Clinicopathological findings of thirty-nine gastrointestinal neuroendocrine neoplasms

Abstract

Aim: In this study aimed to re-evaluate the clinicopathological parameters of gastrointestinal system neuroendocrine neoplasms (GIS-NENs) that have been diagnosed in our pathology department between 2008 and 2017, and to examine survival durations. Materials and Methods: The study included GIS-NENs samples of 39 patients. The total number of organ biopsies, the number of NENs, age, gender, localization, diameter, mitosis, necrosis, lymhovascular invasion and perineural invasion characteristics were evaluated. The association between survival and Ki-67 index was analysed. Results: We identified 39 cases of GIS-NENs that had developed from the appendix, stomach, rectum, cecum, ileum, and duodenum. Thirty four cases were diagnosed with G1 (87.2%), one case with G2 (2.6%), and four cases with G3 (10.3%). One patient was diagnosed with G3 and T2 and died during the 9th month under treatment. Another patient diagnosed with G3 and T1 died during the 26th month. Conclusion: In the diagnosis of GIS-NENs has increased in recent years because of the widespread use to endoscopy. While endoscopic and small diameter NENs are histologically evaluated, after all sections of the tumor tissue have been examined in the largest area, the Ki-67 index score and mitotic rate should be determined based on the WHO 2010 classification criteria. According to the Cox regression result, a unit increases in the Ki-6 7 index increases the probability of death by 3.1%.