eNOS and XRCC4 VNTR variants contribute to formation of nicotine dependence and/or schizophrenia
Uysal, Mehmet Ali
Aydın, Pelin C.
Nursal, Ayşe Feyda
Yavuz, Ferhat K.
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CitationPehlivan, S., Uysal, M.A., Aydin, P., Pehlivan, M., Nursal, A.F., Yavuzlar, H., Kurnaz, S., Sever, U., Yavuz, F., Uysal, S., & Aydin, N. (2017). eNOS and XRCC4 VNTR variants contribute to formation of nicotine dependence and/or schizophrenia. Bratislavske lekarske listy, 118 (8), 467-471 .
BACKGROUND: This study aimed to evaluate whether VNTR variants in the Endothelial Nitric Oxide Synthase (eNOS) and the XRCC4 gene play any role in nicotine dependence (ND) and/or Schizophrenia+ND (Sch+ND) ethiopathogenesis. METHODS: Present study included 100 individuals with ND, 60 patients with Sch+ND, and 70 healthy controls. These variants were analyzed using PCR. RESULTS: The cases with ND had higher eNOS VNTR-BB genotype than the healthy control subjects (p = 0.001). eNOS-AA genotype was lower in cases with Sch+ND and ND groups compared to the controls (p = 0.001, p = 0.001, respectively). eNOS-B allele was found significantly more frequently in Sch+ND group compared to the controls (p = 0.001). eNOS-A allele was significantly lower in ND group than the controls (p = 0.001). XRCC4-ID genotype was more common in the ND group than the control group (p = 0.001) as heterozygosity disadvantage. XRCC4-DD genotype was more common in the Sch+ND group compared to the controls (p = 0.035). The frequency of XRCC4-I allele was lower in the Sch+ND group compared to the controls (p = 0.012). CONCLUSIONS: Our results showed that eNOS and XRCC4 VNTR variants might play a potential role in Sch+ND and/or ND pathophysiology.