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    Co-occurence of follicular lymphoma and Langerhans cell histiocytosis with primary parotid gland involvement: a case report
    (Elsevier Editora Ltda, 2021) Albayrak, Aynur; Yıldız, Abdulkerim; Albayrak, Murat; Uçaryılmaz Özhamam, Esra; Maral, Senem
    Follicular lymphoma (FL) is one of the most common types ofNon-Hodgkin Lymphoma (NHL) which originates from B-cells.1Generally it has an indolent clinical course, althoughhistological transformation to aggressive lymphoma mayoccur in 25-35 % of cases, and therafter the prognosis hasbeen reported to be poor. Transformation to histiocytic sar-coma may also be seen but very rarely
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    Öğe
    The effects of sildenafil and tadalafil on ischemia-reperfusion injury in rat ovarian torsion model
    (S.O.G. CANADA Inc., 2017) Toğrul, Cihan; Çitil Doğan, Ayşe; Başer, Eralp; Doğan, Murat; Albayrak, Aynur; Çağlar, Mete; Güngör, Tayfun; Öztürk, Gülfen; Fadıllıoğlu, Ersin; Delibaşı, Tuncay
    Objective: In cases of ovarian torsion (OT), reperfusion injury may further damage ovarian tissue. Tadalafil and sildenafil are phosphodiesterase- 5 (PDE-5) inhibitors that are primarily used for treatment of erectile dysfunction and pulmonary hypertension. In this study, the authors investigated the effects of these agents in preventing ovarian ischemia-reperfusion injury in a rat OT model. Materials and Methods: A total of 48 young adult female Wistar Albino rats were randomized into six groups (n=8 in each group); group 1: controlsham operated, group 2: sildenafil one mg/kg, group 3: tadalafil one mg/kg, group 4: sildenafil one mg/kg + ischemia/reperfusion, (I/R) two hours of ischemia and two hours of reperfusion and a single dose of oral one mg/kg sildenafil one hour before I/R, group 5: I/R, and group 6: tadalafil one mg/kg + I/R two hours of ischemia and two hours of reperfusion and a single dose of oral one mg/kg tadalafil one hour before I/R. Histopathologic evaluation was performed and scored according to the degree of congestion, edema, and hemorrhage. Total histological score (THS), tissue protein carbonyl (PC), malondialdehyde (MDA) levels, and catalase (CAT) activity were also calculated. Results: Group 4, group 5, and group 6 had similar congestion, edema and THS (p > 0.05). Group 6 had significantly lower hemorrhage score, when compared with group 5 (p = 0.03). Mean PC, MDA levels, and CAT were similar between groups 4, 5, and 6 (p > 0.05). Conclusions: Tadalafil was associated with a decreased tissue hemorrhage score in I/R injury in rat ovarian torsion model.