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Öğe Analiz öncesi (preanalitik) hata kaynakları ve eğitimin hata önlemedeki rolü(Dicle Üniversitesi Tıp Fakültesi, 2012) Özcan, Oğuzhan; Güreser, Ayşe SemraAmaç: Bu çalışmada, biyokimya ve mikrobiyoloji laboratuarlarına gönderilen örneklerde preanalitik hataların analizi ve eğitimin hata önlemedeki rolü incelenmiştir. Gereç ve yöntem: Sekiz aylık dönem boyunca merkez laboratuarına kabul edilen tüm örnekler retrospektif olarak incelendi. Reddedilen örneklerin dağılımı, preanalitik hata kategorileri (yanlış örnek, uygunsuz tüp, hatalı barkod, fazla örnek, eksik örnek, pıhtılı örnek, hemolizli/ lipemik örnek, kontaminasyon ve diğer sebepler) ve çalışma gruplarına göre sınıflandırıldı. Laboratuar çalışma gruplarındaki hata tipi ve sıklığı örnek sayısına ve total hataya oranlanarak yüzde olarak gösterildi. Ayrıca kan ve idrar kültür örneklerindeki kontaminasyon sıklığı ve kontaminasyonun idrar kültürlerinde yaş ve cinsiyete göre dağılımı incelendi. Ayrıca, preanalitik süreçler hakkında verilen her eğitim öncesi ve eğitim sonrası dönemdeki hata oranları karşılaştırıldı. Bulgular: Preanalitik hata sıklığı % 0.77 olarak bulundu. En sık ilk üç hata nedeni sırasıyla, kontaminasyon (%30.4), pıhtılı örnek (%19.4) ve eksik örnek alımı (%15.6) olarak gözlendi. İdrar kültürlerindeki kontaminasyon yüzdesi (% 88.2) kan kültürlerinde gözlenenden (% 11.2) yüksekti. İdrar kültürlerinde en sık hata ise, kadın ve 18 yaş altı hastalarda gözlendi (sırasıyla %59 ve %88.6). Eğitimden sonraki aylarda hata oranları düşük olarak bulundu. Bu düşüş istatistiksel olarak anlamlı idi (p< 0.05). Sonuç: Laboratuar iş akışı içerisinde preanalitik hataların azaltılabilmesi için laboratuar ve kan alma personelinin sürekli eğitimi sağlanmalıdır.Öğe Correlation of serum galectin-3 level with renal volume and function in adult polycystic kidney disease(Springer Netherlands, 2019) Özkurt, Sultan; Doğan, İbrahim; Özcan, Oğuzhan; Fidan, Nurdan; Bozacı, İlter; Yılmaz, Behice; Bilgin, MuzafferPurpose: The decrease in kidney functions in autosomal dominant polycystic kidney disease (ADPKD) is strongly correlated with the severity and growth of kidney cysts. Total kidney volume (TKV) was shown to be an early marker of the severity of the disease and a predictor of reduction in kidney functions. New treatment approaches for ADPKD have led to a need for easily applicable strong biomarkers predicting progression of the disease. The profibrotic mediator of galectin-3 (Gal-3) is linked to development of renal fibrosis. Methods: The study included 74 patients with ADPKD diagnosis and 40 healthy controls. The TKV of patients was calculated using the manual tracing method on MR images. The serum Gal-3 levels of patient and healthy control groups were measured with the ELISA method. The correlations between serum Gal-3 value with TKV and kidney function were assessed in patients. Results: As the stage of chronic kidney disease (CKD) increased, serum Gal-3 and TKV values increased (p < 0.001, p = 0.049, respectively). Correlation analysis found a negative relationship between serum Gal-3 levels and eGFR (r: ? 0.515, p < 0.001); however, there was no relationship between serum Gal-3 and TKV (r = 0.112, p = 0.344). Linear regression analysis showed the major parameter affecting Gal-3 was eGFR (p = 0.016). Conclusions: In our study, we showed that renal impairment is an important determinant of Gal-3, and there is no correlation of Gal-3 and TKV in ADPKD. As a result, there is an urgent clinical need for new biomarkers to identify individuals with the chance of treatment in the early stage among ADPKD patients. © 2019, Springer Nature B.V.Öğe Çorum’da kistik ekinokokkoz ön tanısı ile başvuran hastaların radyolojik, biyokimyasal ve serolojik analizlerinin değerlendirilmesi(Ankara Mikrobiyoloji Derneği, 2015) Güreser, Ayşe Semra; Özcan, Oğuzhan; Özünel, Leyla; Boyacıoğlu, Zehra İlkay; Taylan Özkan, Hikmet AyşegülKistik ekinokokkoz (KE), Echinococcus granulosus’un neden olduğu bir zoonozdur. Klinik bulgularla hastalığın tanısını koymak zor olduğundan, ek olarak radyolojik ve serolojik yöntemlerin kullanılması gerekmektedir. Bu retrospektif çalışmada, KE ön tanısı konulan hastaların biyokimya, hemogram, serolojik ve radyolojik bulgularının değerlendirilmesi ve epidemiyolojik verilerin incelenerek bölgemizdeki durumun belirlenmesi amaçlanmıştır. Çalışmaya, Ekim 2009-Temmuz 2013 tarihleri arasında Hitit Üniversitesi Çorum Eğitim ve Araştırma Hastanesi Mikrobiyoloji Laboratuvarına KE ön tanısı ile çeşitli kliniklerden gönderilen 148’i kadın 105’i erkek olmak üzere toplam 253 hasta dahil edilmiştir. Hastaların serumları, Türkiye Halk Sağlığı Kurumu Mikrobiyoloji Referans Laboratuvarları Daire Başkanlığı’nca indirekt hemaglütinasyon (IHA) yöntemiyle çalışılmış, 1/160 ve üzeri titreler pozitif olarak kabul edilmiştir. Çalışmamızda, kadın olguların 23’ü (%15.5) ve erkek olguların dokuzunda (%8.6) olmak üzere toplam 32 (%12.7) hasta seropozitif olarak saptanmış, ancak cinsiyet açısından istatistiksel olarak anlamlı bir fark bulunamamıştır (X2= 2.72). Seropozitif hastaların yaş aralığı 16-90 yıl (ortalama: 51) olup, 24’ünün (%75) 40 yaş üstü grupta olması istatistiksel olarak anlamlı bulunmuştur (X2= 22.45). Seropozitif hastaların tümünde, ultrasonografi ve bilgisayarlı tomografi ile radyolojik bulgular tespit edilmiştir. Ayrıca, IHA testi negatif olmasına karşın, biri kadın biri erkek olmak üzere iki hastanın KE operasyonu geçirdiği ve patolojik olarak tanılarının doğrulandığı görülmüştür. Hastaların %43.8’inin genel cerrahi kliniğine başvurduğu, bunu enfeksiyon hastalıkları (%21.9), gastroenteroloji (%21.9) ve diğer (%12.5) kliniklerin izlediği belirlenmiştir. Seropozitif hastalarının 31 (%96.9)’inde radyolojik olarak karaciğer tutulumu saptanmış; bu hastaların ikisinde (%6.3) aynı zamanda akciğer tutulumu olduğu belirlenmiş, bir hastada (%3.1) ise karaciğer tutulumu olmadan sadece intraperitoneal tutulum rapor edilmiştir. Her ne kadar seropozitif hastaların %50’si (16/32) Çorum ili merkezinde ikamet ediyor olsa da, bu hastaların tarım ve hayvancılıkla uğraştıkları anlaşılmıştır. Biyokimyasal olarak tanı anında en sık yükselen test GGT (%28) olup, bunu ALT (%16), AST (%16) ve ALP (%13) artışı izlemiştir. Diğer biyokimyasal parametreler normal olarak değerlendirilmiştir. Hemogram parametrelerinde RDW yüksekliği (%29) en sık rastlanılan bulgu olup, bunu hematokrit (%23), hemoglobin (%19) ve MCV (%19) düşüklüğü takip etmiştir. Eozinofi li ise olguların %19’unda gözlenmiştir. Sonuç olarak, bölgemiz için halen önemli bir halk sağlığı problemi olan KE’un klinik bulgularının diğer sistem patolojileri ile karışabilmesi nedeniyle, tanıda klinik, radyolojik, serolojik ve biyokimyasal bulguların birlikte değerlendirilmesi yararlı olacaktır.Öğe Hyperemesis gravidarum affects maternal sanity, thyroid hormones and fetal health: a prospective case control study(Springer Verlag, 2015) Büyükkayacı Duman, Nuriye; Özcan, Oğuzhan; Bostancı, Mehmet ÖmerPurpose: Hyperemesis gravidarum (HG) is a condition of severe nausea or vomiting accompanied by various complications during pregnancy. In the present study, we aimed to demonstrate the effects of HG on mother and fetus health. Methods: Control and case group were arranged from 50 healthy pregnant women and 50 pregnant women with HG. Information about the participant women was gathered with data collection form and Beck’s Depression Inventory (BDI) and State Anxiety Inventory (SAI) were administered to the women. Following an abortion or delivery, the data about birth complications and neonatal health were collected. All laboratory results (blood count, thyroid hormones, electrolyte values and biochemical parameters) were gathered from the laboratory information system used in the hospital. Results: It was found that in the case group, mean postpartum weight, serum hemoglobin, hematocrit and thyroid stimulant hormone levels were lower than control group (p < 0.01). Conversely, case group women have higher T3 and T4 levels than control group (p < 0.01). There was no significant difference between the two groups in terms of intrauterine growth retardation, low birth weight and abortion but it was observed that women with HG had often delivered prematurely. The mean scores of BDI and SAI in the case group were higher than those of control group. Conclusion: These results suggested that HG may have adverse effects on both mother and baby’s health. Pregnant women with HG should be provided with training and consultancy services and be closely monitored in terms of anemia and thyroid hormones. © 2015, Springer-Verlag Berlin Heidelberg.Öğe Investigation of mindin levels in hypertensive patients with left ventricular hypertrophy and QRS fragmentation on electrocardiography(Taylor and Francis Ltd., 2018) Doğan, Tolga; Yetim, Mücahit; Çelik, Oğuzhan; Kalçık, Macit; Özcan, Oğuzhan; Doğan, İbrahim; Erenler, Ali Kemal; Bekar, Lütfü; Karavelioğlu, YusufPurpose: Mindin was associated with diabetic nephropathy, podocyte injury, colitis, allergic asthma, liver ischaemia and reperpusion injury and ischaemic brain injury. On the other hand, it was reported as a protective factor against obesity, cardiac hypertrophy, fibrosis and remodelling. Fragmented QRS complexes (fQRS) are markers of altered ventricular depolarisation owing to a prior myocardial scar and fibrosis. In this study, we aimed to investigate mindin levels in hypertensive patients with left ventricular hypertrophy and fQRS on electrocardiography. Methods: This observational case-control study enrolled 70 (36 female) hypertensive patients with fQRS and 38 (23 female) hypertensive control patients. All patients were evaluated by transthoracic echocardiography. Mindin levels were measured by the enzyme-linked immunosorbent assay (ELISA). Clinical, echocardiographic and laboratory data were compared between patient and control groups. Results: There was no significant difference between patient and control groups in terms of clinical, echocardiographic and routine laboratory parameters. The mindin levels were significantly higher in the patient group than controls (11.3 (7.21–19.31) vs 4.15 (2.86–6.34); p <.001). Multiple logistic regression analyses defined increased mindin levels as an independent predictor for the presence of fQRS (Odds ratio: 1.733; p =.034). Mindin levels >6.74 predicted the presence of fQRS with a sensitifity of 84.3% and specificity of 79.9% on receiver operating characteristic (ROC) curve analysis (The area under the curve:0.889; Confidence Interval: 0.827–0.951; p <.001). Conclusion: Mindin expressin is upregulated in hypertensive patients with fQRS complexes. In contrary to previous studies, increased mindin levels may be associated with myocardial fibrosis. © 2017, © 2017 Belgian Society of Cardiology.Öğe Is oxidative stress associated with total kidney volume in patients with autosomal dominant polycystic kidney disease?(Oxford Univ Press, 2020) Doğan, İbrahim; Eser, Barış; Aydemir, Nihal; Kayadibi, Hüseyin; Özcan, Oğuzhan; Fidan, Nurdan; Özkurt, SultanBackground and Aims : Ischemia Modified Albumin (IMA) is a marker of cardiovascular risk factor associated with oxidative stress. In this study, our aim was to determine oxidative stress status in autosomal dominant polycystic kidney disease (ADPKD) and to evaluate its relationship with total renal volume.Öğe Painful and painless shoulder Magnetic Resonance Imaging comparisons in hemodialysis patients and correlation with clinical findings(IOS Press, 2017) Çağlıyan Türk, Ayla; Fidan, Nurdan; Özcan, Oğuzhan; Özdemir, Ferda; Tomak, Leman; Özkurt, Sultan; Şahin, FüsunBACKGROUND: Shoulder pain is frequently observed in haemodialysis patients. OBJECTIVE: To compare haemodialysis patients with or without shoulder pain in terms of shoulder motion ranges, ?2 microglobulin levels and magnetic resonance imaging findings. METHODS: Forty-three patients undergoing dialysis were enrolled, of which 23 patients had explicit shoulder pain at night, which appeared during dialysis. Range of joint motion was evaluated. ?2 microglobulin value was recorded. MRI was used to evaluate rotator cuff tendons for thickness, homogeneity, integrity and presence of effusion. RESULTS: Ranges of motion were significantly lower in the painful shoulder group. Supraspinatus tendon thickness and the number of areas with effusion were higher in the painful group. There was a positive correlation between the ?2 microglobulin level and supraspinatus (r:0.352 p <0.05) and subscapular (r:0.454 p <0.05) tendon thicknesses. While effusion areas and pain (r:0.351 p < 0.05) showed positive correlation, there was a negative correlation between pain and shoulder motion ranges. CONCLUSIONS: Shoulder pain in dialysis patients can be related with tendon thickness and effusion.While the ?2 microglobulin level affects tendon thickness, it has no relation to pain and movement constraint. © 2017 - IOS Press and the authors.Öğe The effect of aerobic and high-intensity interval training on plasma pentraxin 3 and lipid parameters in overweight and obese women(PEERJ INC, 2024) Çiçek, Güner; Özcan, Oğuzhan; Akyol, Pelin; Işık, Özkan; Novak, Dario; Küçük, HamzaBackground. It is unclear whether different exercise programs lead to an increase in the concentration of plasma Pentraxin3 (PTX3), an anti-inflammatory protein. This study aimed to investigate the effects of aerobic exercise (AE) and high-intensity interval training (HIIT) on plasma PTX3 levels in overweight and obese women. Method. A total of 45 sedentary women aged between 32.26 ± 6.30 voluntarily participated in the study. The control group (CG, n = 15) was selected among normalweight women. Women in the group of participants who partook in exercise consisted of overweight and obese women according to a random method, including the AE group (n = 15) and the HIIT group (n = 15). The AE session conducted was 50 min in duration and consisted of warm-up exercises (5 min), and primary exercises (40 min, basic aerobic-step exercises). HIIT consists of warm-up exercises (5 min), primary exercises (work intervals: 6?10 × 1 min (80–90% HRmax), rest intervals: 1 min (walk, 50% HRmax), 21–29 min running. The exercises were applied for three sessions/week for 12 weeks. Fasting blood samples were taken from all participants before and after exercise and their body composition was measured. Results. As a result of two different 12-week exercises, serum PTX3 levels increased significantly by 47.53% in the AE group and 50.21% in the HIIT group (p < 0.01). It was determined that the mean PTX3 before and after exercise increased from 1.71 ± 0.43 to 2.47 ± 0.40 ng/dL and HIIT from 1.62 ± 0.39 to 2.31 ± 0.33 ng/dL. A significant decrease in body mass index (BMI) values were detected, approximately 5.81% in the AE group and 5.06% in the HIIT group (p < .01). A significant decrease was detected in glucose, insulin, HOMA-IR, LDL-C, and hsCRP whereas HDL-C and VO2max value increased significantly in both exercise groups (p < .05; p < .01). There were no significant differences in TG and TC levels between groups (p > .05). Also, no significant differences were found between the two types of exercises in terms of parameters. A significant negative correlation in the total sample was found between PTX3 with BMI, fat mass, LDL-C, and hsCRP.Öğe The effect of exercises on left ventricular systolic and diastolic heart function in sedentary women: Step-aerobic vs core exercises(Elsevier (Singapore) Pte Ltd, 2017) Çiçek, Güner; İmamoğlu, Osman; Güllü, Abdullah; Çelik, Oğuzhan; Özcan, Oğuzhan; Güllü, Esin; Yamaner, FarukThe purpose of this study is to investigate the effect of 16 weeks step-aerobic exercises and core exercises on left ventricular structure and function with some physiological parameters in sedentary women. Methods To achieve the purpose of this study, a total of 45 volunteers including (step-aerobic group (SAG, n = 25), core exercise group (CEG, n = 20) were selected as participants. Two different exercises were applied for 4 days a week, throughout 16 weeks, within 60 minutes for each exercise with the intensity of heart rate (HR) 60-70 percent. The HR was measured using a heart rate monitor for each subject. The physical, biochemical and echocardiographic characteristics of the women were measured before and after the exercise. Results During the exercise periods, there were a meaningful decrease in the body weight, BMI, value of waist region and hip circumference of the women in both intervention groups as well as in the values of HR, DBP, SBP (p < 0,05). In addition, serum homocysteine (Hcy) and high-sensitivity C-reactive protein (Hs-CRP) levels decreased and the VO2max and left ventricular diastolic end-diastolic dimension increased in both SAG and CEG (p < 0.05). The left ventricular diastolic functions of the SAG improved more than CEG. Left ventricular systolic ejection time and fractional shortening meaningfully improved in both SAG and CEG (p < 0.01). Conclusion 16 weeks of step-aerobic and core exercise showed significant changes of inflammatory and lipid markers with cardiac dimensions and had favorable effects on both left ventricular systolic function. Left ventricular diastolic function had more improved in SAG than the CEG. © 2017Öğe The effects of two different exercise programmes on adipose tissue hormones in sedentary middle-aged women(Informa Healthcare, 2015) Özcan, Oğuzhan; Bostancı, Mehmet Ömer; Çiçek, Güner; Yamaner, FarukAdipokines play an important role in obesity and related inflammatory disorders. We aimed to determine the effects of exercise training on serum adipokines. Forty sedentary women were randomly assigned to two groups as aerobic (AE) and core exercise (CE). The exercise programmes were performed 4 days a week for 16 weeks. Blood samples were taken before and after the 8 and 16 weeks training period. Percent changes of each parameter were calculated. Sixteen weeks of exercise caused significant decrease in body weight and fat mass (p<0.001), significant increase in adiponectin (16.1% in AE, 15.8% in CE group, p<0.05) and resistin levels (21.1% in AE and 26.6% in CE group, p<0.05) but had no effect on leptin and ghrelin levels. Eight weeks of exercise had no effect on adipokines except leptin. These data suggest that both exercise programmes have improving effects on body composition, adiponectin and resistin levels. © 2015 Informa UK Ltd. All rights reserved: reproduction in whole or part not permitted.Öğe The Oxidative Stress At Lungs After Menopause And The Antioxidant Effects Of Vitamin D, Fish Oil And Exercise in An Experimental Rat Model(Parlar Scientific Publications (P S P), 2020) Arslan, Sertaç; Arslan, Emine; Güney, Güven; Özcan, Oğuzhan; Demir, Emre; Uyar Hazar, Hale; Demirci, BuketMenopause is the permanent cessation of ovarian follicular activity and the menstrual cycle. There is little physiologic and histologic data concerning the possible effects of menopause on respiratory tract and possible beneficial agents for respiratory tract against the effects of menopause. The rat lungs and trachea have been obtainedfrom young and old rats which were treated with either vitamin D (VitD; 1000IU/kg/week),Fish oil (FO; 0.8 mL/kg/week) or exercise (running 45 minutes/3 times/week) for 12 weeks after one week overiectomy (OVX) followup. Oxidative stress markers found increased at OVX and OVX+E groups. However, oxidative stress marker levels were lower at OVX+E group than OVX group. Vitamin D and fish oil also caused decreased oxidative stress at lung tissue compared to OVX group. OVX group had histological changes such as epithelial desquamation, peribronchial smooth muscle hypertrophy, peribronchial lymphoid follicles, Type 2 pneumocyte hyperplasia; however, none of them was found at exercise group. Ovariectomy caused respiratory system effects in rats. Menopause cause oxidative stress; however, exercise, vitamin D and fish oil have protective effects against oxidative stress at lungs at different quantities. Ovariectomy group has the greatest damage compared to other groups. Exercise is the best protective modality against the effects of menopause at respiratory system.
