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dc.contributor.authorŞentürk, Salim
dc.contributor.authorGürçay, Ahmet Gürhan
dc.contributor.authorBozkurt, İsmail
dc.contributor.authorGürcan, Oktay
dc.contributor.authorEroğlu, Hakan
dc.contributor.authorTürkoğlu, Ömer Faruk
dc.contributor.authorBodur, Ebru
dc.contributor.authorBavbek, Murat
dc.date.accessioned2019-05-10T09:39:54Z
dc.date.available2019-05-10T09:39:54Z
dc.date.issued2015
dc.identifier.citationŞentürk, S., Gürçay, A. G., Bozkurt, İ., GÜrcan, O., Eroğlu, H., Türkoğlu, O. F., Bodur, E., Bavbek, M. (2015). Effects of tadalafil—type-V phosphodiesterase enzyme inhibitor—on rats with spinal trauma. British Journal of Neurosurgery, 29(2), 254-259.en_US
dc.identifier.issn0268-8697
dc.identifier.urihttps://doi.org/10.3109/02688697.2014.976174
dc.identifier.urihttps://hdl.handle.net/11491/801
dc.description.abstractIn this research, the effect of tadalafil, a selective inhibitor of cyclic guanosine monophosphate-specific phosphodiesterase type 5, on rats with spinal trauma was evaluated. The evaluation consisted of neurological examination and biochemical parameters. Twenty healthy male Wistar albino rats were used in this study. They were separated into three groups: tadalafil-receiving (TD) group (n = 7), laminectomy and trauma (LT) group (n = 7), and just laminectomy group (n = 6). The TD group received daily dose of tadalafil (10 mg/kg) for a week along with bait and water. Each rat's spinal cord was dissected with utter caution. The spinal cord was traumatized by Allen's weight-drop method. Using a standard apparatus, 5 g of weight was dropped from a height of 10 cm on the spinal cords of the TD and LT (laminectomy + trauma) group. No extra maneuvers were conducted on the laminectomy group. A day later, the rat's functional neurological status was examined followed by re-exploration of the spinal cord for sampling 1 cm of tissue. The Tarlov scale was used to evaluate the functional neurological status. The modified Tarlov scale was rated to be significantly higher in the TD group than that in the LT group. For the biochemical parameters, malondialdehyde (MDA) and cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-? (TNF-?) involved in the inflammatory process were examined. MDA - an indicator of lipid peroxidation-was found to be significantly lower in the TD group compared with that in the LT group. TNF-? and IL-6 levels were also found to be lower in the TD group compared with those in the LT group. Shortly, this research showed that the use of TD group in spinal trauma resulted in better neurological outcome and significant improvement in biochemical parameters. © 2015 The Neurosurgical Foundation.en_US
dc.language.isoeng
dc.publisherInforma Healthcareen_US
dc.relation.isversionof10.3109/02688697.2014.976174en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNeuroprotectionen_US
dc.subjectSecondary Injuryen_US
dc.subjectSpinal Cord Injuryen_US
dc.subjectTadalafilen_US
dc.subjectTarlov Scaleen_US
dc.titleEffects of tadalafil - Type-V phosphodiesterase enzyme inhibitor - On rats with spinal traumaen_US
dc.typearticleen_US
dc.relation.journalBritish Journal of Neurosurgeryen_US
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.identifier.volume29en_US
dc.identifier.issue2en_US
dc.identifier.startpage254en_US
dc.identifier.endpage259en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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