Obesity is associated with upgrading in prostate cancers

Abstract

BACKGROUND: Prostate cancer (PCa) is the second most common cancer and sixth most common cause of cancer associated death among men in the world. Multiple studies demonstrated the relationship between obesity and PCa in the recent years.AIM: The present study aimed to investigate the impact of obesity on postoperative oncological results after radical prostatectomy.MATERIALS AND METHODS: A total of 110 patients who were treated radical prostatectomy between January 2011 and April 2016 were analyzed retrospectively. The patients who had information about age, height, weight, biopsy results, PSA level and pathological results were recorded. The patients were classified to three groups according to the BMI; normal (BMI<25 kg/m2), overweight (BMI>25 and <30 kg/m2) and obese (BMI>30 kg/m2).RESULTS: The present study included 101 patients. Of these patients; 26, 57 and 18 patients were in groups respectively. The age at the presentation and PSA level was lower and higher than the other patients. The proportion of locally advanced disease and high grade PCa were the highest in obese patients at prostatectomy specimen examination. The upgrading is significantly associated with obesity.CONCLUSION: This study demonstrated that obese men are younger and had higher PSA concentration at the diagnosis of PCa. High grade PCa, locally advanced disease and upgrading was seen much more in patients with BMI>30 kg/m2 at final pathology. The difference reached significance for upgrading between groups.