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    Antioxidant and Cytotoxic Activity Studies in Series of Higher Amino Acid Schiff Bases
    (2020) Özdemir, Özlem; Gürkan, Perihan; Şimay Demir, Yaprak Dilber; Ark, Mustafa
    In this work, the antioxidant activity of the higher amino acid Schiff bases, which were prepared as the monosodium salts (1a–3a) and the neutral forms (1b–3b) was determined by DPPH scavenging assay. In pure MeOH solution, the scavenging ability of Schiff bases 1a-3a were higher than 1b-3b, but lower than ascorbic acid. The activity followed the order 3 (a,b) > 2 (a,b) > 1 (a,b). On the other hand, Schiff bases 2a and 3a behaved as the most effective scavengers of the DPPH radical in methanol-water mixture (v:v, 1:3). And, they were found to be have lower SC50 values in this mixture compared to pure methanol. In vitro cytotoxicity of these Schiff bases was studied against human cervical cancer cells (HeLa), human breast adenocarcinoma cells (MCF-7), and human normal embryonic kidney cells (HEK293). For HeLa cell line, Schiff bases 1a-3a exhibited a litttle high activity than 1b, but very low activity than doxorubicin. Schiff bases 2b and 3b had no cytotoxicity against HeLa cell. For MCF-7 cell line, Schiff bases 1a, 3a, 1b and 3b nearly were inactive at 100 ?M, whereas 2a increased cell proliferation in the all tested concentration range. Differently, Schiff base 2b showed the highest cytotoxicity and killed 90 percent of MCF-7 cells at concentration of 100 ?M. For HEK-293, doxorubicin was strongly cytotoxic. Despite this, Schiff bases 1a, 3a and 3b were inactive, whereas the others showed little weak toxicity.
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    Öğe
    Novel palladium (II) complexes of N-(5-nitro-salicylidene)-Schiffbases: Synthesis, spectroscopic characterization and cytotoxicity investigation
    (Elsevier B.V., 2020) Özdemir, Özlem; Gürkan, Perihan; Ark, Mustafa; Şimay Demir, Yaprak Dilber
    A series of palladium(II) complexes (1ee3e) with the general formulae [Pd(L)(H2O)]$xH2O were newlysynthesized by the interaction of palladium(II) chloride and the monosodium salts ofN-(5-nitro-sali-cylidene)-Schiff base ligands (1ae3a) in aqueous DMF solution. The identities of all the complexes wereproven by elemental analysis, FTIR,1H,13CNMR,LCeMS, UVevis, XPS, powder XRD spectra, thermalanalysis, conductivity and magnetic susceptibility measurements. The obtained analytical and physico-chemical results exhibited a square-planar coordination of the palladium(II) ion having a doubledeprotonated ligand and a coordinated water molecule.In vitrocytotoxicity of these Pd(II) complexeswas screened against tumor cell lines (HeLa and MCF-7), and a normal human cell line (HEK-293). Thecomplexes 1e and 2e exhibited a moderate antitumor activity against HeLa cell lines, while 3e had betteractivity than standard anticancer drug, doxorubicin. All three complexes showed the best active cyto-toxicity than doxorubicin against MCF-7 cancer lines. For HEK-293 lines, a decrease in concentration ofthe complexes significantly decreased their toxicity.