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dc.contributor.authorLütfioğlu,Müge
dc.contributor.authorSakallıoğlu, Umur
dc.contributor.authorEser Sakallıoğlu, Elif
dc.contributor.authorBarış, Sancar
dc.contributor.authorGürgör, Pınar
dc.date.accessioned2019-05-13T08:57:07Z
dc.date.available2019-05-13T08:57:07Z
dc.date.issued2012
dc.identifier.citationLütfioğlu, M., Sakallıoğlu, U., Sakallıoğlu, E. E., Barış, S., Gürgör, P. (2012). The impact of dietary induced hyperparathyroidism on healthy and diseased periodontia: an experimental study in rats. Journal of Clinical Periodontology, 39(3), 264-271.en_US
dc.identifier.issn0303-6979
dc.identifier.urihttps://doi.org/10.1111/j.1600-051X.2011.01814.x
dc.identifier.urihttps://hdl.handle.net/11491/856
dc.description.abstractBackground and Objective Nutrition may be a potential modifying factor in periodontal conditions. The present study investigated this phenomenon for dietary induced hyperparathyroidism (dHPT) by revealing the histopathological and histomorphometrical profiles of healthy and diseased periodontia in dHPT. Methods Dietary induced hyperparathyroidism was induced in 12 rats by dietary calcium/phosphorous imbalance and 12 rats were fed standard diet (SD). Periodontitis was induced on the right mandibular molar teeth (mmt) of these rats by injecting an endotoxin + saline solution whereas injecting pure saline to the left mmt. Thus, four study groups were created: dHPT + saline (group 1), dHPT + endotoxin (group 2), SD + endotoxin (group 3) and SD + saline (group 4). Histological sections were obtained from the second mmt and examined using light microscope. Results Group 1 demonstrated inflammatory and degenerative alterations in periodontium without pocket formation. Periodontitis was evident in groups 2 and 3. Group 2 revealed the highest amounts of gingival inflammatory cell and vessel counts (group 2 > group 3 > group 1 > group 4), attachment and bone losses (group 2 > group 3 > groups 1 > group 4) and osteoclast count (group 2 > group 3 > group 1 > group 4) (p < 0.05). Conclusion These results propose that dHPT may impair the health status of periodontium and may worsen the pathobiology of periodontal diseases. © 2011 John Wiley & Sons A/S.en_US
dc.language.isoeng
dc.relation.isversionof10.1111/j.1600-051X.2011.01814.xen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDietary Induced Hyperparathyroidismen_US
dc.subjectHost Modifying Factorsen_US
dc.subjectNutritionen_US
dc.subjectPeriodontal Diseaseen_US
dc.titleThe impact of dietary induced hyperparathyroidism on healthy and diseased periodontia: An experimental study in ratsen_US
dc.typearticleen_US
dc.relation.journalJournal of Clinical Periodontologyen_US
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.identifier.volume39en_US
dc.identifier.issue3en_US
dc.identifier.startpage264en_US
dc.identifier.endpage271en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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