Thiol/disulfide homeostasis in patients with telogen effluvium: is oxidative stress important in the pathogenesis of telogen effluvium?
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Erişim
info:eu-repo/semantics/openAccessTarih
2019Yazar
Savcı, ÜnsalŞahin, Mustafa
Şenel, Engin
Öztekin, Aynure
Muslu, Ümran
Sungur, Mustafa
Neşelioğlu, Salim
Erel, Özcan
Üst veri
Tüm öğe kaydını gösterKünye
Savci U, Sahin M, Senel E, Oztekin A, Muslu U, Sungur M, et al. (2019). Thiol/disulfide homeostasis in patients with telogen effluvium: Is oxidative stress important in the pathogenesis of telogen effluvium? Turk J Dermatol, 13(4) :131-4.Özet
Objective: The aim of this study was to assess the correlation between telogen effluvium (TE) with the new oxidative stress (OS) indicator of thiol/disulfide balance and to research the role of OS in the pathogenesis of TE. Methods: Our study included 101 patients with TE diagnosis and 39 healthy individuals. Serum thiol/disulfide was measured with a new automated spectrometric method developed by Erel and Neselioglu, and results were compared statistically. Results: Among the six thiol/disulfide parameters, there were statistically significant differences for native thiol, total thiol, disulfide, disulfide/native thiol, disulfide/total thiol, and native thiol/total thiol studied in the patient and control groups (P = 0.042, 0.044, < 0.001, respectively). Conclusions: Based on the results of this study, it can be said that OS is closely associated with TE pathogenesis. There is a need for new studies that will show the possible effects of OS on TE pathogenesis and research different OS markers in addition to thiol/disulfide parameters.
Kaynak
Turkish Journal of DermatologyCilt
13Sayı
4Bağlantı
http://www.tjdonline.org/temp/TurkJDermatol134131-2529571_070135.pdfhttps://hdl.handle.net/11491/5657
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