Yazar "Altay, Mustafa" seçeneğine göre listele

Listeleniyor 1 - 3 / 3
  • Küçük Resim
    Öğe
    Is thyroid function associated with masked hypertension?
    (Turkish Society of Cardiology, 2016) Ateş, İhsan; Altay, Mustafa; Kaplan, Mustafa; Arıkan, Mehmet Fettah; Özkayar, Nihal; Alagüney, Mehmet Erdem; Dede, Fatih; Özkara, Adem
    Masked hypertension (MHT) was first defined by Pickering in 1992, and its importance is progressively increasing (1). MHT is a condition wherein blood pressure measured according to hypertension guidelines in office is normal, whereas the mean 24-h ambulatory blood pressure measurement or blood pressure measurement out of office is high (2). Studies relating to the etiology of MHT is limited, and possible etiological factors include work stress, smoking, alcohol use, male sex, and excessive physical activity (3, 4). The association between MHT and thyroid hormone, which has major effects on the cardiovascular system, is not known. This study aims to investigate the association between thyroid hormone and blood pressure in newly diagnosed MHT patients
  • Küçük Resim
    Öğe
    Relationship between socioeconomic level, and the prevalence of masked hypertension and asymptomatic organ damage
    (International Scientific Information, Inc., 2015) Ateş, İhsan; Altay, Mustafa; Kaplan, Mustafa; Özkayar, Nihal; Toprak, Güvenç; Alagüney, M. Erdem; Özkara, Adem
    Background: This study aimed to determine the prevalence of masked hypertension (MHT) and its association with asymptomatic organ damage (AOD) in a low socioeconomic district of Ankara, Turkey. Material/Methods: We retrospectively reviewed data obtained from the medical records of 712 patients with no known diagnosis of hypertension who presented to a polyclinic due to symptoms related to elevated blood pressure (BP) and were screened for MHT. Essential hypertension (EHT) existed in 86 patients screened for AOD. The presence of AOD in patients diagnosed with MHT and EHT was recorded. Results: Among the 712 patients, 206 were diagnosed with EHT. Among the remaining 506 patients, 73 were diagnosed with MHT. The patients with MHT had significantly higher left ventricular mass index, carotid intima-media thickness, and 24-h urinary microalbuminuria level (all indicators of AOD) than those with EHT. Conclusions: A significantly higher percentage of patients with MHT had AOD, as compared to those with EHT, in a low socioeconomic district of Ankara. Based on this finding, patients who present with hypertensive symptoms but have a normal BP should be advised to measure their BP at home. © Med Sci Monit, 2015.
  • [ X ]
    Öğe
    The impact of levothyroxine sodium treatment on oxidative stress in Hashimoto's thyroiditis
    (BioScientifica Ltd., 2016) Ateş, İhsan; Altay, Mustafa; Yılmaz, Fatma Meriç; Topçuoğlu, Canan; Yılmaz, Nisbet; Berker, Dilek; Güler, Serdar
    Objective: Although several studies reported increased oxidative stress in Hashimoto's thyroiditis (HT), the effect of levothyroxine treatment on oxidative status is not studied extensively. Therefore, we conducted this study to investigate the effects of levothyroxine replacement on oxidative stress in HT. Design and methods: Thirty-six patients recently diagnosed with HT-related hypothyroidism and 36 healthy controls were included in the study. Levothyroxine replacement was started to patients with hypothyroidism, and had been followed-up for 6 months. Results: Mean basal serum total antioxidant status (TAS), total thiol, arylesterase, and paraoxonase 1 (PON1) levels were significantly lower, and serum total oxidant status (TOS) and oxidative stress index (OSI) were significantly higher in the patients with hypothyroid than the controls. In the hypothyroid group serum TAS, total thiol, arylesterase, and PON1 levels increased and serum TOS and OSI levels decreased significantly after levothyroxine treatment. Pretreatment serum TAS, total thiol, PON1, and arylesterase levels were positively correlated with free levothyroxine (fT4) and negatively correlated with thyroid-stimulating hormone (TSH), antithyroid peroxidase (anti-TPO), and antithyroglobulin (anti-TG) levels. Also, pretreatment serum TOS and OSI levels were negatively correlated with fT4 levels and positively correlated with TSH, anti-TPO, and anti-TG. We have also found that the fT4 and anti-TPO levels are independent predictors of the oxidative stress parameters in stepwise multivariable linear regression analysis. Conclusion: This study suggests that levothyroxine replacement decreases oxidant status and increases antioxidant status following the 6 months of levothyroxine replacement in hypothyroidism that develops in accordance with the HT. © 2016 European Society of Endocrinology.