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dc.contributor.authorArduç, Ayşe
dc.contributor.authorAyçiçek Doğan, Berçem
dc.contributor.authorTuna, Mazhar Müslüm
dc.contributor.authorAteş Tütüncü, Yasemin
dc.contributor.authorIşık, Serhat
dc.contributor.authorBerker, Dilek
dc.contributor.authorGüler, Serdar
dc.date.accessioned2019-05-10T09:40:07Z
dc.date.available2019-05-10T09:40:07Z
dc.date.issued2015
dc.identifier.citationArduç, A., Doğan, B., Tuna, M. M., Ateş Tütüncü, Y., Işık, S., Berker, D., Güler, S. (2015). Higher body mass index and larger waist circumference may be predictors of thyroid carcinoma in patients with Hürthle‐cell lesion/neoplasm fine‐needle aspiration diagnosis. Clinical Endocrinology, 83(3), 405-411.en_US
dc.identifier.issn0300-0664
dc.identifier.urihttps://doi.org/10.1111/cen.12628
dc.identifier.urihttps://hdl.handle.net/11491/845
dc.description.abstractObjective High body mass index (BMI) has been found to be associated with raised thyroid cancer risk, particularly in women. We examined the associations for BMI and waist circumference (WC) with thyroid cancer risk among women with Hürthle‐cell lesion/neoplasm (HLN) on fine‐needle aspiration biopsy (FNAB) with the hypothesis that BMI and WC could guide the management of these challenging indeterminate lesions. Methods This cross‐sectional study included 224 women with HLN who underwent thyroidectomy. In all patients, TSH and thyroid auto‐antibodies were evaluated, and thyroid nodule features were recorded. Patients were grouped according to BMI (<30 or ≥30 kg/m2) and WC (<88 or ≥88 cm). Relationships of thyroid cancer with BMI and WC were assessed using logistic regression analysis. Results Mean weight, BMI (31·26 ± 5·1 vs 26·47 ± 5·9, P < 0·001), WC (98·23 ± 7·6 vs 86·18 ± 11, P = 0·001), and proportion of patients with high BMI (≥30 kg/m2) (65·9 vs 33·8%, P < 0·001) or large WC (≥88 cm) (84·1 vs 47·9%, P < 0·001) were significantly higher in malignant group compared to benign group. In regression analysis, BMI and WC significantly associated with existence of malignancy. Malignancy risk was 3·819‐fold higher (95% CI: 2·068–7·054) in BMI≥30 kg/m2 group compared to BMI<30 kg/m2, which was independent of TSH and age. Large WC was also associated with increased risk (OR = 5·593, 95% CI: 2·736–11·434). Baseline tumour characteristics were similar according to BMI and WC groups. Conclusions A great BMI and large WC were associated with higher thyroid cancer risk in patients with FNAB diagnosis of HLN. Further studies are needed to use BMI or WC in the management of patients with HLN.en_US
dc.language.isoeng
dc.publisherBlackwell Publishing Ltden_US
dc.relation.isversionof10.1111/cen.12628en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[Belirlenecek]en_US
dc.titleHigher body mass index and larger waist circumference may be predictors of thyroid carcinoma in patients with Hürthle-cell lesion/neoplasm fine-needle aspiration diagnosisen_US
dc.typearticleen_US
dc.relation.journalClinical Endocrinologyen_US
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.identifier.volume83en_US
dc.identifier.issue3en_US
dc.identifier.startpage405en_US
dc.identifier.endpage411en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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