Gelişmiş Arama

Basit öğe kaydını göster

dc.contributor.authorPektas, Gokhan
dc.contributor.authorPektas, Suzan Demir
dc.contributor.authorOztekin, Aynure
dc.contributor.authorOztekin, Coskun
dc.contributor.authorNeselioglu, Salim
dc.contributor.authorErel, Ozcan
dc.contributor.authorSadi, Gokhan
dc.date.accessioned2021-11-01T15:02:57Z
dc.date.available2021-11-01T15:02:57Z
dc.date.issued2019
dc.identifier.issn0354-4664
dc.identifier.issn1821-4339
dc.identifier.urihttps://doi.org/10.2298/ABS181003047P
dc.identifier.urihttps://hdl.handle.net/11491/6876
dc.description.abstractVitiligo is a multifactorial disorder commonly associated with hypo-/depigmentation in the skin and may influence both children and adults psychologically because of the notable leopard-skin-like appearance. This study was designed to investigate the thiol/disulfide homeostasis in patients with generalized vitiligo and to determine its relationship with some of the demographical characteristics. Seventy-six generalized vitiligo patients and 67 healthy individuals were included in the study. Blood serum native thiol, disulfide and total thiol concentrations, together with some hematological parameters, were determined. Results demonstrated that native and total thiol contents, and their ratios, were significantly lower in vitiligo patients. Disulfide/native thiol and disulfide/total thiol ratios were significantly higher in the patient group. Progressivity of the disease strongly regulated the thiol/disulfide homeostasis in such a way that active vitiligo patients had reduced native and total thiol levels but increased disulfide/native thiol and disulfide/total thiol ratios. Moreover, there was a statistically significant negative correlation between both duration of the vitiligo and native and total thiol contents. As these results clearly demonstrated that thiol/disulfide homeostasis was shifted toward disulfide formation in patients with generalized vitiligo, determining the dynamic nature of thiol/disulfide homeostasis can be used to monitor disease progression.en_US
dc.description.sponsorshipHitit University and Yildirim Beyazit Universityen_US
dc.description.sponsorshipThis study was supported partially by Hitit University and Yildirim Beyazit University which kindly provided laboratory reagents and equipment.en_US
dc.language.isoengen_US
dc.publisherInst Bioloska Istrazivanja Sinisa Stankovicen_US
dc.relation.ispartofArchives Of Biological Sciencesen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectgeneralized vitiligoen_US
dc.subjectnative thiolen_US
dc.subjectdisulfideen_US
dc.subjecttotal thiolen_US
dc.subjecthomeostasisen_US
dc.titleDynamic thiol/disulfide homeostasis in serum of patients with generalized vitiligoen_US
dc.typearticleen_US
dc.department[Belirlenecek]en_US
dc.authoridEREL, Ozcan / 0000-0002-2996-3236
dc.authoridSadi, Gokhan / 0000-0002-6422-1203
dc.identifier.volume71en_US
dc.identifier.issue1en_US
dc.identifier.startpage55en_US
dc.identifier.endpage62en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.department-temp[Pektas, Gokhan] Mugla Sitki Kocman Univ, Training & Res Hosp, Dept Hematol, TR-48000 Mugla, Turkey; [Pektas, Suzan Demir] Mugla Sitki Kocman Univ, Fac Med, Dept Dermatol, TR-48000 Mugla, Turkey; [Oztekin, Aynure] Hitit Univ, Fac Med, Dept Dermatol, TR-19000 Corum, Turkey; [Oztekin, Coskun] Hitit Univ, Fac Med, Dept Family Med, TR-19000 Corum, Turkey; [Neselioglu, Salim; Erel, Ozcan] Yildirim Beyazit Univ, Fac Med, Dept Biochem, TR-06800 Ankara, Turkey; [Sadi, Gokhan] Karamanoglu Mehmetbey Univ, KO Sci Fac, Dept Biol, TR-70100 Karaman, Turkeyen_US
dc.contributor.institutionauthor[Belirlenecek]
dc.identifier.doi10.2298/ABS181003047P
dc.authorwosidEREL, Ozcan / U-1008-2019
dc.authorwosidSadi, Gokhan / AAK-5468-2021
dc.description.wospublicationidWOS:000463592100007en_US
dc.description.scopuspublicationid2-s2.0-85065495508en_US


Bu öğenin dosyaları:

DosyalarBoyutBiçimGöster

Bu öğe ile ilişkili dosya yok.

Bu öğe aşağıdaki koleksiyon(lar)da görünmektedir.

Basit öğe kaydını göster