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Alpha-tocopherol decreases iron-induced hippocampal and nigral neuron loss
There are many studies about iron-induced neuronal hyperactivity and oxidative stress. Some reports also showed that iron levels rise in the brain in some neurodegenerative diseases such as Parkinson’s (PD) and Alzheimer’s ...
Demirin neden olduğu purkinje hücre kaybı üzerine nitrik oksit sentaz inhibisyonunun koruyucu etkisi
Amaç: Demir, nöronal hiperaktivite ve oksidatif stresi indüklemek için sıklıkla kullanılan bir metaldir. Nitrik oksit sentaz (NOS) tarafından sentezlenen nitrik oksit ile hücre ölümü arasındaki ilişkiyi ortaya koyan bulgular ...
Blocking of L-type calcium channels protects hippocampal and nigral neurons against iron neurotoxicity: The role of L-type calcium channels in iron-induced neurotoxicity
(Informa Healthcare, 2013)
Iron plays an important role in maintaining normal brain function. However, iron overload and enhanced hydroxyl radical formation have been implicated as the causative factors of some neurodegenerative disorders such as ...
Role of nitric oxide synthesis inhibitors in iron-induced nigral neurotoxicity: A mechanistic exploration
In the central nervous system, nitric oxide (NO) has been suggested to be a cell-to-cell signaling molecule that regulates guanylyl cyclase, aconitase, and iron regulatory protein. NO is also one of the substances that is ...
Iron-induced cerebellar purkinje cell loss is ameliorated by flunarizine
(Türkiye Bilimsel ve Teknolojik Araştırma Kurumu (TÜBİTAK), 2009)
Aim: In this study, we investigated the effect of intracerebroventricular-injected iron neurotoxicity on the total number of cerebellar Purkinje cells in rats and the possible neuroprotective effect of flunarizine, a ...