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dc.contributor.authorAslanoğlu, Furgan
dc.contributor.authorBaşçeken, Sinan
dc.contributor.authorBalcı, Metin
dc.date.accessioned2019-05-10T09:39:18Z
dc.date.available2019-05-10T09:39:18Z
dc.date.issued2019
dc.identifier.citationAslanoğlu, F., Basçeken, S., Balcı, M. (2019). Synthesis of pyrrolo-pyrrolo-pyrazines via the Pd/C-catalyzed cyclization of N-propargyl pyrrolinyl-pyrrole derivatives. Tetrahedron letters, 60(5), 449-451.en_US
dc.identifier.issn0040-4039
dc.identifier.urihttps://doi.org/10.1016/j.tetlet.2019.01.004
dc.identifier.urihttps://hdl.handle.net/11491/664
dc.description.abstractA novel and efficient synthesis of N-substituted dipyrrolo[1,2-a:2',1'-c]pyrazine derivatives has been developed. The synthetic strategy relies on the synthesisof 4',5'-dihydro-1H,3'H-2,2'-bipyrrole, followed by the reaction with propargyl bromide. Various substituents were introduced to the alkyne functionality using the Sonogashira coupling reaction. Aromatization of the dihydropyrrole ring followed by an intramolecular cyclization reaction between the alkyne functionality and the pyrrole nitrogen atom was catalyzed by Pd/C at high temperature to furnish the desired dipyrrolo-pyrazine skeleton. (C) 2019 Elsevier Ltd.en_US
dc.language.isoeng
dc.publisherElsevier Ltden_US
dc.relation.isversionof10.1016/j.tetlet.2019.01.004en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlkyne Cyclizationen_US
dc.subjectBipyrroleen_US
dc.subjectDipyrrolopyrazineen_US
dc.subjectPyrazineen_US
dc.subjectPyrroleen_US
dc.titleSynthesis of pyrrolo-pyrrolo-pyrazines via the Pd/C-catalyzed cyclization of N-propargyl pyrrolinyl-pyrrole derivativesen_US
dc.typearticleen_US
dc.relation.journalTetrahedron Lettersen_US
dc.departmentHitit Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümüen_US
dc.authorid0000-0002-6311-1918en_US
dc.identifier.volume60en_US
dc.identifier.issue5en_US
dc.identifier.startpage449en_US
dc.identifier.endpage451en_US
dc.relation.tubitakTBAG-112T360
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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