p(thyme oil) and p(clove oil) organo-particles with biocompatible, anticancer, antioxidant, and antibacterial properties against Capan-1 and L-929 cells

Abstract

The synthesis of p(ClO) and p(TO) organo-particles from clove oil and thyme oil is the first in the literature. The particles were tested against the L-929 cell line for cell viability/cytotoxicity. The anticancer activity was studied against the Capan-1 pancreatic cancer cell line. p(ClO) and p(TO) organo-particles were featured by thermogravimetry (TGA), Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), particle size (DLS), and particle charge (zeta potential, Zeta) analyses. Antioxidant, biocompatible, antimicrobial, and in vitro cytotoxicity specialties were investigated. p(ClO) and p(TO) organo-particles were found to be effective on the L-929 fibroblast cell line and Capan-1 pancreatic cancer cell line in research on Capan-1 and L-929 cell lines. Additionally, it was shown that large dosages of p(ClO) organo-particles were not hazardous to L-929 cell lines. A difference was found between the rates of cell viability and apoptosis and necrosis when the MTT study findings of p(ClO) and p(TO) organo-particles were studied in Capan-1 cell line. The p(TO) organo-particle had the highest % apoptosis rate. At the 100 g mL−1 concentration, the fibroblast cell viability of p(ClO) and p(TO) organo-particles was 176.46% and 107.78%, respectively. The IC50 value derived for the decrease in viability was determined as (2.22 mg mL−1) and it was calculated that it would kill the pancreatic cancer cells by 50% when doxorubicin and p(ClO) were administered combined.