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Öğe Attitudes Towards Sun Protection And Skin Cancer Among Faculty Members And Students Of Medicine And Of Arts/Sciences At A Turkish University(2020) Oztekin, Coskun; Öztekin, Aynure; Şenel, EnginObjectives: Public knowledge about and attitude towards sun protection practices are important factors in attempts to avoid skin cancer and other harmful effects of sun exposure. Such are the awareness levels of the students of medicine or their educators as they deliver the information to the general public and shape public health policies. The aim of this study was to reveal the knowledge and attitudes of the faculty members and students of medicine and of arts/sciences at a Turkish university towards the effects of sun exposure and protection. Materials and Methods: This descriptive cross-sectional study was conducted by administering a 37-item questionnaire to students and faculty members in the School of Arts/Sciences, School of Medicine, and Vocational School of Medical Sciences at Hitit University. The questions were formulated to evaluate the participants’ level of knowledge regarding the effects of sun exposure and protection, the source of their knowledge about these subjects, and their behaviors related to environmental factors. Responses were subjected to statistical analyses with appropriate tools and methods. Results: The study included a total of 217 participants with an average age of 26.0 ± 9.2 years: 145 (66.8%) students and 72 (33.2%) faculty members. Of these, 118 (55.1%) were female and 151 (69.6%) were in medical fields. A great majority of the participants (n=204, 94%) had used sunscreens, and sunscreens with SPF>30 were the most commonly used ones (%44). Brand (45.2%) and high SPF (46.2%) were the most frequently considered aspects when buying sunscreens. A comparison of subgroups of participants based on gender, position, and area of study indicated some differences in knowledge and practices related to sun exposure and sun protection. Conclusion: Although students and faculty members of medical areas had generally higher level of knowledge about the issues surrounding sun exposure and protection in comparison with those from non-medical backgrounds, there is still a significant knowledge deficit about the severity of associated risks and some room for improvement even among the students and faculty members of medical schools. The methods and media channels that would be used to increase public awareness should be adapted according to the demographic characteristics of target audiences. Further studies with a more comprehensive and well-managed data collection tools and a larger sample from more diverse set of institutions are warranted to determine the overall picture in the target population of this study.Öğe Clinical Findings of Vitiligo Patients Attending a University Hospital Dermatology Clinic in Turkey(2020) Öztekin, AynureVitiligo is a common disorder which affects about 1% of the world population. The aim of this study was to evaluate the epidemiological data, comorbid diseases, and several blood parameters of the vitiligo patients. This study was performed as a retrospective chart review. Patient records were screened from the electronic database of the hospital. Descriptive statistics were given as mean ± standard deviation or median and interquartile ranges according to the distribution of the data. Categorical variables were summarized as number and percentage. Statistical analyses were performed with Jamovi program and p<0.05 was accepted as significance level (p value) in statistical analyses. This study included 68 individuals, 30 (44.1%) of whom were males, and 38 (55.9%) of whom were females. Comorbid diseases were detected in 22 (32.4%) patients. Thyroid diseases were present in 15 (22.1%) patients, and thyroid autoantibodies were positive in 12 (17.6%) patients. Exacerbations of disease were more frequent in females (p=0.025), and history of stress was also more frequent in females (p=0.011). History of stress related exacerbations were more frequent in females and patients older than 18 years of age. Therefore, it is important to evaluate psychological factors especially in women with vitiligo and to consult to a psychiatrist when necessary.Öğe Çorum'da göğüs hastalıkları ve dermatoloji kliniklerinde solunum alerjenlerine yönelik deri prick testi sonuçları: 2 yıllık retrospektif çalışma(Hitit Üniversitesi, 2019) Arslan, Sertaç; Şenel, Engin; Öztekin, Aynure; Gülhan, Meral; Koşar, Nezahat; Taylan Özkan, Hikmet AyşegülAmaç: Bölgemizde en sık karşılaşılan alerjenleri belirlemek, erken tanıya ve koruyucu tedbirlere katkıda bulunmak. Gereç ve Yöntem: Hitit Üniversitesi Tıp Fakültesi Eğitim Araştırma Hastanesi, erişkin Göğüs Hastalıkları ve Cildiye Polikliniklerine 1 Ocak 2016 ile 30 Nisan 2018 tarihleri arasında alerjik yakınmalarla başvuran ve alerji deri testi (prick) yapılan 179 hasta retrospektif olarak değerlendirildi. Bulgular: Hastaların yaş ortalaması 31,4 ± 17,6 idi. Hastaların 70 (%39,1)'inde alerjik kontakt dermatit, 29 (%16,2)'sinde astım, 24 (%13,4)'ünde alerjik rinit mevcuttu. Erkek ve kadın hastalar arasında solunum alerjen duyarlılığı açısından fark saptanmadı. Solunum alerjeni pozitif bulunan hastaların 54 (%30,2)'sinde ev tozu akarı alerjisi, 28 hastada (%15,6) köpek tüyüne karşı alerji, 24 hastada (%13,4) hamam böceği alerjisi saptandı. Sonuç: Alerjik şikayetlerle cildiye ve göğüs hastalıkları kliniklerine başvuran hastalarda en çok ev tozu akarlarına karşı alerjik duyarlılık saptandı. Akar duyarlılığı çayır polenleri, hamamböceği ve köpek tüyü duyarlılığı ile birlikte anlamlı olarak yüksek oranlarda saptandı.Öğe Diclofenac sodium Induced Nicolau Syndrome(Gazi Univ, Fac Med, 2020) Şenel, Engin; Öztekin, Aynure; Muslu, ÜmranNicolau syndrome (NS) also known as livedo-like dermatitis, is an uncommon but important cutaneous drug reaction. It was first described in 1924 and since then many patients have been reported in the literature. The disorder is characterized by intense pain in the injection site and followed by a livedoid reticular patch or indurated plaque. In some patients, this condition may progress into extensive necrosis of the skin and ulceration as seen in our patient. Herein we presented a 52-year-old man and presented with a painful, large ulcer on his left buttock after intramuscular diclofenac sodium administration and diagnosed with NS to draw attention of physicians to this rare and preventable condition.Öğe Images Download Cite Share Favorites Permissions Research Article: Observational Study The evolution of Pemphigus publications: A bibliometric analysis with research trends and global productivity(LIPPINCOTT WILLIAMS & WILKINS, 2024) Öztekin, Aynure; Öztekin, CoşkunDespite an increase in global research on the subject of Pemphigus, which seriously affects patient health and quality of life, there is no bibliometric research on this subject in literature to date. The aim of this study was to conduct a holistic analysis of scientific articles published on Pemphigus, using bibliometric methods. Articles published on the subject of Pemphigus between 1980 and 2021 were downloaded from the web of science (WoS) database and analyzed using various statistical methods. To determine trend subjects, collaboration between countries, and the most effective studies with citation analyses, visual network maps were obtained with bibliometric analyses. A total of 3034 articles were analyzed. The 3 countries making the greatest contribution to literature were the USA (n:831, 27.3%), Japan (n:402, 13.2%), and Germany (n:221, 7.2%). The 3 most active institutions were Keio University (n:163, 5.3%), Kurume University (n:130, 4.2%) and Tel Aviv University (n:107, 3.5%). The 3 journals publishing the most articles were the British Journal of Dermatology (n: 88), Journal of the American Academy of Dermatology (n:171) and the Journal of Investigative Dermatology (n:143). The 3 leading journals according to the mean number of citations (NC) per article (citation count: CC) were the New England Journal of Medicine (CC:246), the Lancet (CC:143) and the Journal of Cell Biology (CC:133). The author with the most articles published was Hashimoto Takashi (n.168, 5.5%). As a result of cluster analysis, it was seen that 9 different main clusters had been studied on Pemphigus subjects to date (1: desmoglein, 2: paraneoplastic Pemphigus (PNP) – Pemphigus types-desmosome, 3: desmoglein 1 ve 3-autoimmunity, 4: treatment-rituximab, 5: acantholysis-apoptosis, 6: quality of life-remission-relapse, 7: autoantibodies, 8: epidemiology-mortality, 9: corticosteroids). The most commonly studied subjects were determined to be pemphigus vulgaris (PV), pemphigus foliaceus (PF), autoimmunity, rituximab, PNP, desmoglein (desmoglein3-desmoglein1), autoantibodies, acantholysis, autoantibody, treatment, autoimmune disease, desmosome, ELISA, and immunofluorescence. The primary trending topic was rituximab drug, which is used in the treatment of Pemphigus. The other most studied trend topics were azathioprine drug used in treatment, intravenous immunoglobulin treatment, quality of life, mortality rates, Pemphigus herpetiformis, and wound healing. Abbreviations: AC = average citation per article, CC = citation count, CI = confidence interval, GDP = gross domestic product, HDI = human development index, NC = number of citations, PF = pemphigus foliaceus, PNP = paraneoplastic Pemphigus, PV = pemphigus vulgaris, UK = United Kingdom, USA = United States of America, WoS = web of science.Öğe Is There a Correlation Between Behcet Disease and Lower Urinary Tract Symptoms?(Korean Continence Soc, 2020) Başer, Aykut; Zümrütbaş, Ali Ersin; Özlülerden, Yusuf; Alkış, Okan; Öztekin, Aynure; Celen, Sinan; Aybek, ZaferPurpose: In this study, we aimed to determine the prevalence of lower urinary tract symptoms (LUIS) in patients with Behcet disease (BD) and to investigate the relationship between the severity of BD and LUIS. Methods: Fifty-five patients with BD were included in this study from January to December 2018. All patients received a detailed urological evaluation. Additionally, BD activity was investigated using the Behget Disease Current Activation Form. the International Prostate Symptom Score (IPSS), International Consultation on Incontinence Questionnaire Short Form, 8-item overactive bladder questionnaire forms, uroflowmetry, and postvoid residual urine volume were evaluated. Results: The mean age of the patients was 42.6 years. The mean activity score of BD was 4.6 +/- 3.2 and the mean IPSS score was 7.3 +/- 7.3. Sex had no significant effect on the BD activity score. the BD activity score was significantly correlated with the IPSS score, frequency of daytime urination, nocturia, and urgency. It was also correlated with the presence and the severity of urinary incontinence and the effect of urinary incontinence on daily life. Peak flow rate, voided volume, and the postvoid residual urine volume were not correlated with the BD activity score. Conclusions: LUTS were highly prevalent in patients with BD, and the severity and current activity of BD were correlated with frequency, nocturia, urgency, and urinary incontinence. Therefore, a urological evaluation of patients with BD in whom the activity and severity of the disease is elevated should be carried out comprehensively and patients should be managed accordingly.Öğe Is There a Correlation Between Behcet' s Disease and Lower Urinary Tract Symptoms?(Wiley, 2019) Başer, Aykut; Zümrütbaş, Ali Ersin; Özlülerden, Yusuf; Alkış, Okan; Öztekin, Aynure; Celen, Sinan; Aybek, ZaferBehcet’s disease (BD) is a chronic multisystemic inflammato-ry disorder of unknown etiology. The most common mani-festation of BD is oral aphthous ulcers (1,2,3). Other symp-toms of BD include mucous membrane involvement such as genital ulcers, eye and skin lesions, gastrointestinal, cardiac, vascular, neurologic and pulmonary system involvements. Genitourinary tract involvement is encountered not only with genital aphthous ulcers but also with the urological problems such as epididymitis and sterile urethritis (4).Öğe Ischemia-modified albumin as a possible marker of oxidative stress in patients with telogen effluvium(Elsevier Science Inc, 2020) Savcı, Ünsal; Şenel, Engin; Öztekin, Aynure; Sungur, Mustafa; Erel, Özcan; Neşelioğlu, SalimBackground: Telogen effluvium is the most common form of non-scarring alopecia characterized by diffuse hair loss. Ischemia-modified albumin is a marker of oxidative stress and inflammation. Objective: The aim of this study was to compare the levels of ischemia-modified albumin of telogen effluvium patients with healthy controls. Methods: Ninety-one patients diagnosed with telogen effluvium and 35 healthy volunteers were included in the study. Serum ischemia-modified albumin level was determined by a fast-colorimetric method, and albumin cobalt binding test. The results were evaluated statistically. Results: There was no statistically significant difference between the serum albumin values of patient and control groups (p = 0.739). Serum ischemia-modified albumin values were significantly higher in the patients with telogen effluvium than healthy controls (p < 0.001). Study limitations: Body mass index values of the patient and control groups could not be calculated. Conclusions: To the best of the authors' knowledge, this is the first clinical study to investigate the role of oxidative stress in the pathogenesis of telogen effluvium using ischemia-modified albumin as a biomarker. Based on the results of the present study, it can be considered that oxidative stress plays an important role in the pathogenesis of telogen effluvium. There is a need for further studies to support the results of this study, to demonstrate the possible effects of oxidative stress, and to investigate the other oxidative stress markers in the pathogenesis of telogen effluvium. (C) 2020 Sociedade Brasileira de Dermatologia. Published by Elsevier Espana, S.L.U.Öğe Review of family physician applications and referral status of patients with skin problems who applied to dermatology clinic: a survey study(Carbone Editore di Alessandro Pennino, 2019) Öztekin, Coşkun; Öztekin, AynureIntroduction: The aim of the present study is to evaluate the family physician applications, diagnosis and referral status of patients who admitted to dermatology clinic. Materials and Methods: Voluntary patients who were applied to dermatology clinic were included in the study. The 14-item questionnaire was administered by a dermatologist through face-to-face interview method after examination. Results: A total of 1009 patients completed the survey. Of these, 69.67% (n=703) were female and 30.33% (n=306) were male. The mean age of the study participants was 42.37±18.16 years. Most of the patients have applied with the same complaints to health caregivers (n=500, 49.55%) or family physicians (n=172, 17.04%) before dermatology clinic visit. Female participants more likely knew their family physicians compared to males (p=0.03). One hundred and thirty (%12.85) patients were treated previously by the family physician for the same complaint. Twenty-six of them referred to a dermatologist. Discussion: Patients receive less service from family physicians related to skin diseases. Most patients applied directly secondary and tertiary health care centers for skin problems.Öğe Rozasea hastalarında demodex spp'nin araştırılması(Hitit Üniversitesi, 2019) Koşar, Nezahat; Sabancılar, Emine; Karasartova, Djursun; Güreser, Ayşe Semra; Öztekin, Aynure; Derici, M. Kürşat; Gazi, Umut; Artüz, Refika Ferda; Taylan Özkan, Hikmet Ayşegülİnsizyonel herni gelişiminde risk faktörlerinin saptanması Amaç: Rozasea, yüz bölgesinde çeşitli klinik bulgularla seyreden, değişik alt tipleri olan ve sebebi tam olarak bilinmeyen kronik enflamatuvar bir cilt hastalığıdır. Demodex spp. rozasea etyolojisinde rol oynadığı düşünülen insan derisinin zorunlu paraziti olan bir akardır. Çalışmanın amacı rozasea tanılı kadın hastalarda demodeks saptanma sıklığını ve rozasea alt tipleri ile parazitin saptanma yoğunluğu arasındaki ilişkiyi saptamaktır. Gereç ve Yöntem: T.C. Sağlık Bakanlığı Hitit Üniversitesi Erol Olçok Eğitim ve Araştırma Hastanesi Deri ve Zührevi Hastalıklar polikliniklerine Şubat-Aralık 2017 tarihleri arasında rozasea nedeniyle başvuran 27-73 yaş arasındaki 39 kadın hasta çalışmaya dahil edilmiştir. Hastalardan burun, yanak ve çene derisinden ayrı ayrı olmak üzere birer adet toplamda üç adet örnek standart yüzeyel deri biyopsisi yöntemi ile alınarak ışık mikroskobunda incelenmiştir. Bulgular: Otuz dokuz hastanın 34 (%87,2)'ünde demodeks saptanmıştır. Hastaların 14 (%35,9)'üne eritematotelenjiektatik; 25 (%64,1)'ine papülopüstüler rozasea tanısı konulmuştur. Eritematotelenjiektatik hasta grubundakilerin 11 (%78,5)'inde, papülopüstüler hasta grubundakilerin 23 (%92)'inde demodeks saptanmıştır. İki grup arasında yapılan istatistiksel analizde demodeks yoğunluğu ile rozasea alt tipi arasında anlamlı bir ilişki bulunamamıştır (p=0,276). Sonuç: Rozasea hastalarında demodeks enfestasyonun yüksek oranlarda görülmesi nedeniyle tanıda araştırılması gerektiği akıldan çıkarılmamalıdır. Ayrıca rozasea alt tiplerinde parazitin etkisini ve hastalığın etiyopatogenezini daha iyi ortaya koymak için daha fazla sayıda hasta grubu ile ilave çalışmalar yapılması faydalı olacaktır.Öğe Skin-homing T-cell responses associated with Demodex infestation and rosacea(Wiley, 2019) Gazi, Umut; Güreser, Ayşe Semra; Öztekin, Aynure; Karasartova, Djursun; Koşar Acar, Nezahat; Derici, Mehmet Kürşat; Taylan Özkan, Hikmet AyşegülAims Our aim was to investigate the skin-homing T-cell immune responses triggered in patients with Demodex infestation and/or rosacea. Methods Collected whole blood samples were divided into four groups: control subjects; nonrosacea patients with Demodex infestation (Demodex group); papulopustular rosacea (PPR) patients without Demodex infestation (Rosacea group); and PPR patients with Demodex infestation (Rosacea/Demodex group). Following ex vivo activation, skin-homing CLA+CD4+ T-cell subset levels were monitored by flow cytometry. Results When compared with control subjects, among skin-homing CD4+ T-cell subsets analysed, Demodex patients had higher T(H)9 and T-reg cell levels; Rosacea subjects displayed elevated T(H)1 cell levels; and Rosacea/Demodex patients exhibited increased frequencies of T(H)9 and T(H)22 cells. In contrast to Rosacea subjects, Rosacea/Demodex group members displayed higher T(H)2 cell levels; and when compared with Demodex groups, they had higher T(H)1 and T(H)2 but lower T-reg cell levels. Demodex group members also exhibited higher T-reg but lower T(H)1 and T(H)22 levels than Rosacea/Demodex group subjects. Conclusions The skin-homing T-cell responses associated with Demodex infestation and rosacea formation seem to influence each other. The present as well as future studies could contribute to the development of effective treatment strategies for demodicosis and rosacea.Öğe Sleep Quality and Depression in Vitiligo Patients(2020) Öztekin, Aynure; Oztekin, CoskunAim: Vitiligo is a common disorder that has not only dermatological but also psychological consequences. The aim of this study was to compare depression and sleep quality of vitiligo patients with healthy control group. Methods: In this cross-sectional case-control study, patients admitted to the Dermatology Clinic of Skin and Venereal Diseases Department of Hitit University Erol Olçok Education and Research Hospitalbetween August 2018 and August 2019 were compared with healthy control group. The study included 67 patients and 69 control group participants who were matched for age, sex, marriage status, and education level. The subjects were asked to complete a sociodemographic data form, the Beck Depression Inventory, and the Pittsburgh Sleep Quality Index. Results: The median total Pittsburgh Sleep Quality Index score was higher in the patient group compared with the control group. The median scores for subjective sleep quality, sleep latency, and sleep disturbance were also higher in the patient group compared with the control group. A family history of vitiligo was present in 18 (26.9%) patients. The most common type was acrofacial vitiligo, which was present in 29 (43.3%) patients.Conclusions: Increased probability levels of depression and impaired sleep quality in vitiligo patients suggest that psychiatric evaluation and treatment should be provided for vitiligo patients as a part of a multidisciplinary approach in order to increase the success of the treatment.Öğe The association between verruca vulgaris and Vitamin D: Is there a casual link?(Carbone Editore di Alessandro Pennino, 2018) Öztekin, Coşkun; Öztekin, Aynure; Taştan, Kenan; Özmen, Gülsen Gül; Demir Pektaş, SuzanIntroduction: Verruca vulgaris is a well-known skin lesion caused by human papillomavirus. There are topical, local invasion and immune therapy options for verruca vulgaris. The role of Vitamin D levels in patients with verruca vulgaris is not clear. We investigated the serum Vitamin D levels in patients with verruca vulgaris. Materials and methods: Fifty-five patients with verruca vulgaris (Group I) and 60 healthy controls (Group II) included in the study. The characteristics of verruca vulgaris (duration, clinical type, the number of lesions, family history) and demographics of the participants were recorded. Serum 25-hydroxycholecalciferol levels were measured using electrochemiluminescence binding method. Results: After covariance analysis, we found no statistically significant difference between the groups in terms of mean age (23.38±4.68 years in Group I versus 27.35±8.14 years in Group II). Other baseline characteristics were not significantly different between the groups (p > 0.05 for all). The mean duration of verruca vulgaris was 12 (4-18) years and the most common sites were hand (26 patients, 47.3%) and foot (23 patients, 41.8%). Serum Vitamin D levels were 8.35±6.03 ng/ml in Group I and 18.08±10.01 ng/ml in Group II. There was a statistically significant difference between the groups in terms of serum Vitamin D levels (p < 0.001). Conclusion: In this study, Vitamin D levels in patients with verruca vulgaris were found to be decreased compared to healthy controls. Low Vitamin D levels may play an etiological role in the development of verruca vulgaris. © 2018 A. CARBONE Editore. All rights reserved.Öğe Thiol/disulfide homeostasis in patients with telogen effluvium: is oxidative stress important in the pathogenesis of telogen effluvium?(Wolters Kluwer ? Medknow, 2019) Savcı, Ünsal; Şahin, Mustafa; Şenel, Engin; Öztekin, Aynure; Muslu, Ümran; Sungur, Mustafa; Neşelioğlu, Salim; Erel, ÖzcanObjective: The aim of this study was to assess the correlation between telogen effluvium (TE) with the new oxidative stress (OS) indicator of thiol/disulfide balance and to research the role of OS in the pathogenesis of TE. Methods: Our study included 101 patients with TE diagnosis and 39 healthy individuals. Serum thiol/disulfide was measured with a new automated spectrometric method developed by Erel and Neselioglu, and results were compared statistically. Results: Among the six thiol/disulfide parameters, there were statistically significant differences for native thiol, total thiol, disulfide, disulfide/native thiol, disulfide/total thiol, and native thiol/total thiol studied in the patient and control groups (P = 0.042, 0.044, < 0.001, respectively). Conclusions: Based on the results of this study, it can be said that OS is closely associated with TE pathogenesis. There is a need for new studies that will show the possible effects of OS on TE pathogenesis and research different OS markers in addition to thiol/disulfide parameters.Öğe Vitamin D levels in patients with recurrent aphthous stomatitis(BMC, 2018-11-09) Öztekin, Aynure; Öztekin, CoşkunBackground Lower serum vitamin D levels, a major public health problem worldwide, has been found to be associated with various infectious diseases, cancers, autoimmune and dermatological diseases. The serum levels of vitamin D in patients with recurrent aphthous stomatitis are not clear. We investigated the vitamin D levels in patients with recurrent aphthous stomatitis. Methods Forty patients with recurrent aphthous stomatitis (Group I) and 70 healthy controls (Group II) included in the study. The characteristics of aphthous lesions (duration of disease and remission, frequency, diameter and number of the lesions) and demographics of the participants were recorded. Serum 25-hydroxycholecalciferol levels were measured using electrochemiluminescence binding method. Results There was no statistically significant difference between the groups in terms of age (p = 0.06) and sex (p = 0.4). Other baseline characteristics were not significantly different between the groups (p > 0.05 for all). The mean diameter of aphthous lesions was 0.5 (0.4–0.6) cm and the mean number of lesions was 2.2 ± 1.5. Serum vitamin D levels were 11 ± 7.04 ng/ml in Group I and 16.4 ± 10.19 ng/ml in Group II. Serum vitamin D levels were significantly lower in patients with recurrent aphthous stomatitis (p = 0.004). Conclusions The present study showed lower vitamin D levels in patients with recurrent aphthous stomatitis compared to healthy controls.
