Determination of dissociation constants of some antifungal drugs by two different methods at 298 K

Abstract

The dissociation constants of eight antifungal drugs (fenticonazole, isoconazole, itraconazole, ketoconazole, miconazole, ornidazole, tinidazole, tioconazole) have been determined in water and acetonitrile-water binary mixtures by two different methods. Different organic percentages of acetonitrile have been used. For the LC studies 62.5, 65.0 % and 70.0 (v/v) acetonitrile-water binary mixtures were used while spectroscopic measurements were done in water, 10.0 and 20.0 % (v/v) acetonitrile-water. The influence of acetonitrile on the dissociation constants was investigated. Graphical Abstract: [Figure not available: see fulltext.] © 2013 Springer Science+Business Media New York.