Yazar "Arslan, Emine" seçeneğine göre listele
Listeleniyor 1 - 11 / 11
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe CERVICAL PATHOLOGIES RELATED TO DIFFERENT SUBTYPES OF HUMAN PAPILLOMAVIRUS AS ENVIRONMENTAL CONTAMINANT(Parlar Scientific Publications (P S P), 2020) Arslan, Emine; Yaman, Fikriye KaranfilHPV is one of the most common sexually transmitted diseases. Also, non-sexual transmission of the virus is often debated. It is also a major public health problem because of its strong association with cervical cancer and precursor lesions. HPV is an environmental carcinogen that has the strongest relationship with cancer. Virtually all cases of cervical cancer are attributable to HPV infection. The early detection of cervical HPV infection is thus very important for detecting cervical pathologies at the early stages in order to prevent the development of cervical cancer and to decrease the number of deaths caused by cervical cancer. The aim of our study is to evaluate the frequency of the occurrence of human papillomavirus (HPV) in patients with cervical precancerous pathologies and cervical cancer in Corum, a city in central Anatolia, to compare the frequency of the occurrence of HPV 16, 18, and other types in cervical intraepithelial neoplasia and malignancies and to evaluate the success of screening tests for detecting precursor lesions. This cross-sectional study was conducted in the Gynecology and Obstetrics Department of the Hitit University Research and Training Hospital in Corum Province. The study comprised 347 patients with cervical intraepithelial neoplasia or invasive cervical cancer. The frequency of occurrence of HPV and the HPV types was evaluated for each cervical pathology. HPV type 16 was detected in 122 patients (45% of the HPV DNA-positive group), HPV type 18 in 11 patients (4% of the HPV DNA-positive group), HPV types 16 and 18 in 8 patients (3% of the HPV DNA-positive group), HPV 16 in combination with types other than HPV 16 and 18 in 17 patients (6% of the HPV DNA-positive group), and at least one type other than HPV 16 and 18 in 115 patients (42% of the HPV DNA-positive group). At least one type of HPV was detected in 149 (88.2%) of the 169 patients who had a Pap smear result reported as no intraepithelial neoplasia or malignancy (normal, inflammation, or infection).Öğe Education Influence on Baby Naming(2018) Korkmazer, Engin; Arslan, Emine; Çift, TayfurObjective: The tradition of naming newborn babies shows differences between different societies and cultures. There are many factors that influence the naming trend, and the cultural evolution of the community can be followed by these names. In our study, we searched the effect of the education level on naming the newborn baby. Material and Methods: This is a prospective cross-sectional study. A total of 1372 pregnant women with low-risk pregnancies experiencing their first pregnancy were recruited for the study. The educational status, the name they planned to give to their baby to be born and the factors that influenced this were asked to these people by a questionnaire. Results: In our study, it was observed that as the level of education decreased, the tendency to give parental names increased, whereas on the contrary, as education level increased, there was a tendency to give a more unique name. Conclusion: As the level of education increases, the environmental interaction of the people increases and accordingly, alternative thoughts increase in naming and the tendency to give parental names decreases.Öğe Human Papilloma virüs enfeksiyonu farkındalığı açısından kimler hedef kitle olmalıdır? anket çalışması(Gunes Kitap Kirtasiye, 2015) Görkem, Ümit; Arslan, Emine; Toğrul, Cihan; Efetürk, Tünay; Güngör, TayfunAmaç: Servikal kanser dünyada görlen kadın kanserleri arasında üçüncü sıklıkta görülmektedir ve yeni olguların çoğu az gelişmiş bölgelerden bildirilmektedir. Sadece insidansı değil aynı zamanda Human Papilloma Virüs (HPV) enfeksiyonu ilişkili kansere bağlı mortalite de az gelişmiş ülkelerde daha yüksektir. Bu çalışmada servikal kanser ve HPV enfeksiyonu arasındaki bağlantıyla ilgili farkındalık düzeyinin araştırılması amaçlandı. Gereç ve Yöntem: Mart 2015- Temmuz 2015 tarihleri arasında Hitit Üniversitesi Eğitim ve Araştırma Hastanesi Kadın Hastalıkları ve Doğum Polikliniği’ne başvuran 451 kadından çalışma ile ilgili anketi doldurması istendi. Anket 2 bölümden oluşmaktaydı. İlk bölüm sosyal demografik özellikler ile ilgili, ikinci bölüm ise hastalık hakkında kişisel farkındalık durumu ile ilgiliydi. Bütün sorular daha doğru değerlendirme yapabilmek için kapalı uçlu (evet-hayır veya çoktan seçmeli) olarak hazırlandı. Bilinçli olarak cevaplandıramayacağı düşünülen hastalar çalışmaya dahil edilmedi. Bulgular: Ortalama yaş 31.82±9.53, 401 hasta (%88.9) evli, 33 hasta (%7.3) bekar, 17 hasta (%3.8) boşanmış/dul idi. Eğitim düzeyi 153 hastada (%33.9) ilkokul, 126 hastada ((%27.9) ortaokul, 96 hastada (%21.3) lise, 76 hastada (%16.9) üniversite idi. 97 hasta (%21.5) çalışıyor, 336 hasta (%74.5) ev hanımı, 18 hasta (%4.0) öğrenci idi. Çalışıyor olanlarda çalışmayanlara, yüksek eğitim seviyesi olanlarda ve şehirde yaşayanlarda kırsal alanda yaşayanlara yüksek farkındalık durumu arasında bağımsız bir ilişki saptandı. Sonuç: HPV kanser bağlantısı hakkında toplumsal eğitim girişimleri ve eğitim aktiviteleri kırsal alanda yaşayanları, işsiz kadınları ve düşük eğitim düzey grubunu hedeflemelidir.Öğe Is There a Relationship Between Vitamin D Deficiency Status and PCOS in Infertile Women?(Georg Thieme Verlag Kg, 2019) Arslan, Emine; Görkem, Ümit; Toğrul, CihanIntroduction It is still unclear in the literature whether low vitamin D levels play a role in the pathogenesis of polycystic ovary syndrome (PCOS), especially with respect to the regulation of anti-Mullerian hormone (AMH). Therefore, we aimed to investigate whether there could be a relationship between vitamin D deficiency status and PCOS. Materials and Methods A total of 146 infertile women were divided into two groups according to their ovarian reserve patterns: (i) normal (NOR), and (ii) high (PCOS). The participants were also categorized into two groups according to vitamin D concentrations: (i) Group A < 10 ng/mL, and (ii) Group B 10-20 ng/mL. Samples were obtained and analyzed for estradiol (E2), follicle-stimulating hormone (FSH), luteinizing hormone (LH), total testosterone (TT), 17-hydroxyprogesterone (17-OHP), dehydroepiandrosterone sulfate (DHEA-S) and AMH. Results In the NOR group, there were significant differences between Group A and Group B in terms of anthropometric characteristics (p < 0.05, for all). The women in both Group A and Group B had similar AMH concentrations (p > 0.005). Only the NOR group showed a significant though moderate negative correlation between 25(OH) D levels and anthropometric parameters. AMH levels were not correlated with 25(OH) D levels in the NOR or the PCOS group (r = -0.112, p = 0.008; r = 0.027, p = 0.836). Multivariate regression analysis showed no impact of 25(OH) D on other study parameters. Only AMH measurements were significant enough (p < 0.001) to differentiate between PCOS and NOR patterns. Conclusion We found no difference in serum 25(OH) D and AMH levels between women with and women without PCOS. No correlation could be demonstrated between 25(OH) D and AMH in the PCOS group or controls.Öğe Is there a role for kisspeptin in pathogenesis of polycystic ovary syndrome?(Taylor and Francis Ltd, 2018) Görkem, Ümit; Toğrul, Cihan; Arslan, Emine; Sargın Oruç, Ayla; Büyükkayacı Duman, NuriyeAim: To investigate association of kisspeptin levels in infertile women with different ovarian reserve patterns. Materials and methods: In this prospective cross-sectional study, 157 participants were recruited. The women were divided into three groups: (i) adequate ovarian reserve (AOR) (n = 57), (ii) high ovarian reserve (PCOS) (n = 60), (iii) diminished ovarian reserve (DOR) (n = 40). Weight, height, waist circumference (WC), hip circumference (HC), body mass index (BMI), waist/hip ratio (WHR) were measured. The blood samples were analyzed for estradiol (E2), follicle-stimulating hormone (FSH), luteinizing hormone (LH), total testosterone (TT), 17-hydroxy progesterone (17OHP), dehydroepiandrosterone sulfate (DHEAS), antimullerian hormone (AMH), kisspeptin measurements. Results: FSH concentration was higher and AMH concentration was lower in DOR group (p <.001, p <.001, respectively). The mean LH, TT and DHEAS levels were higher in PCOS group (p =.001, p <.00 and p =.003, respectively). The 17OHP level did not differ among the groups (p =.15). Women with PCOS possessed the highest kisspeptin level (p =.01). The kisspeptin level was negatively correlated with FSH level (r = ?0.18, p =.02) and positively correlated with TT and DHEAS levels (r = 0.17, p =.02 and r = 0.23, p =.003, respectively). Conclusions: Women with PCOS had increased serum kisspeptin levels. Kisspeptin concentrations were negatively correlated with serum FSH and positively correlated with serum TT and DHEAS levels. © 2017 Informa UK Limited, trading as Taylor & Francis Group.Öğe Is There An Association Between Kisspeptin Levels And Gestational Diabetes Mellitus?(2020) Arslan, Emine; Görkem, Ümit; Toğrul, CihanOBJECTIVE: To find out the relationship of maternal serum levels of kisspeptin with gestational diabetes mellitus status. STUDY DESIGN: A total of 158 pregnant women between 24 and 28 weeks of gestation were divided into two groups according to gestational diabetes mellitus status: (i) Pregnant women with gestational diabetes mellitus (gestational diabetes mellitus group, n=76) and (ii) Healthy pregnant women (control group, n=82). Maternal serum concentrations of kisspeptin, insulin, and homeostasis model assessment- insulin resistance were assessed. RESULTS: In both groups, there were no difference in terms of age and gestational age (p=0.058 and p=0.820, respectively). The median of body mass indices of both groups at 24 to 28 weeks of gestation were statistically similar (p=0.062). The serum concentrations of kisspeptin did not demonstrate significant differences between the gestational diabetes mellitus and control groups (p=0.28). There was a significant difference in terms of serum level of insulin and homeostasis model assessment-insulin resistance between the gestational diabetes mellitus and control groups (p<0.001). CONCLUSION: No differences were found in serum kisspeptin levels between pregnant women with GDM and healthy pregnant women. Further prospective studies will be essential to elucidate the contribution of kisspeptin to gestational diabetes mellitus.Öğe Relationship between elevated serum level of placental growth factor and status of gestational diabetes mellitus(Taylor and Francis Ltd, 2020) Görkem, Ümit; Toğrul, Cihan; Arslan, EmineObjective: As only limited and confusing evidence about serum placental growth factor (PlGF) level in gestational diabetes mellitus (GDM) exist in the known literature, the aim of this study was to evaluate the association of maternal serum PlGF level with GDM status. Methods: The pregnant women attending the Obstetrics Outpatient Unit of Hitit University Hospital were screened at 24 and 28?weeks of gestation for GDM according to the suggestions of the American College of Obstetricians and Gynecologists (ACOG). Concisely, all of the low-risk pregnant women were evaluated with a 50?g glucose challenge test (GCT). Women with serum glucose ?140?mg/dL at 1?h after GCT were subjected to a 100?g oral glucose tolerance test (OGTT). According to the criteria of Carpenter and Coustan, the GDM diagnosis was confirmed. Consequently, a total of 158 pregnant women eligible for inclusion criteria were categorized into two main groups; 76 of the GDM group, 82 of the control group. The demographic characteristic and biochemical parameters of the study population including age, body mass index (BMI), gestational age were recorded at the second trimester. The assays for glucose, insulin, and PlGF were carried out. Results: The mean maternal age of control and GDM groups were 27.9 and 30.5?years, respectively. The parameters such as age, BMI, and gestational age were statistically similar in both groups (p>.05, for all). As expected, serum insulin level and homeostasis model assessment-insulin resistance (HOMA-IR) value were significantly elevated in women with GDM (p<.001, for both). Moreover, maternal PlGF concentration was found to be higher in the GDM group compared to the control group (p=.029). Pearson’s correlation analysis of PlGF with other study parameters revealed that there was a negative moderate and significant correlation in only control group (r=??0.416, p<.05). However, this correlation was not detected in the GDM group (r?=?0.099, p>.05). None of the variables including maternal age, BMI, insulin, and HOMA-IR showed significant correlations in GDM and control groups. Conclusion: Our findings revealed that maternal serum PlGF level is increased in pregnant women complicated with GDM. Early identification of pregnant women who subsequently will pose GDM risk could improve the pregnancy outcomes.Öğe Relationship between intercellular adhesion molecule-1 and morbidly adherent placenta(De Gruyter, 2019) Korkmazer, Engin; Nizam, Rampia; Arslan, Emine; Akkurt, ÖzgürMorbidly adherent placenta (MAP) is a clinical condition the prevalance of which is steadily increasing. It is described as the invasion of the placenta into the uterine wall through the myometrium and beyond. Several studies have shown that intercellular adhesion molecule-1 (ICAM-1) increases the invasion capability of tumor cells and placental cells. In our study, we investigated the expression of ICAM-1 in MAP cases. This is a prospective case-control study. Eighty-nine patients who were diagnosed with MAP and 96 patients, without adherent placenta, as a control group were included in the study. ICAM-1 staining was examined by immuno-histochemical staining in placental samples. Of the 89 patients in the MAP group, 72 (80.8%) showed positive staining, while 26 (27%) did so in the control group. ICAM-1 positive staining in the MAP group was statistically significantly higher (P=0.03). This is the first study investigating the relationship between MAP and ICAM-1 in the literature. In our study, we showed that ICAM-1 expression increased in the MAP group. © 2019 Walter de Gruyter GmbH, Berlin/Boston.Öğe Relationship between vascular cell adhesion molecule-1 and morbidly adherent placenta(Elsevier Masson SAS, 2018) Korkmazer, Engin; Nizam, Rampia; Arslan, Emine; Akkurt, ÖzgürIntroduction: Morbidly adherent placenta is a clinical condition of which prevalance is steadily increasing. It is described as the invasion of the placenta into the uterine wall through the myometrium and beyond. Vascular cell adhesion molecule-1 is a calcium independent transmembrane glycoprotein. Several studies have shown that vascular cell adhesion molecule-1 increases invasion in tumor cells. In our study we investigated the expression of vascular cell adhesion molecule-1 which has been shown to increase invasion in various tumors in morbidly adherent placenta cases. Material and method: This is a prospective case–control study. Eighty-four patients who were diagnosed with morbidly adherent placenta and 96 patients without any risk factors as a control group were included in the study. Vascular cell adhesion molecule-1 staining was examined by immune-histochemical staining in placental samples. Results: The patients included in the study were similar in terms of demographic characteristics. Of the 84 patients in the morbidly adherent placenta group, 65 (74.7%) showed positive staining. This number was 39 (40.6%) in the control group. Staining in morbidly adherent placenta group was statistically significantly higher (p < 0.05). Discussion: The etiology of morbidly adherent placenta is still a clinically unknown condition. This study is the first study on this field in the literature. In our study, we showed that vascular cell adhesion molecule-1 expression increased in morbidly adherent placenta group. Although the entire pathogenesis is not explained this can be considered as a step for understanding this subject. © 2018 Elsevier Masson SASÖğe The Oxidative Stress At Lungs After Menopause And The Antioxidant Effects Of Vitamin D, Fish Oil And Exercise in An Experimental Rat Model(Parlar Scientific Publications (P S P), 2020) Arslan, Sertaç; Arslan, Emine; Güney, Güven; Özcan, Oğuzhan; Demir, Emre; Uyar Hazar, Hale; Demirci, BuketMenopause is the permanent cessation of ovarian follicular activity and the menstrual cycle. There is little physiologic and histologic data concerning the possible effects of menopause on respiratory tract and possible beneficial agents for respiratory tract against the effects of menopause. The rat lungs and trachea have been obtainedfrom young and old rats which were treated with either vitamin D (VitD; 1000IU/kg/week),Fish oil (FO; 0.8 mL/kg/week) or exercise (running 45 minutes/3 times/week) for 12 weeks after one week overiectomy (OVX) followup. Oxidative stress markers found increased at OVX and OVX+E groups. However, oxidative stress marker levels were lower at OVX+E group than OVX group. Vitamin D and fish oil also caused decreased oxidative stress at lung tissue compared to OVX group. OVX group had histological changes such as epithelial desquamation, peribronchial smooth muscle hypertrophy, peribronchial lymphoid follicles, Type 2 pneumocyte hyperplasia; however, none of them was found at exercise group. Ovariectomy caused respiratory system effects in rats. Menopause cause oxidative stress; however, exercise, vitamin D and fish oil have protective effects against oxidative stress at lungs at different quantities. Ovariectomy group has the greatest damage compared to other groups. Exercise is the best protective modality against the effects of menopause at respiratory system.Öğe Two-Year Results of Community-Based Screening Program for Human Papilloma Virus DNA in Çorum Province(2019) Güney, Güven; Arslan, Emine; Baş, Yılmaz; Turgal, EbruObjective: The Turkish Ministry of Health started a community-based screening program using Human Papilloma Virus (HPV) DNA in 2014. In our study, we aimed to investigate the results of this survey in Çorum province between the years of 2016-17 to determine the shortcomings and deficiencies in practice. Material and Method: All of the women between the ages of 30 and 65 years who had undergone High risk HPV DNA screening in Çorum province between 2016 and 2017 were included in the study. High risk HPV types were divided into three categories as type 16, 18 and others. The target group of patients to be screened were compared with the numbers reached in the survey. After colposcopic biopsy, the clinicopathological correlation of the patients who underwent colposcopic biopsy was determined via pathology reports. Results: HPV DNA was detected in 817 women (3.5%). HPV types 16, 18 and others were found to be positive in 216, 32 and 569 individuals, respectively. Cervical biopsy was performed with colposcopy in 212 (26%) women. As the result of colposcopy, LSIL and HSIL were detected in 63 and 56 patients, respectively. 34.5% of patients with the diagnosis of any kind of dysplasia received treatments. Conclusion: It was determined that 44% of HPV DNA-positive patients were not subjected to the appropriate processes according to the national guidelines. This shows that despite the screening, the desired therapeutic effect could not be achieved.
