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dc.contributor.authorÖzbaş, Zehra
dc.contributor.authorÖzkahraman, Bengi
dc.contributor.authorBal Öztürk, Ayça
dc.date.accessioned2019-05-10T09:39:39Z
dc.date.available2019-05-10T09:39:39Z
dc.date.issued2018
dc.identifier.citationÖzbaş, Z., Özkahraman, B., & Öztürk, A. B. (2018). Controlled release profile of 5-fluorouracil loaded P (AAM-co-NVP-co-DEAEMA) microgel prepared via free radical precipitation polymerization. Polymer Bulletin, 75(7), 3053-3067.en_US
dc.identifier.issn0170-0839
dc.identifier.urihttps://doi.org/10.1007/s00289-017-2202-0
dc.identifier.urihttps://hdl.handle.net/11491/747
dc.description.abstractA new microgel was prepared by free radical precipitation polymerization of acrylamide (AAM), 1-vinyl-2-pyrrolidone (NVP) and 2-(diethylamino)ethyl methacrylate (DEAEMA) to be used for the controlled drug release. The zeta-potential and particle size of P(AAM-co-NVP-co-DEAEMA) microgel were measured by dynamic light scattering (DLS) measurements and found to be around ? 36.4 ± 6.29 mV and 592 nm, respectively. P(AAM-co-NVP-co-DEAEMA) microgel was loaded with 5-Fluorouracil (5-Fu) as a model drug. In vitro drug release profiles demonstrated that 5-Fu release from P(AAM-co-NVP-co-DEAEMA) microgel at pH 7.4 was much faster than at pH 5.5 and pH 2.1. In addition, release kinetic studies showed that P(AAM-co-NVP-co-DEAEMA) microgel fit into Higuchi model release. The cytotoxicity study indicated that P(AAM-co-NVP-co-DEAEMA) microgel did not exhibit apparent cytotoxicity against L929 cell line. When all of the results were evaluated, it can be seen that P(AAM-co-NVP-co-DEAEMA) microgel can be effectively used as a polymeric drug carrier for the potential drug delivery systems in medical applications. © 2017, Springer-Verlag GmbH Germany.en_US
dc.language.isoeng
dc.publisherSpringer Verlagen_US
dc.relation.isversionof10.1007/s00289-017-2202-0en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject2-(Diethylamino)ethyl Methacrylateen_US
dc.subject5-Fluorouracilen_US
dc.subjectControlled Releaseen_US
dc.subjectMicrogelen_US
dc.subjectPrecipitation Polymerizationen_US
dc.titleControlled release profile of 5-fluorouracil loaded P(AAM-co-NVP-co-DEAEMA) microgel prepared via free radical precipitation polymerizationen_US
dc.typearticleen_US
dc.relation.journalPolymer Bulletinen_US
dc.departmentHitit Üniversitesi, Mühendislik Fakültesi, Polimer Mühendisliği Bölümüen_US
dc.authorid0000-0003-1535-4381en_US
dc.identifier.volume75en_US
dc.identifier.issue7en_US
dc.identifier.startpage3053en_US
dc.identifier.endpage3067en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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