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dc.contributor.authorGümüştaş, Mehmet
dc.contributor.authorCoşkun, Gökçe
dc.contributor.authorÖzkan, Sibel Ayşıl
dc.date.accessioned2019-05-10T09:39:15Z
dc.date.available2019-05-10T09:39:15Z
dc.date.issued2015
dc.identifier.citationGumustas, M., Coskun, G., & Ozkan, S. A. (2015). Selective and sensitive determination of repaglinide in pharmaceuticals by voltammetric and LC methods. Revue Roumaine de Chimie, 60(5), 477-490.en_US
dc.identifier.issn0035-3930
dc.identifier.urihttps://hdl.handle.net/11491/647
dc.description.abstractDetailed electrochemical study and novel voltammetric and LC methods are presented for the determination of repaglinide (RPG) in pharmaceuticals. Repaglinide in methanol: buffer solution (20:80; v/v) shows one or two anodic responses on glassy carbon electrode between pH 0.3 and 12.0 depending on the pH values. The HPLC and UPLC methods were developed using core shell columns with mobile phase consisting of 50:50; ACN:Water (0.05 % TFA; at pH: 3.0) (v/v) with UV detection at 215 nm. Finally, the proposed methods were successfully applied for the determination of RPG in pharmaceutical dosage forms. The proposed voltammetric and LC methods allow a number of cost and time saving benefits. RPG was also exposed to thermal, photolytic, oxidative stress, acid-base catalyzed hydrolyses, and the stressed samples were detected by the proposed RP-HPLC method.en_US
dc.language.isoeng
dc.publisherEditions de l'Academie Republique Populaireen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[Belirlenecek]en_US
dc.titleSelective and sensitive determination of repaglinide in pharmaceuticals by voltammetric and LC methodsen_US
dc.typeconferenceObjecten_US
dc.relation.journalRevue Roumaine de Chimieen_US
dc.departmentHitit Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümüen_US
dc.identifier.volume60en_US
dc.identifier.issue05.Junen_US
dc.identifier.startpage477en_US
dc.identifier.endpage490en_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US


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