
Kurbanoğlu, Sevinç; Gümüştaş, Mehmet; Özkan, A. S. (Elsevier B.V., 2013)Two reversed phase liquid chromatographic (RP-LC) techniques are presented for the rapid, accurate, precise, simultaneous determination of olmesartan-hydrochlorothiazide and zofenopril-hydrochlorothiazide binary mixtures ... -
Simultaneous estimation of ceftazidime and ceftizoxime in pharmaceutical formulations by HPLC method
Şanlı, Senem; Şanlı, Nurullah; Gümüştaş, Mehmet; Özkan, Sibel Ayşıl; Karadaş, Nurullah; Aboul-Enein, Hassan Y. (2011)The aim of the present study was to develop a fast, sensitive and reliable method for rapid screening of cephalosporin injectable dosage forms namely ceftazidime and ceftizoxime to the detection of counterfeit and substandard ...