Retrospective Analysis of Human Serum Albumin use From Gynecologic and Obstetric Point of View

Abstract

Aim: Human serum albumin (HSA) is the most abundant circulating protein in the body. HSA, as a colloid solution, used for several conditions in daily clinical practice especially in intensive care units. HSA is commonly used for several indications but its administration could often be considered as inappropriate. Gynecology and obstetrics is an important specialty that HAS administration is necessary for several different conditions. Beside the proportion of inappropriate use, the elevated cost, the theoretical risk of disease transmission and the existence of more economical alternatives of rationalize, we would like to emphasize the appropriate use of HSA in obstetrics and gynecology practice by the help of hospital's data, which is a tertiary care center in Turkey for Obsterics and gynecology practice. Material and Method: Retrospectively we investigate the percentage of human albumin use in term of sub departments such as perinatology, gynecological oncology and reproductive endocrinology. At the end of 2012 Ministry of health published a guideline for hospital to regulate the use of Human Albumin in medical practice. They mentioned the appropriate indications and alternative treatment methods for human Albumin use for the clinicians. The change in the HSA use indications and rate of HSA use per cases was statistically compared. Results: In 2012 Albumin use per birth in perinatology clinic is 0, 0027/birth, in 2013 it is dropped to 0, 0018/birth. The only department that HSA use increases after implementation of guideline is gynecologic oncology Discussion: There is a significant decrease in HSA use in clinics except gynecologic oncology in daily practice. Besides this decrease inappropriate use is still common. We believe that understanding the appropriate indications and common mistakes in daily practice could be useful for gynecologists to determine the definitive treatment of options in their services.