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  • Küçük Resim
    Öğe
    Evaluation of serum CXC chemokine ligand 16 (CXCL16) as a novel inflammatory bio-marker or familial Mediterranean fever disease
    (Tubitak Scientific & Technical Research Council Turkey, 2021) Akyol, Taner; Düzenli, Tolga; Tanoğlu, Alpaslan
    Background/aim: Familial Mediterranean fever (FMF) is a disease that is mainly diagnosed with clinical features. Several wellknown inflammatory markers increase in FMF. However, there is still a need for diagnostic tests for specifying FMF and monitoring inflammatory activity. CXCL16 is a chemokine produced by inflammatory cells that demonstrate efficacy in the acute phase response. In this study, we aimed to investigate the relationship between CXCL16 levels and FMF disease and to evaluate CXCL16 levels as a novel biomarker for FMF. Materials and methods: Fifty-three male patients diagnosed with FMF and sixty healthy individuals were included in this crosssectional study. Blood samples were taken in the first 24 h of the attack periods. Serum soluble CXCL16 was evaluated by enzyme-linked immunosorbent assay (ELISA) method. Results: CXCL16 (P < 0.001), erythrocyte sedimentation rate (P < 0.001), C-reactive protein (P < 0.001), and fibrinogen (P = 0.005) were significantly higher in FMF group than in control group. Receiver operating characteristic (ROC) curve analysis revealed a cut off value of CXCL16 as 2.68 ng/ml with 83% sensitivity and 68% specificity (P < 0.001). Logistic regression analysis indicated that high CXCL16 and erythrocyte sedimentation rate levels were predictive parameters for FMF disease (OR 8.31; 95% CI 2.59-26.62; p <0.001) (OR 1.27; 95% CI 1.12-1.44; P < 0.001). There was no correlation between CXCL16 levels and attack frequency and disease duration (P = 0.395, P = 0.956). Conclusion: To the best of our knowledge, this is the first study evaluating serum soluble CXCL16 levels as a biomarker for FMF. CXCL16 levels were significantly higher and were predictive for monitoring inflammatory activity in patients with FMF. CXCL16 may be a promising biomarker for FMF diagnosis.
  • Küçük Resim
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    Gilbert Sendromunun Hematolojik Parametreler üzerine etkisi var mı?
    (Gazi Üniversitesi, 2020) Düzenli, Tolga; Çakır Güney, Başak; Tanoğlu, Alpaslan; Kaplan, Mustafa; Akyol, Taner
    Amaç: Gilbert sendromu, artmış indirek bilirubin düzeyleri ile karakterize, tekrarlayan hafif sarılıklarla seyreden benign bir hastalıktır. Bu çalışmanın amacı, bilirubinin artmış seviyelerinin, kırmızı küre dağılım genişliği (RDW), ortalama trombosit hacmi (MPV), nötrofil/lenfosit oranı (NLR), platelet/lenfosit oranı (PLR) ve diğer hematolojik parametreler üzerindeki etkilerini araştırmaktır. Yöntem: İşe giriş muayeneleri için başvuran 20-28 yaş arası toplam 1190 genç erkek birey çalışmaya alındı. İşe giriş muayeneleri kapsamında ayrıntılı anamnez alımı, detaylı fizik muayene, hematolojik ve biyokimyasal parametreleri, tüm abdominal ultrasonografileri yapıldı. Kriterleri karşılayan 774 hasta arasından indirekt bilirubin yüksekliği dışında patolojik neticesi olmayan 63 hastaya Gilbert sendromu tanısı kondu. Kontrol grubu olarak 70 hasta rastgele olarak 711 hasta arasından seçildi. İstatistiksel olarak karşılaştırma ve korelasyon analizleri yapıldı. Bulgular: Gilbert sendromu grubunda RDW 12,0 ± 1,1; MPV 7,7 ± 0,7 fl; NLR 2,23±1,07; PLR 113,1±31,0 idi. Kontrol grubunun ise RDW değeri 11,8 ± 0,9 (p=0,153); MPV 8,2 ± 0,8 fl (p
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    Öğe
    NLR and PLR as novel prognostic biomarkers of mucosal healing in ulcerative colitis patients treated with anti-TNF
    (Oxford University Press, 2020) Düzenli, Tolga; Köseoğlu, Hüseyin; Akyol, Taner
    To the Editors, We read with curiosity the recently published article titled “Novel Prognostic Biomarkers of Mucosal Healing in Ulcerative Colitis Patients Treated with Anti-TNF: Neutrophil to Lymphocyte Ratio and Platelet-toLymphocyte Ratio” by Bertani et al.1 In the article, authors aimed to assess whether neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) could be used as prognostic markers of antitumor necrosis factor (anti-TNF) treatment response in patients with ulcerative colitis.