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dc.contributor.authorÖzkahraman, Bengi
dc.contributor.authorTamahkar Irmak, Emel
dc.date.accessioned2019-06-13T06:29:37Z
dc.date.available2019-06-13T06:29:37Z
dc.date.issued2017
dc.identifier.citationÖzkahraman, B., Tamahkar Irmak, E. (2017). Carbon nanotube based polyvinylalcohol-polyvinylpyrolidone nanocomposite hydrogels for controlled drug delivery applications. Anadolu Üniversitesi Bilim ve Teknoloji Dergisi A-Uygulamalı Bilimler ve Mühendislik, 18(3), 543-553.en_US
dc.identifier.issn1302-3160
dc.identifier.urihttps://hdl.handle.net/11491/3328
dc.descriptionresearchen_US
dc.description.abstractControlled drug release systems present a significant alternative to the conventional drug dosages providing drug release for prolonged time periods. Nanocomposite hydrogels offer an important potential for drug release with enhanced physicochemical properties. In this study, the preparation of carbon nanotube (CNT)-based Polyvinylalcohol-Polyvinylpyrolidone (PVA/PVP) nanocomposite hydrogels namely, CNT-25, CNT-50 and CNT-100 were succeedded via the freeze/thawing method with the addition of different amounts of CNT. The nanocomposite hydrogels were characterized by swelling tests, SEM, FTIR, DSC and BET measurements. It was determined that CNT-50 was the most suitable hydrogel for drug release studies having better morphological properties with homogenous distribution of CNT throughout the polymeric nanocomposite matrix. The release of 5-fluororacil (5-FU) as a model drug was investigated in-vitro. The release of 5-FU from CNT-based PVA/PVP nanocomposite hydrogels was exhibited controlled release for one week at pH 7.4. The amount of released 5-FU was effectively increased with the addition of CNT into the hydrogel matrix. Korsmeyer-Peppas model was well fitted for determining the release mechanism of 5-FU from CNT-based PVA/PVP nanocomposite hydrogels corresponding the combination of diffusion of the drug and the dissolution of polymer chains.en_US
dc.language.isoengen_US
dc.publisherEskişehir Teknik Üniversitesien_US
dc.relation.isversionof10.18038/aubtda.322138en_US
dc.subjectDrug Release Systemsen_US
dc.subjectNanocomposite Hydrogelsen_US
dc.subjectCarbon Nanotubeen_US
dc.subjectPVA/PVP Hydrogelsen_US
dc.titleCarbon nanotube based polyvinylalcohol-polyvinylpyrolidone nanocomposite hydrogels for controlled drug delivery applicationsen_US
dc.typearticleen_US
dc.relation.journalAnadolu Üniversitesi Bilim ve Teknoloji Dergisi A-Uygulamalı Bilimler ve Mühendisliken_US
dc.contributor.departmentPolimer Mühendisliği Bölümüen_US
dc.contributor.departmentKimya Mühendisliği Bölümüen_US
dc.contributor.authorID0000-0003-1535-4381en_US
dc.contributor.authorID0000-0002-5913-8333en_US
dc.identifier.volume18en_US
dc.identifier.issue3en_US
dc.identifier.startpage543en_US
dc.identifier.endpage553en_US


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