Obstruktif Uyku Apne Sendromu’nda Nötrofil Lenfosit Oranı

Abstract

Amaç: Nötrofil ve lenfosit oranı (NLO)’nın inflamatuar belirteç olarak inflamatuar hastalıklarda rolü keşfe- dilmiştir. Obstruktif uyku apne sendromu (OSAS)’da komorbiditeler ile OSAS’da artan NLO arasındaki ilişki değerlendirildi. Yöntem: Toplam 232 OSAS hastası çalışmaya alındı. 50 OSAS olmayan olgu kontrol grubunu oluşturdu. NLO her hasta ve kontrol olgusu için hesaplandı ve kaydedildi. Nötrofil lenfosit oranıyla hipertansiyon arasındaki ilişki hipertansiyonu olan ve olmayan iki alt hasta grubunda değerlendirildi. Bulgular: Çalışmada 100 kadın (%43.1), 132 erkek (%56.9) hasta mevcuttu. OSAS hastalarında ortalama NLO (1.76±0.77), kontrol grubunda ortalama NLO (1.31±0.74) ile karşılaştırıldığında anlamlı olarak daha yüksekti (p= 0.000). Hipertansiyon (HT) olan (3.59±14.92) ve olmayan (1.72±0.69) OSAS’lı hastalarda NLO’da anlamlı farklılık saptandı (p= 0.014). Sonuç: OSAS’da NLO inflamatuar belirteç olarak değerli olabilir. OSAS’da artan NLO, bu hastalardaki HT gibi komorbid durumlardan kaynaklanabilir. Bu ucuz ve pratik method, günlük klinik pratikte, OSAS hastalarında komorbiditeyi öngörmek için kullanılabilir.

Objective: The role of neutrophil to lymphocyte ratio as an inflammatory marker in inflammatory conditions has been explored. The association between neutrophil to lymphocyte ratio, which is elevated in patients with obstructive sleep apnea syndrome, and hypertension in obstructive sleep apnea syndrome has been examined. Methods: A total of 232 obstructive sleep apnea syndrome patients were included in this study. A total of 50 subjects without obstructive sleep apnea syndrome comprised the control group. The neutrophil to lymphocyte ratio was calculated and recorded for each patient and control subject. The association of neutrophil to lymphocyte ratio to hypertension was investigated in two sub-groups of patients defined on the basis of the presence or absence of hypertension. Results: There were 100 (43.1%) female and 132 (56.9%) male patients in the study. Obstructive sleep apnea syndrome patients had significantly higher average neutrophil to lymphocyte ratio (1.76 ± 0.77) as compared to controls (1.31 ± 0.74) (p=0.000). A significant difference in neutrophil to lymphocyte ratio between obstructive sleep apnea syndrome patients with (3.59 ± 14.92) or without (1.72 ± 0.69) hypertension was found (p=0.014). Conclusion: Neutrophil to lymphocyte ratio may find some value as an inflammatory marker in obstructive sleep apnea syndrome. Elevated neutrophil to lymphocyte ratio in obstructive sleep apnea syndrome may arise from comorbid conditions such as hypertension in these patients. This cheap and practical method may be used in daily clinical practice to predict comorbidity in OSAS patients.