Yazar "Nursal, Ayşe Feyda" için TR-Dizin İndeksli Yayınlar Koleksiyonu listeleme
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ACAN Gene VNTR Polymorphism and Intervertebral Disc Degeneration in a Turkish Population
Öz, Tuba; Kaya, İsmail; Nursal, Ayşe Feyda; Aydın, Hasan Emre; Demir, Osman; Yiğit, Serbülent (2020)Aim: Intervertebral disc degeneration (IVDD) is caused by several genetic and environmental factors. Aggrecan is the major component of intervertebral disk matrix proteoglycan with multiple functional domains. The aim of ... -
Association of Myeloperoxidase Gene Functional Variant with Schizophrenia and Smoking in a Turkish Population
Pehlivan, Sacide; Çetinay, Pınar; Uysal, M. Atilla; Nursal, Ayşe Feyda; Kurnaz, Selin; Sever, Ulgen; Pehlivan, Mustafa (2020)Objective: Etiopathogenesis of schizophrenia (SCZ) involves several risk genes that induce inflammation, environmental stress factors and changes in the innate immune system. Patients with SCZ have the highest rate of ... -
C Deletion in Exon 4 Codon 63 of p53 Gene in Turkish Patients with Oral Squamous Cell Carcinoma
Tekcan, Akın; Gümüşay, Özge; Nursal, Ayşe Feyda; Yiğit, Serbülent; Yıldız, Serkan; Tümer, Mehmet Kemal (2020)OBJECTIVE Oral squamous cell carcinoma (OSCC) is the most frequently seen oral malignancy and accounts for up to 80-90% of all malignant neoplasms that occurin the oral cavity. The p53 tumor suppressor gene plays a crucial ... -
Correlation of HER2/TOP2A Gene Aberrations with RASSF1A/APC Gene Methylation Status in High-Risk Breast Cancer
Nursal, Ayşe Feyda; Çilingir, Oğuz; Eroğlu, Onur; Aras, Beyhan Durak; Çiftci, Evrim; Baydemir, Canan; Artan, Sevilhan (2020)OBJECTIVE Breast cancer (BC) is a heterogeneous malignancy and differs widely among different patients. The aim of this study was to investigate the relationship between the HER2/TOP2A gene aberrations and promoter methylation ... -
Cytokine gene variants/expressions and non-syndromic microtia – Is there a link?
Nursal, Ayşe Feyda; Bekerecioğlu, Mehmet; Pehlivan, Sacide; Sever, Tuğçe; Büyükgüral, Berker (Continuing Education, and Scientific Research Association (CESRA), 2017)Sitokin gen varyantları/ekspresyonları ve non-sendromik mikrotia - Bir ilişki var mıdır?Amaç: Mikrotianın etyopatogenezinde birçok genetik ve çevreselfaktörler araştırılmasına rağmen hala belirsizlik vardır. Bu çalışmadabir ... -
Dopamine D4 Receptor Gene Exon III VNTR Variant Influences Smoking Status in Turkish Population
Uysal, Mehmet Atilla; Sever, Ülgen; Nursal, Ayşe Feyda; Group, Yedikule Smoking Cessation Study; Pehlivan, Sacide (2019)Introduction: Dopaminergic gene variants may affect nicotine dependence through their possible impact on the dopamine reward pathway. The purpose of this study is to investigate the relationship between the variable number ... -
Effect of the IL-17F rs763780 Variant on Chronic Lymphocytic Leukemia and Multiple Myeloma Risk in a Turkish Cohort
Introduction: Chronic lymphocytic leukemia (CLL) is one of the most common leukemias in developed countries. Multiple myeloma (MM), a clonal plasma cell disease, is the second most prevalent hematological cancer. Interleukin-17 ... -
Endotelyal nitrik oksit sentaz (eNOS) ve miyeloperoksidaz (MPO) genlerin mikrotiyadaki rolü
Amaç: Bu çalışmanın amacı endotelyal nitrik oksit sentaz (eNOS) polimorfizmleriyle miyeloperoksidaz (MPO) genleri ve mikrotiya gelişimi arasındaki ilişkiyi belirlemekti. Yöntem:Çalışmaya akraba olmayan 19 (11 erkek, 8 ... -
The endothelial nitric oxide synthase gene variants as a risk factor for chronic lymphocytic leukemia
Pehlivan, Mustafa; Tomatır, Ayşe G.; Nursal, Ayşe Feyda; Şahin, Handan H.; Pehlivan, Sacide (Akademi Doktorlar Yayınevi, 2017)Nitric oxide (NO) plays complicated roles in carcinogenesis. Endothelial nitric oxide synthase (eNOS) gene is responsible for most of the NO produced. For this reason, it was considered that the eNOS gene variants is ... -
Genetic Variations of miRNAs and the Risk of Oral Squamous Cell Carcinoma: A Case-control Study
Aim: In this study, we investigated the association between two miRNA variants and the risk of oral squamous cell carcinoma (OSCC), and explored the interaction between clinical factors in the Turkish population. Methods: ... -
Impact of the Functional VNTR Variants of the Interleukin-1 Receptor Antagonist and Interleukin-4 Genes on Oral Squamous Cell Carcinoma
Introduction: It has been shown that the host immune response and chronic inflammation could play a role as important risk factors for cancer. Oral squamous cell carcinoma (OSCC) is a common cancer worldwide. In this study, ... -
Impact of UCP2 -866G/A Variant on Smoking Risk
Objective: Mitochondria are multifunctional and dynamic organelles found in cells. Nicotine is a natural alkaloid found in the tobacco plant and has been well studied as a component of cigarette smoke. It has also been ... -
Importance of anaplastic lymphoma kinase gene re-arrangements on non-small cell lung cancer
Nursal, Ayşe Feyda (Kafkas Üniversitesi Tıp Fakültesi, 2017)Despite all improvements in treatment modalities, lung cancer is the leading cause of death related to cancers worldwide. Environmental, occupational and genetic factors, as well as smoking play role in the etiology. ... -
Interleukin-1 gene variants and the risk of non-syndromic microtia
Nursal, Ayşe Feyda; Bekerecioğlu, Mehmet; Büyükgüral, Berker; Pehlivan, Sacide (Pamukkale Üniversitesi, 2018)Purpose: Microtia is a congenital anomaly, manifested by a small and disfigured auricle. Interleukin (IL) 1 is an important mediator of inflammation and cartilage destruction, This study is aimed at investigating association ... -
Investigation of the role of interleukin-1 receptor antagonist VNTR variant on the Behçet’s disease
Dursun, Gul; Nursal, Ayşe Feyda; Demir, Helin Deniz; Karakuş, Nevin; Demir, Osman; Yiğit, Serbülent (2018)Objective: Behçet’s disease (BD), a chronic multisystem inflammatory disorder, is mainly characterized by relapsing periods of a wide range of clinical symptoms. Several cytokine genes may play important roles in the ... -
Is Complement Factor H Tyr402His Variant a Potential Cause of Ankylosing Spondylitis?
Pehlivan, Sacide; Akaltun, Mazlum Serdar; Pehlivan, Mustafa; Gürsoy, Savaş; Nursal, Ayşe Feyda (2020)Aim: Ankylosing spondylitis (AS) is an autoimmune disease caused by chronic inflammatory response. Complement system is the major component of the innate immune defence. In this study, we investigated the potential association ... -
Is there any Association between the Functional Variants of the NOS3 Gene and Psoriasis?
Pehlivan, Sacide; İnalöz, Hüseyin Serhat; Nursal, Ayşe Feyda; Gülel, Aslıhan; Pehlivan, Mustafa (2018)Introduction: Psoriasis (Ps) is a chronic, immune-mediated inflammatory skin disorder with an incompletely understood etiology. The aim of this study was to investigate the relationship between the suspectibility to Ps and ... -
Küçük hücreli dışı akciğer kanserinde MET geninin güncel durumu
Nursal, Ayşe Feyda (Bozok Üniversitesi Tıp Fakültesi, 2016)Akciğer kanseri tüm dünyada kansere bağlı ölüm sebepleri içinde ilk sırada yer alır. Tedavi alanında tüm gelişmelere rağmen hala kötü prognoza sahiptir. Akciğer kanseri histolojik tipine göre küçük hücreli akciğer kanseri ... -
The MIF rs755622 Variant may Increase Susceptibility of Breast Cancer but not Gastrointestinal Cancer in a Turkish Population
Pehlivan, Sacide; Işıksaçan, Nilgün; Pehlivan, Mustafa; Günaldı, Meral; Oyacı, Yasemin; Nursal, Ayşe Feyda (2020)OBJECTIVE An increasing number of epidemiological and molecular evidence proposes that inflammation is a significant factor in the etiology of cancers. Macrophage Migration Inhibitory Factor (MIF) encodes a lymphokine ... -
THE miR-196a2T/C VARIANT AS A POSSIBLE PREDISPOSING FACTOR FOR ANKYLOSING SPONDYLITIS IN A TURKISH POPULATION
Pehlivan, Sacide; Gürsoy, Savaş; Nursal, Ayşe Feyda; Akaltun, Mazlum Serdar; Özdilli, Kürşat; Pehlivan, Mustafa (2020)Objective: Ankylosing spondylitis (AS) is a chronic inflammatory disorder. MicroRNAs (miRNAs) can function as either oncogenes or tumor suppressor genes. Altered miRNA expression has been implicated in the pathogenesis of ...