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dc.contributor.authorÜlger, Fatma
dc.contributor.authorBozkurt, Ayhan
dc.contributor.authorBilge, S. Sırrı
dc.contributor.authorİlkaya, Fatih
dc.contributor.authorDilek, Ahmet
dc.contributor.authorBostancı, Mehmet Ömer
dc.contributor.authorÇiftçioğlu, Engin
dc.contributor.authorGüldoğuş, Fırat
dc.date.accessioned2019-05-10T09:38:47Z
dc.date.available2019-05-10T09:38:47Z
dc.date.issued2009
dc.identifier.citationÜlger, F., Bozkurt, A., Bilge, S. S., Ilkaya, F., Dilek, A. N., Bostancı, M .Ö., Çiftcioğlu, E., Güldoğuş, F. (2009). The antinociceptive effects of intravenous dexmedetomidine in colorectal distension-induced visceral pain in rats: the role of opioid receptors. Anesthesia and analgesia, 109 (2), 616-622 .en_US
dc.identifier.issn0003-2999
dc.identifier.urihttps://doi.org/10.1213/ane.0b013e3181a9fae2
dc.identifier.urihttps://hdl.handle.net/11491/471
dc.description.abstractBACKGROUND: In comparison with cutaneous pain, the role of ?2-adrenoceptor (?2-AR) agonists in visceral pain has not been extensively examined. We aimed to characterize the antinociceptive effect of IV dexmedetomidine on visceral pain in rats and to determine whether antinociception thus produced is mediated by opioid receptors. METHODS: Male Sprague Dawley rats (250-300 g) were instrumented with a venous catheter for drug administration and with enameled nichrome electrodes for electromyography of the external oblique muscles. Colorectal distension (CRD) was used as the noxious visceral stimulus, and the visceromotor response to CRD was quantified electromyographically before and 5, 15, 30, 60, 90, and 120 min after dexmedetomidine or clonidine administration. Antagonists were administered 10 min before dexmedetomidine. After confirmation of normal distribution of data, one-way analysis of variance with the Tukey-Kramer post hoc test was used for multiple comparison. RESULTS: IV administration of dexmedetomidine (2.5-20 ?g/kg) and clonidine (10-80 ?g/kg) produced a dose-dependent reduction in visceromotor response with 50% effective dose values of 10.5 and 37.6 ?g/kg, respectively. Administration of the nonspecific ?2-AR antagonist yohimbine (1 mg/kg), but not the peripherally restricted ?2-AR antagonist MK-467 (1 mg/kg), abolished the antinociceptive effect of dexmedetomidine (10 ?g/kg). In addition, inhibition of opioid receptors by naloxone (1 mg/kg) attenuated the antinociceptive effect of dexmedetomidine. CONCLUSION: Our data indicate that IV dexmedetomidine exerts pronounced antinociception against CRD-induced visceral pain and suggest that the antinociceptive effect of dexmedotimidine is mediated in part by opioid receptors, but peripheral ?2-ARs are not involved. Copyright © 2009 International Anesthesia Research Society.en_US
dc.language.isoeng
dc.publisherLippincott Williams and Wilkinsen_US
dc.relation.isversionof10.1213/ane.0b013e3181a9fae2en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[Belirlenecek]en_US
dc.titleThe antinociceptive effects of intravenous dexmedetomidine in colorectal distension-induced visceral pain in rats: The role of opioid receptorsen_US
dc.typearticleen_US
dc.relation.journalAnesthesia and Analgesiaen_US
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.identifier.volume109en_US
dc.identifier.issue2en_US
dc.identifier.startpage616en_US
dc.identifier.endpage622en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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