Yazar "Azap, A" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • [ X ]
    Öğe
    A Systematic Review and Analysis of Brucella Endocarditis Cases
    (KARE PUBL, 2025) Başaran, S; Şimşek-Yavuz, S; Sarıcaoğlu, ME; Aydın, M; Aygün, G; Azap, A; Azap, Ö; Benli, A; Demirtürk, N; Ergönül, Ö; Kocagül-Çelikbağ, A; Kuşçu, F; Özger, S; Kutlu, SS; Türker, N; Türkoğlu-Yılmaz, E
    Endocarditis is the most common cause of death from brucellosis. The information used to guide the management of cases with Brucella endocarditis has relied on case reports/ series. Risk factors related to death and other adverse outcomes in patients with Brucella endocarditis were identified by an individual-patient data analysis of all reported Brucella endocarditis cases in the literature. The keywords Bruce and endocard were used to search articles published until July 2022 on PubMed and ULAKBIM databases. Case reports/series containing patients with endocarditis caused by Brucella spp., aged >= 17 years, and with data on antimicrobial or surgical treatment were included in the study. Epidemiological, clinical, laboratory, and treatment characteristics and outcomes of 273 cases from 86 eligible articles were recorded. It was found that male gender, a Wright serum tube agglutination (STA) titer of >= 1/1280 on admission, development of heart failure due to endocarditis were independent risk factors that increase mortality, while the usage of aminoglycoside and cardiac surgical intervention for endocarditis were factors reducing mortality. Including streptomycin or gentamicin in the treatment regimen may benefit patients with Brucella endocarditis. Valve surgery could be life-saving in patients with Brucella endocarditis. An STA titer of >= 1/1280, which probably reflects long-term and advanced disease, may be used as a marker for increased mortality. However, additional and more reliable studies are needed to define the most appropriate management approach in diagnosing and treating cases with Brucella endocarditis due to the low quality of the current evidence.
  • [ X ]
    Öğe
    Impact of the COVID-19 pandemic on surgical site infections: a multi-center study evaluating incidence, pathogen distribution, and antimicrobial resistance patterns
    (BMC, 2025) Keske, S; Altınok, ES; Azak, E; Gülten, E; Gülen, TA; Hatipoğlu, ÇA; Asan, A; Korkmaz, D; Kaçmaz, B; Kızmaz, Y; Batırel, A; Akgül, F; Yapar, D; Karakoç, ZÇ; Özel, AS; Yalçın, TY; Özer, D; Korkmaz, OE; Şahin, A; Karasin, MF; Turunç, T; Aydın, M; Demirtürk, N; Azap, A; Ergönül, Ö
    BackgroundSurgical site infections (SSIs) are among the most significant concerns in healthcare settings, presenting challenges in patient management and healthcare outcomes. The emergence of the COVID-19 pandemic has further complicated the landscape of infectious disease epidemiology, impacting the distribution and resistance characteristics of pathogens responsible for SSIs. Understanding these dynamics is essential for improving infection prevention and treatment strategies.MethodsThis retrospective multi-center study included 17 hospitals in Turkey, analyzing SSI cases from January 2019 to January 2023. The study was divided into three phases: pre-pandemic (January 2019 - March 2020), early pandemic (March 2020 - January 2022), and late pandemic (January 2022 - January 2023). We assessed demographic and clinical characteristics, pathogen distributions, and resistance rates, focusing on multidrug-resistant (MDR) pathogens.ResultsA total of 2,058 patients with SSIs were included. The SSI rate increased from 0.79% in 2019 to 0.87% in 2020, then decreased to 0.46% in 2021 and 0.50% in 2022. The most prevalent pathogens were E. coli (21.9%) and K. pneumoniae (14.6%). Resistance to meropenem in K. pneumoniae rose from 23% pre-pandemic to 33% post-pandemic, while ceftazidime-avibactam resistance surged from 6 to 43%. P. aeruginosa showed increased quinolone resistance from 18 to 27%, with colistin resistance rising to 13% in the late pandemic phase.ConclusionsThis study highlights the significant impact of the COVID-19 pandemic on SSIs in Turkey, revealing concerning trends in antibiotic resistance among key pathogens. Ongoing surveillance and enhanced infection control measures are essential to address these challenges and improve patient outcomes in the post-pandemic era.