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dc.contributor.authorTecer, Duygu
dc.contributor.authorEker Büyükşireci, Dilek
dc.contributor.authorGünendi, Zafer
dc.contributor.authorGöğüş, Feride
dc.date.accessioned2021-11-01T18:14:53Z
dc.date.available2021-11-01T18:14:53Z
dc.date.issued2020
dc.identifier.citationTecer, D., Büyükşireci, D., Günendi, Z., & Göğüş, F. (2020). The association of serum beta-2-microglobulin with autoantibody production and disease activity in patients with primary Sjögren’s syndrome. Gülhane Tip Dergisi, 62(4), 272.en_US
dc.identifier.issn1302-0471
dc.identifier.issn2146-8052
dc.identifier.urihttps://doi.org10.4274/gulhane.galenos.2020.1070
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TkRJek1UZzJOZz09
dc.identifier.urihttps://hdl.handle.net/11491/7561
dc.description.abstractAims: The aim of the this study is to evaluate beta-2-microglobulin (B2M) levels in patients with primary Sjögren’s syndrome (pSS) and to investigate their correlation with serum biomarkers and disease activity indexes commonly used in daily clinical practice.Methods: Eighty-one patients with pSS were included in this retrospective and cross-sectional study. Demographic data, clinical characteristics, B2M, immunoglobulin (Ig) A, IgG, IgM, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), serum complement (C) 3 and C4 levels, anti-nuclear antibody, rheumatoid factor (RF), anti-SSA and anti-SSB antibodies were obtained from the medical records. Disease activity was evaluated by the European League Against Rheumatism (EULAR) SS Disease Activity Index (ESSDAI) and EULAR SS Patients Reported Index (ESSPRI). Results: Serum B2M level was significantly higher in patients with anti-SSA and anti-SSB antibody (median: 2.64 mg/dL, minimum: 2.02 mg/dL, maximum: 10.10 mg/dL) than in only anti-SSA positive patients (median: 2.31 mg/dL, minimum: 1.33 mg/dL, maximum: 4.26 mg/dL, p=0.010) and both antibody negative patients (median: 1.80 mg/dL, minimum: 1.20 mg/dL, maximum: 2.65 mg/dL, p<0.001). Also, patients with anti-SSA antibody have significantly higher serum B2M levels than anti-SSA and anti-SSB antibodies negative patients (p=0.009). Serum B2M level was significantly correlated with ESSDAI (r=0.482, p=0.001), serum IgG level (r=0.374, p=0.001), IgA level (r=0.341, p=0.002), RF levels (r=0.412, p=0.021) and ESR (r=0.239, p:0.031). There was no correlation between ESSPRI, IgM, CRP and serum B2M levels. ESSDAI was not correlated with C3 (r=0.044, p=0.697), C4 (r=-0.053, p=0.640), ESR (r=0.111, p=0.326), CRP (r=0.111, p=0.324) and IgG (r=0.154, p=0.169).Conclusions: Although serum B2M levels were higher in autoantibody positive patients, it has a weak correlation with clinical disease activity.en_US
dc.language.isoengen_US
dc.relation.ispartofGülhane Tıp Dergisien_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPrimary Sjögren’s Syndromeen_US
dc.subjectBeta-2-microglobulinen_US
dc.subjectESSDAIen_US
dc.subjectESSPRIen_US
dc.subjectBiomarkersen_US
dc.titleThe association of serum beta-2-microglobulin with autoantibody production and disease activity in patients with primary Sjögren’s syndromeen_US
dc.typearticleen_US
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.authoridTecer, Duygu / 0000-0002-8816-6181
dc.authoridEker Büyükşireci, Dilek / 0000-0002-5420-7563
dc.authoridGünendi, Zafer / 0000-0003-0696-5834
dc.authoridGöğüs, Feride / 0000-0003-0921-5991
dc.identifier.volume62en_US
dc.identifier.issue4en_US
dc.identifier.startpage272en_US
dc.identifier.endpage277en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.department-tempSağlık Bilimleri Üniversitesi Türkiye, Gülhane Eğitim ve Araştırma Hastanesi, Romatoloji Kliniği, Ankara, Türkiye;Hitit Üniversitesi, Erol Olçok Eğitim ve Araştırma Hastanesi, Fiziksel Tıp ve Rehabilitasyon Kliniği, Çorum, Türkiye;Gazi Üniversitesi Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, Romatoloji Anabilim Dalı, Ankara, Türkiye;Gazi Üniversitesi Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, Romatoloji Anabilim Dalı, Ankara, Türkiyeen_US
dc.contributor.institutionauthorEker Büyükşireci, Dilek
dc.identifier.doi10.4274/gulhane.galenos.2020.1070
dc.description.scopuspublicationid2-s2.0-85101230572en_US


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