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    Öğe
    Cognitive Impairment not only in NeuroBehcet but also for all Behcet Disease Phenotypes
    (2014) Karadağ Sücüllü, Yeşim; Kurt, Pınar; Şahin, Kubilay; Karaaslan, Yaşar; Öztekin, Neşe; Ak, Fikri
    Background: Cognitive impairment has been reported for Behçet's Disease (BD) patients, but studies are limited. This study is aimed to investigate neurocognitive profile of Neurobehcet Disease (NBD) patients and BD patients without neurologic involvement (BD-only) in comparison to healthy controls (HC). Patients and method: Totally 49 BD patients (11 NBD, 38 BD-only) and 32 HC were included into the study. After neurological evaluation, all subjects were given a comprehensive battery of neuropsychological tests: Self report of neuropsychological condition (by visual analogue scale-VAS, 0-100), RAVLT, Stroop, PASAT, TMT, SDMT, JLOT, DST, COWAT, ACTT, FST. Results: In the comparison of HC to NBD and BD-only subjects, a poorer performance was observed in both group of patients in almost all the neurocognitive tests, except for Stroop interference score. Both group of patients had lower scores on learning, immediate memory, working memory (ACTT), lexical fluency (COWAT) and attention (DST) comparing to healthy subjects (p≤0.003). The differences between NBD and BD-only patients were observed on response inhibition ability (STROOP-spontaneous corrections; p=0.000, and errors;p=0.002) and learning (RAVLT-sum of five trials; p=0.002). NBD patients had further decrease on free recall (RAVLT), complex visual processing (JLOT), information processing speed (PASAT), attention (TMT-B) and psychomotor speed (TMT-A) (p≤0.003). Conclusion: Cognitive functions of not only NBD patients but also BD-only patients were worse than control group. Compared to BD-only patients, NBD patients reveal further impairment on memory and executive functions rather than complex visual perception and verbal attention.
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    Öğe
    The association between the parenchymal neurological involvement and posterior uveitis in Behçet's syndrome
    (Clinical and Experimental Rheumatology S.A.S., 2016) Bitik, Berivan; Tufan, Abdurrahman; Şahin, Kubilay; Sucullu Karadağ, Yeşim; Can Sandıkçı, Sevinç; Mercan, Rıdvan; Ak, Fikri; Karaaslan, Yaşar; Öztürk, Mehmet Akif; Göker, Berna; Haznedaroğlu, Seminur
    Objective. Behçet's syndrome (BS) is a systemic vasculitis, which may involve multiple organ systems simultaneously. Clinical findings in BS often fit into well-recognised patterns, such as the association between papulo-pustular skin lesions and arthritis. We have recently observed a distinct pattern, in which a subtype of neuro-Behçet's syndrome (NBS) is often preceded by specific ophthalmic manifestations of the disease process. The purpose of this study is to evaluate the association between the parenchymal subtype of NBS and posterior uveitis (PU). Methods. We retrospectively reviewed the clinical records of 295 patients with BS, who met the international classification criteria for BS, diagnosed at two major rheumatology clinics from 2010 to 2014. Patient demographics, ophthalmic examinations, clinical and radiologic patterns of neurological involvement were recorded. Manifestations of BS were classified as PU, NBS, vascular involvement, and arthritis. The association between clinical findings was analysed for statistical significance. Results. Of the 295 patients, 100 had PU and 44 had NBS. 30 patients had parenchymal NBS and 14 had vascular NBS. Patients with PU were significantly more likely to have neurological involvement compared to those without PU (p < 0.001; odds ratio: 3.924; 95% CI: 1.786-8.621). Rate of posterior uveitis was higher in patients with parenchymal NBS when compared to patients with vascular NBS, vascular BS or arthritis (63.3%, 21.4%, 22% and 4.2% respectively, p < 0.001). Conclusion. Our findings suggest a clinically and statistically significant association between posterior uveitis and parenchymal type of neurologic involvement in BS. The development of posterior uveitis in a patient with previously diagnosed BS should be recognised as a "warning sign" for predisposition to neurologic involvement. These patients should be informed about the possible signs and symptoms of neurological involvement, which can cause very rapid and irreversible damage unless recognised and treated immediately. © Clinical and Experimental Rheumatology 2016.