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    Evaluation of Nasal Mucociliary Clearance in COVID-19 Patients
    (2021) Uğurlu, Burak Numan; Yerlikaya, Hüseyin Serdar; Aktar Uğurlu, Gülay; Aslan Felek, Sevim
    Objective: There is no information about the relationship between coronavirus disease-2019 (COVID-19) and nasal mucociliary clearance (NMC). To investigate whether the severe acute respiratory syndrome-CoV-2 has an effect on NMC. Material and Methods: Thirty-two patients hospitalized in our hospital with the diagnosis of COVID-19 and confirmed by rt-PCR test were included in the study. Smokers and patients with chronic upper respiratory tract infection were excluded from the study. The saccharin test was performed to evaluate NMC. Patients over 50 and under 50 years of age were examined in two groups as the reference values change with age. Patients with and without pulmonary symptoms were compared in terms of NMC. In addition, patients with and without cough were compared in terms of NMC in their age groups. Results: The study included a total of 32 patients, 18 (56%) males and 14 (44%) females, with a mean age of 50.8 years (range, 17-81 years). The mean clearance time of the patients over 50 years of age (n=15) was 14.20±4.80 min, while under 50 years of age (n=17) was 11.94±3.61 min. When compared with the reference values in the literature, no significant difference was observed in both age groups (p>0.05). There was no significant difference in the patients over 50 years of age compared to the patients with lung involvement (n=11, mean=14.64, SD=5.26) and without lung involvement (n=4, mean=13, SD=3.56) (p>0.05). There was no significant difference in the patients under 50 years of age compared to the patients with lung involvement (n=7, mean=12.86, SD=4.78) and without lung involvement (n=10, mean=11.3, SD=2.63) (p>0.05). When the patients with and without cough complaint were compared between their age groups, no significant difference was observed (p>0.05). Conclusion: NMC has been preserved in COVID-19 patients. There is no significant difference in terms of lung involvement and cough complaints in NMC times.
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    Öğe
    Quantitative evaluation and progress of olfactory dysfunction in COVID-19
    (Springer, 2021) Uğurlu, Burak Numan; Akdoğan, Özlem; Arı Yılmaz, Yasemin; Yapar, Derya; Aktar Uğurlu, Gülay; Yerlikaya, Hüseyin Serdar; Aslan Felek, Sevim
    Purpose Since many different rates have been reported in the literature and the studies conducted are mostly based on the patient anamnesis, it was aimed to analyze the olfactory dysfunction in Coronavirus Disease 2019 (COVID-19) quantitatively and to reveal its progress by time. Methods Patients who described new-onset olfactory dysfunction, who were treated in the COVID-19 departments of our hospital and whose PCR tests demonstrated SARS-CoV-2 presence were included in the study and they were investigated prospectively. Clinical information of all the patients was taken and the levels of olfactory function were detected using the Brief Smell Identification Test (BSIT). Scores equal to or below 8 are considered as olfactory dysfunction. Patients who were followed up for 3 months were reevaluated with the BSIT test at the end of the third month and the progression of the symptom was investigated. Results The mean BSIT test score of the 42 patients (23 female patients, 19 male patients, mean age: 41.2 +/- 14.6) was 5.2 +/- 2.2. There was severe olfactory dysfunction in 16.7% of the patients (0-2 points), moderate olfactory dysfunction in 31% (3-5 points), and mild olfactory dysfunction in 52.4% (6-8 points). After a follow-up for 3 months, full recovery was observed in 36 patients (85.7%) and the mean test score rose to 9.9 +/- 1.8. Although olfactory dysfunction persisted in 6 patients, an elevation in test scores was noted. Olfactory dysfunction was the first symptom in 17 patients (40%) and the other symptoms occurred after 2 days (1-6) on average. Conclusion We investigated olfactory dysfunction caused by COVID-19 using BSIT, and found a high rate of moderate-mild level symptoms with a high level of recovery in the 3-month follow-up. The finding revealing that olfactory dysfunction was the first symptom in 40% of the patients suggests the importance of inquiry on olfactory functions for the early diagnosis of the disease.
  • Küçük Resim
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    The Importance of Imaging and Fine Needle Aspiration Biopsy in Primary Benign Parapharyngeal Space Tumors
    (2021) Aslan Felek, Sevim; Kaptan, Zeynep; Uğurlu, Burak Numan; Yiğit, Hasan; Ünverdi, Hatice; Demirci, Münir
    Objective: The purpose of this study is the comparison of the radiological pre-diagnosis with the cytopathological results acquired from fine needle aspiration biopsy (FNAB) and the post-operative final histopathological results in operated patients diagnosed to have primary benign parapharyngeal space (PPS) tumors. Material and Methods: In our study, 20 patients who were considered to be benign with preoperative imaging and FNAB between 2011 and 2017 were observed retrospectively. Patients suspected of malignancy with preoperative imaging or FNAB were excluded from the study. Results: From a total of 20 patients, 11 were female while 9 were male, and the mean age was 54 (21-78). In post-styloid region (n=10), the pre-operative radiological diagnosis was reported as paraganglioma (n=6), and peripheral nerve sheath tumors (n=4). In pre-styloid region (n=10), the preoperative radiological diagnosis was reported as deep lobe parotid tumor (warthin and pleomorphic adenoma) (n=6), lymphadenitis (n=1), minor salivary gland cyst (n=1), lipoma (n=1) and branchial cleft cyst (n=1). Compared to specimen results, preoperative imaging results of 20 patients were consistent with specimen in 18 patients, while specimen results were reported as malignant in 2 patients, although imaging was benign. FNAB was performed in 13 patients without vascular tumor suspicion, and results consistent with specimen results were obtained in 11 patients. Although FNAB results were reported as benign in 2 patients, the specimen result was reported as malignant. Conclusion: In our study, we found that, even if imaging and FNAB in PPS benign masses reported largely accurate results, it is rarely not able to rule out malignancy. These possibilities should be kept in mind when approaching the benign tumors of the parapharyngeal region.