| dc.description.abstract | OBJECTIVE: We aimed to investigate the effects of recurrent sevoflurane anesthesia on cognitive functions in Alzheimer Disease. MATERIALS AND METHODS: Rats were divided into 4 groups as followed: control (Group C), sevoflurane (Group S), Alzheimer's (Group A) and Alzheimer's + sevoflurane (Group AS)]. Cognitive functions were evaluated with Radial Arm Maze Test (RAMT). Alzheimer model was created by administering 3 mg/kg (10 ?l) STZ. Sevoflurane was administered to S and AS groups. Serum samples and hippocampus tissues were analyzed. RESULTS: In RAM test, the entry-exit data were significantly decreased in A and AS groups. After the 2nd and 3rd administration of anesthesia, the numbers were significantly decreased in Group S. Glial-fibrillaryacidic protein levels were significantly higher in AS compared to the C and S groups. The brain tissue caspase 3 activity was less than 1% in all rats in the Group C, 3 % in 2 rats and 1 % in 1 rat in the Group AS. In A and AS group, serum catalase, myeloperoxidase and ferroxidase activities were found to be higher than in the other groups and myeloperoxidase activity was higher in the AS than in the A Group. Serum native thiol, total thiol and disulfi de levels were found to be significantly different in the A and AS groups. CONCLUSION: Sevoflurane anesthesia negatively affected the cognitive functions (Tab. 5, Fig. 10, Ref. 51). Text in PDF www.elis.sk. © 2019 Comenius University. | en_US |
| dc.department-temp | Erkent, F.D., Hitit University School of Medicine, Department of Anesthesiology and Reanimation, Corum, Turkey; Isik, B., Gazi University School of Medicine, Department of Anesthesiology and Reanimation, Ankara, Turkey; Kucuk, A., Kütahya Health Science University School of Medicine, Department of Physiology, Kütahya, Turkey; Ozturk, L., Yildirim Bayazit University School of Medicine, Department of Anesthesiology and Reanimation, Ankara, Turkey; Neselioglu, S., Yildirim Bayazit University School of Medicine, Department of Medical Biochemistry, Ankara, Turkey; Dogan, H.T., Yildirim Bayazit University School of Medicine, Department of Medical Pathology, Ankara, Turkey; Guney, S., Gazi University School of Medicine, Department of Physiology, Ankara, Turkey; Arslan, M., Gazi University School of Medicine, Department of Anesthesiology and Reanimation, Ankara, Turkey | en_US |
